Search Results - "Pernía, Olga"

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice by Diz-Chaves, Yolanda, Pernía, Olga, Carrero, Paloma, Garcia-Segura, Luis M

“…Stress during fetal life increases the risk of affective and immune disorders later in life. The altered peripheral immune response caused by prenatal stress…”
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Selective Estrogen Receptor Modulators Decrease Reactive Astrogliosis in the Injured Brain: Effects of Aging and Prolonged Depletion of Ovarian Hormones by Barreto, George, Santos-Galindo, María, Diz-Chaves, Yolanda, Pernía, Olga, Carrero, Paloma, Azcoitia, Iñigo, Garcia-Segura, Luis M

“…After brain injury, astrocytes acquire a reactive phenotype characterized by a series of morphological and molecular modifications, including the expression of…”
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Evaluation of the clinical use of MGMT methylation in extracellular vesicle-based liquid biopsy as a tool for glioblastoma patient management by Rosas-Alonso, Rocío, Colmenarejo-Fernández, Julian, Pernía, Olga, Burdiel, Miranda, Rodríguez-Antolín, Carlos, Losantos-García, Itsaso, Rubio, Tania, Moreno-Velasco, Rocío, Esteban-Rodríguez, Isabel, Martínez-Marín, Virginia, Yubero, Paloma, Costa-Fraga, Nicolas, Díaz-Lagares, Angel, López-López, Rafael, Díaz-Martin, Eva, García, Juan F., Sánchez, Catalina Vivancos, Gandía-González, Maria Luisa, Moreno-Bueno, Gema, de Castro, Javier, de Cáceres, Inmaculada Ibánez

“…Glioblastoma (GB) is a devastating tumor of the central nervous system characterized by a poor prognosis. One of the best-established predictive biomarker in…”
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Short-Term High-Fat Diet Feeding Provides Hypothalamic but Not Hippocampal Protection against Acute Infection in Male Mice by Astiz, Mariana, Pernía, Olga, Barrios, Vicente, Garcia-Segura, Luis Miguel, Diz-Chaves, Yolanda

“…Obesity is associated with increased fever and sickness behavior in response to infection. The hypothalamic-pituitary-adrenal (HPA) axis plays a key role in…”
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miR-7 methylation as a biomarker to predict poor survival in early-stage non-small cell lung cancer patients by Rodríguez-Antolín, Carlos, Felguera-Selas, Laura, Pernía, Olga, Vera, Olga, Esteban, Isabel, Losantos García, Itsaso, de Castro, Javier, Rosas-Alonso, Rocío, Ibanez de Caceres, Inmaculada

“…Non-small-cell lung cancer (NSCLC) is the most common malignancy worldwide. Platinum-based chemotherapy is the standard of care for these patients. Recent…”
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Hypermethylation of Anti-oncogenic MicroRNA 7 is Increased in Emphysema Patients by Rosas-Alonso, Rocío, Galera, Raúl, Sánchez-Pascuala, Joan José, Casitas, Raquel, Burdiel, Miranda, Martínez-Cerón, Elisabet, Vera, Olga, Rodriguez-Antolin, Carlos, Pernía, Olga, De Castro, Javier, García-Rio, Francisco, Ibanez-de-Cáceres, Inmaculada

“…[Display omitted] MicroRNA-7 (miR-7) has a suppressive role in lung cancer and alterations in its DNA methylation may contribute to tumorigenesis. As COPD…”
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Functional analysis of new variants at the low‐density lipoprotein receptor associated with familial hypercholesterolemia by Rodríguez‐Jiménez, Carmen, Pernía, Olga, Mostaza, Jose, Rodríguez‐Antolín, Carlos, Dios García‐Díaz, Juan, Alonso‐Cerezo, Concepción, García‐Polo, Iluminada, Blanco, Agustín, Lahoz, Carlos, Arrieta, Francisco, Beltrán, Luis, Díaz de Bustamante, Aránzazu, Garzón‐Lorenzo, Lucía, Álvarez‐Sala, Luis Antonio, Asenjo, Ángel, Ibáñez de Cáceres, Inmaculada, Rodríguez‐Nóvoa, Sonia

“…Familial hypercholesterolemia is an autosomal dominant disease of lipid metabolism caused by defects in the genes LDLR, APOB, and PCSK9. The prevalence of…”
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Behavioral effects of estradiol therapy in ovariectomized rats depend on the age when the treatment is initiated by Diz-Chaves, Yolanda, Kwiatkowska-Naqvi, Anita, Von Hülst, Hendrik, Pernía, Olga, Carrero, Paloma, Garcia-Segura, Luis M.

“…Clinical studies suggest that aging may affect the neural outcome of estrogen therapy in postmenopausal women. In this study we have assessed whether age…”
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MiR-151a: a robust endogenous control for normalizing small extracellular vesicle cargo in human cancer by Burdiel, Miranda, Jiménez, Julia, Rodríguez-Antolín, Carlos, García-Guede, Ãlvaro, Pernía, Olga, Sastre-Perona, Ana, Rosas-Alonso, Rocío, Colmenarejo, Julián, Rodríguez-Jiménez, Carmen, Diestro, María Dolores, Martínez-Marín, Virginia, Higueras, Oliver, Cruz, Patricia, Losantos-García, Itsaso, Peinado, Héctor, Vera, Olga, de Castro, Javier, Ibáéez de Cáceres, Inmaculada

“…Abstract Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating…”
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Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer by Soto, Javier Andrés, Rodríguez-Antolín, Carlos, Vera, Olga, Pernía, Olga, Esteban-Rodríguez, Isabel, Dolores Diestro, Maria, Benitez, Javier, Sánchez-Cabo, Fátima, Alvarez, Rafael, De Castro, Javier, Ibanez de Cáceres, Inmaculada

