Search Results - "Pernis, A."

Th17 cells in rheumatoid arthritis and systemic lupus erythematosus by Pernis, A. B.

“… Recent work has implicated a novel Th effector cell subset, the Th17 cell subset, in the development of both rheumatoid arthritis (RA) and systemic lupus…”
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Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice by Stirzaker, RA, Biswas, PS, Gupta, S, Song, L, Bhagat, G, Pernis, AB

“…Accumulating evidence from murine studies suggests that the RhoA/ROCK pathway plays an important role in the development of autoimmune disorders. We previously…”
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P076 Abnormal rock activity in CD4+ T cells upregulates IL-21 production and promotes type 1 diabetes in NOD mice by Biswas, P., Gupta, S., Chang, E., Bhagat, G., Pernis, A.

“…Aberrant production of IL-21 by CD4+ T cells play important role in the development of type 1 diabetes (T1D) in NOD mice. The pathogenic effects of IL-21 are…”
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Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4 by Gupta, S, Jiang, M, Anthony, A, Pernis, A B

“…Interleukin (IL)-4 is an immunoregulatory cytokine that exerts distinct biological activities on different cell types. Our studies indicate that interferon…”
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STF‐IL‐4: a novel IL‐4‐induced signal transducing factor by Schindler, C., Kashleva, H., Pernis, A., Pine, R., Rothman, P.

“…The mechanism by which interleukin‐4 (IL‐4) regulates the expression of particular genes is unknown. We have determined that IL‐4 induces a DNA binding factor…”
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IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells by Gupta, S, Jiang, M, Pernis, A B

“…IFN-alpha consists of a family of highly homologous proteins, which exert pleiotropic effects on a wide variety of cell types. The biologic activities of…”
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Stage-Specific Modulation of IFN-Regulatory Factor 4 Function by Kruppel-Type Zinc Finger Proteins by Gupta, Sanjay, Anthony, Alissa, Pernis, Alessandra B

“…Optimal humoral responses depend on the activation of Ag-specific B cells, followed by their progression toward a fully differentiated phenotype. Acquisition…”
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Intravenous pulse cyclophosphamide treatment of severe lupus nephritis: a prospective five-year study by Valeri, A, Radhakrishnan, J, Estes, D, D'Agati, V, Kopelman, R, Pernis, A, Flis, R, Pirani, C, Appel, G B

“…Despite its widespread use, there are only a few published studies of the use of intravenous high dose pulse cyclophosphamide in systemic lupus nephritis…”
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A Signaling Pathway Mediating Downregulation of BCL6 in Germinal Center B Cells Is Blocked by BCL6 Gene Alterations in B Cell Lymphoma by Saito, Masumichi, Gao, Jie, Basso, Katia, Kitagawa, Yukiko, Smith, Paula M., Bhagat, Govind, Pernis, Alessandra, Pasqualucci, Laura, Dalla-Favera, Riccardo

“…The BCL6 proto-oncogene encodes a transcriptional repressor necessary for the development of germinal centers (GCs) and directly implicated in lymphomagenesis…”
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Response to Ye Dong‐Qing by Pernis, A. B.

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Interleukin 4 Signals Through Two Related Pathways by Pernis, Alessandra, Witthuhn, Bruce, Keegan, Achsah D., Nelms, Keats, Garfein, Evan, Ihle, James N., Paul, William E., Pierce, Jacalyn H., Rothman, Paul

“…The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4)…”
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Increased rho kinase activity in temporal artery biopsies from patients with giant cell arteritis by Lally, Lindsay, Pernis, Alessandra, Narula, Navneet, Huang, Wei-Ti, Spiera, Robert

“…Aberrant rho kinase (ROCK) activity is implicated in the pathogenesis of several vascular diseases and is associated with Th17 differentiation. Th17 immune…”
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P12. Increased rho kinase (ROCK) activity in temporal arterial biopsies from patients with giant cell arteritis by Lally, L., Narula, N., Pernis, A. B., Huang, W.-T., Udeh, U., Spiera, R. F.

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Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression by Pauleau, Anne-Laure, Rutschman, Robert, Lang, Roland, Pernis, Alessandra, Watowich, Stephanie S, Murray, Peter J

“…Arginase I expression in the liver must remain constant throughout life to eliminate excess nitrogen via the urea cycle. In contrast, arginase I expression in…”
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Signaling Pathways Mediated by the TNF- and Cytokine-Receptor Families Target a Common cis-Element of the IFN Regulatory Factor 1 Promoter by Gupta, Sanjay, Xia, Dengfeng, Jiang, Man, Lee, Sangjin, Pernis, Alessandra B

“…CD40 activation of B cells is strongly influenced by the presence of cytokines. However, the molecular basis for the interplay between these distinct stimuli…”
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Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis by Rao, Deepak A., Gurish, Michael F., Marshall, Jennifer L., Slowikowski, Kamil, Fonseka, Chamith Y., Liu, Yanyan, Donlin, Laura T., Henderson, Lauren A., Wei, Kevin, Mizoguchi, Fumitaka, Teslovich, Nikola C., Weinblatt, Michael E., Massarotti, Elena M., Coblyn, Jonathan S., Helfgott, Simon M., Lee, Yvonne C., Todd, Derrick J., Bykerk, Vivian P., Goodman, Susan M., Pernis, Alessandra B., Ivashkiv, Lionel B., Karlson, Elizabeth W., Nigrovic, Peter A., Filer, Andrew, Buckley, Christopher D., Lederer, James A., Raychaudhuri, Soumya, Brenner, Michael B.

“…The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues…”
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Jak-STAT Signaling Induced by the v-abl Oncogene by Danial, Nika N., Pernis, Alessandra, Rothman, Paul B.

“…The effect of the v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) on the Jak-STAT pathway of cytokine signal transduction was investigated. In…”
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Estrogen and CD4+ T cells by Pernis, Alessandra B

“…PURPOSE OF REVIEWMany autoimmune rheumatic autoimmune disorders predominantly affect women. Sex hormones, in particular estrogen, can influence CD4 T-helper…”
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Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells by PERNIS, A, SANJAY GUPTA, GOLLOB, K. J, GARFEIN, E, COFFMAN, R. L, SCHINDLER, C, ROTHMAN, P

“…The ability of interferon gamma (IFN-gamma) to inhibit the proliferation of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells, suggests that…”
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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice by Biswas, Partha S, Gupta, Sanjay, Chang, Emily, Song, Li, Stirzaker, Roslynn A, Liao, James K, Bhagat, Govind, Pernis, Alessandra B

“…Deregulated production of IL-17 and IL-21 plays a key pathogenic role in many autoimmune disorders. A delineation of the mechanisms that underlie the…”
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