Search Results - "Pernold, Karin"

Major oscillations in spontaneous home-cage activity in C57BL/6 mice housed under constant conditions by Pernold, Karin, Rullman, Eric, Ulfhake, Brun

“…The mouse is the most important mammalian model in life science research and the behavior of the mouse is a key read-out of experimental interventions and…”
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Bouts of rest and physical activity in C57BL/6J mice by Pernold, Karin, Rullman, Eric, Ulfhake, Brun

“…The objective was to exploit the raw data output from a scalable home cage (type IIL IVC) monitoring (HCM) system (DVC®), to characterize pattern of…”
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Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique by Pernold, Karin, Iannello, F, Low, B E, Rigamonti, M, Rosati, G, Scavizzi, F, Wang, J, Raspa, M, Wiles, M V, Ulfhake, B

“…Automated recording of laboratory animal's home cage behavior is receiving increasing attention since such non-intruding surveillance will aid in the unbiased…”
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Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice by Talamonti, Emanuela, Sasso, Valeria, To, Hoi, Haslam, Richard P., Napier, Johnathan A., Ulfhake, Brun, Pernold, Karin, Asadi, Abolfazl, Hessa, Tara, Jacobsson, Anders, Chiurchiù, Valerio, Viscomi, Maria Teresa

“…Docosahexaenoic acid (DHA) is a ω‐3 fatty acid typically obtained from the diet or endogenously synthesized through the action of elongases (ELOVLs) and…”
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High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio by Ross, Jaime M., Öberg, Johanna, Brené, Stefan, Coppotelli, Giuseppe, Terzioglu, Mügen, Pernold, Karin, Goiny, Michel, Sitnikov, Rouslan, Kehr, Jan, Trifunovic, Aleksandra, Larsson, Nils-Göran, Hoffer, Barry J., Olson, Lars, Bloom, Floyd

“…At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the…”
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Longitudinal Study of Changes in Ammonia, Carbon Dioxide, Humidity and Temperature in Individually Ventilated Cages Housing Female and Male C57BL/6N Mice during Consecutive Cycles of Weekly and Bi-Weekly Cage Changes by Andersson, Martina, Pernold, Karin, Lilja, Niklas, Frias-Beneyto, Rafael, Ulfhake, Brun

“…Housing conditions are essential for ensuring animal welfare and high-quality research outcomes. In this study, we continuously monitored air…”
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Adh1 and Adh1/ 4 knockout mice as possible rodent models for presymptomatic Parkinson's disease by Anvret, Anna, Ran, Caroline, Westerlund, Marie, Gellhaar, Sandra, Lindqvist, Eva, Pernold, Karin, Lundströmer, Karin, Duester, Gregg, Felder, Michael R., Galter, Dagmar, Belin, Andrea Carmine

“…► Adh1−/− and Adh1/ 4−/− mice have higher spontaneous activity compared to WT mice. ► Apomorphine increase locomotor activity in Adh1−/− and Adh1/ 4−/− mice. ►…”
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Glial cell line-derived neurotrophic factor partially ameliorates motor symptoms without slowing neurodegeneration in mice with respiratory chain-deficient dopamine neurons by Sterky, Fredrik H, Pernold, Karin, Harvey, Brandon K, Lindqvist, Eva, Hoffer, Barry J, Olson, Lars

“…Degeneration of midbrain dopamine neurons causes the striatal dopamine deficiency responsible for the hallmark motor symptoms of Parkinson's disease (PD)…”
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Home-Cage Monitoring of Activity Patterns of Laboratory Mice by Pernold, Karin

“…The mouse, deriving from the house mouse, is the most common species used in biomedical research, and offers great advantages for researchers to study gene…”
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Home-Cage Monitoring of Mouse Behaviours Across Life-Span by Pernold, Karin

“…Background and aimThe academic research involving animal testing is struggling with problems of reproducibility and a few of the specific reasons pointed out…”
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Inhibiting Epidermal Growth Factor Receptor Improves Structural, Locomotor, Sensory, and Bladder Recovery from Experimental Spinal Cord Injury by Erschbamer, Matthias, Pernold, Karin, Olson, Lars

“…Lack of axon regeneration in the adult CNS has been attributed partly to myelin inhibitors and the properties of astrocytes. After spinal cord injury,…”
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Comments on the re-assessment study by Sharp et al. of Erschbamer et al. : NIH REPLICATION STUDIES by ERSCHBAMER, Matthias, PERNOLD, Karin, OLSON, Lars

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Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury by Abrams, M Birdsall, Dominguez, Cecilia, Pernold, Karin, Reger, Roxanne, Wiesenfeld-Hallin, Zsuzsanna, Olson, Lars, Prockop, Darwin

“…Previous reports established that after a contusion injury to the rat spinal cord, locomotor function was enhanced by the transplantation of cells from bone…”
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Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior by Baek, Jean-Ha, Schmidt, Eva, Viceconte, Nikenza, Strandgren, Charlotte, Pernold, Karin, Richard, Thibaud J C, Van Leeuwen, Fred W, Dantuma, Nico P, Damberg, Peter, Hultenby, Kjell, Ulfhake, Brun, Mugnaini, Enrico, Rozell, Björn, Eriksson, Maria

“…Hutchinson-Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with multiple features suggestive of premature accelerated aging. Accumulation of…”
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Comments on the re-assessment study by Sharp et al. of Erschbamer et al by Erschbamer, Matthias, Pernold, Karin, Olson, Lars

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Lrrk2 and α-synuclein are co-regulated in rodent striatum by Westerlund, Marie, Ran, Caroline, Borgkvist, Anders, Sterky, Fredrik H., Lindqvist, Eva, Lundströmer, Karin, Pernold, Karin, Brené, Stefan, Kallunki, Pekka, Fisone, Gilberto, Olson, Lars, Galter, Dagmar

“…LRRK2, α-synuclein, UCH-L1 and DJ-1 are implicated in the etiology of Parkinson's disease. We show for the first time that increase in striatal α-synuclein…”
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Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease by Belin, Andrea Carmine, Björk, Behnosh F., Westerlund, Marie, Galter, Dagmar, Sydow, Olof, Lind, Charlotta, Pernold, Karin, Rosvall, Lina, Håkansson, Anna, Winblad, Bengt, Nissbrandt, Hans, Graff, Caroline, Olson, Lars

“…Mitochondrial (mt) dysfunction has been implicated in Alzheimer's (AD) and Parkinson's disease (PD). Mitochondrial transcription factor A (TFAM) is needed for…”
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Modeling Parkinson's disease genetics: Altered function of the dopamine system in Adh4 knockout mice by Belin, Andrea Carmine, Westerlund, Marie, Anvret, Anna, Lindqvist, Eva, Pernold, Karin, Ögren, Sven Ove, Duester, Gregg, Galter, Dagmar

“…▶d-Amphetamine induces increase in horizontal activity in Adh4−/− compared to Adh4+/+. ▶ Apomorphine induces increase in horizontal activity in Adh4−/−…”
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Recovery from spinal cord injury in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 null mice by Fraidakis, Matthew J, Kiyotani, Tetsuya, Pernold, Karin, Bergström, Jakob, Olson, Lars

“…Tumor necrosis factor-α is a central cytokine involved in the regulation of the innate immune response. Signal transducers and activators of transcription 4…”
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