“…In an effort to contribute to overcoming the platinum resistance exhibited by most solid tumors, we performed an array of epigenetic approaches, integrating…”
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Metformin: a new option in cancer treatment by Belda-Iniesta, Cristóbal, Pernía, Olga, Simó, Rafael

“…Metformin is a biguanine, the most widely used antidiabetic drug for the treatment of type 2 diabetes. Some studies suggest that metformin decreases the…”
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Methylation status of IGFBP-3 as a useful clinical tool for deciding on a concomitant radiotherapy by Pernía, Olga, Belda-Iniesta, Cristobal, Pulido, Veronica, Cortes-Sempere, María, Rodriguez, Carlos, Vera, Olga, Soto, Javier, Jiménez, Julia, Taus, Alvaro, Rojo, Federico, Arriola, Edurne, Rovira, Ana, Albanell, Joan, Macías, M Teresa, de Castro, Javier, Perona, Rosario, Ibañez de Caceres, Inmaculada

“…The methylation status of the IGFBP-3 gene is strongly associated with cisplatin sensitivity in patients with non-small cell lung cancer (NSCLC). In this…”
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Biomarkers of erlotinib response in non-small cell lung cancer tumors that do not harbor the more common epidermal growth factor receptor mutations by López-Ayllón, Blanca D, de Castro-Carpeño, Javier, Rodriguez, Carlos, Pernía, Olga, Ibañez de Cáceres, Inmaculada, Belda-Iniesta, Cristobal, Perona, Rosario, Sastre, Leandro

“…Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung cancers, which are the leading cause of cancer-related deaths in the world…”
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Pubertal maturation modifies the regulation of insulin‐like growth factor‐I receptor signaling by estradiol in the rat prefrontal cortex by Sanz, Amaya, Carrero, Paloma, Carrero, Paloma, Pernía, Olga, Garcia‐Segura, Luis M.

“…The transition from adolescence to adulthood is accompanied by substantial plastic modifications in the cerebral cortex, including changes in the growth and…”
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Progesterone regulates the phosphorylation of protein phosphatases in the brain by Amorim, Miguel A.R., Guerra-Araiza, Christian, Pernía, Olga, da Cruz e Silva, Edgar F., Garcia-Segura, Luis M.

“…Previous studies have shown that progesterone modulates the activity of different kinases and the phosphorylation of Tau in the brain. These actions of…”
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miR-124 as a Liquid Biopsy Prognostic Biomarker in Small Extracellular Vesicles from NSCLC Patients by Sanchez-Cabrero, Darío, Garcia-Guede, Álvaro, Burdiel, Miranda, Pernía, Olga, Colmenarejo-Fernandez, Julián, Gutierrez, Laura, Higuera, Oliver, Rodriguez, Isabel Esteban, Rosas-Alonso, Rocío, Rodriguez-Antolín, Carlos, Losantos-García, Itsaso, Vera, Olga, De Castro-Carpeño, Javier, Ibanez de Caceres, Inmaculada

“…Despite advances in non-small cell lung cancer (NSCLC) research, this is still the most common cancer type that has been diagnosed up to date. microRNAs have…”
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Prognostic Impact of Dihydropyrimidine Dehydrogenase Germline Variants in Unresectable Non-Small Cell Lung Cancer Patients Treated with Platin-Based Chemotherapy by Guijarro-Eguinoa, Javier, Arjona-Hernandez, Sara, Stewart, Stefan, Pernia, Olga, Arias, Pedro, Losantos-García, Itsaso, Rubio, Tania, Burdiel, Miranda, Rodriguez-Antolin, Carlos, Cruz-Castellanos, Patricia, Higuera, Oliver, Borobia, Alberto M, Rodriguez-Novoa, Sonia, de Castro-Carpeño, Javier, Ibanez de Caceres, Inmaculada, Rosas-Alonso, Rocio

“…Platin-based chemotherapy is the standard treatment for patients with non-small cell lung cancer (NSCLC). However, resistance to this therapy is a major…”
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DNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through MAFG Overexpression in Cancer Cells by Vera, Olga, Jimenez, Julia, Pernia, Olga, Rodriguez-Antolin, Carlos, Rodriguez, Carmen, Sanchez Cabo, Fatima, Soto, Javier, Rosas, Rocio, Lopez-Magallon, Sara, Esteban Rodriguez, Isabel, Dopazo, Ana, Rojo, Federico, Belda, Cristobal, Alvarez, Rafael, Valentin, Jaime, Benitez, Javier, Perona, Rosario, De Castro, Javier, Ibanez de Caceres, Inmaculada

“…One of the major limitations associated with platinum use is the resistance that almost invariably develops in different tumor types. In the current study, we…”
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Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs by Tapia-Gonzalez, Silvia, Carrero, Paloma, Pernia, Olga, Garcia-Segura, Luis M, Diz-Chaves, Yolanda

“…It has been previously reported that the neuroprotective hormone oestradiol reduces microglia inflammatory activity. The objective of this study was to test…”
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High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response by Arrizabalaga, Olatz, Moreno-Cugnon, Leire, Auzmendi-Iriarte, Jaione, Aldaz, Paula, Ibanez de Caceres, Inmaculada, Garros-Regulez, Laura, Moncho-Amor, Veronica, Torres-Bayona, Sergio, Pernía, Olga, Pintado-Berninches, Laura, Carrasco-Ramirez, Patricia, Cortes-Sempere, María, Rosas, Rocío, Sanchez-Gomez, Pilar, Ruiz, Irune, Caren, Helena, Pollard, Steven, Garcia, Idoia, Sacido, Angel-Ayuso, Lovell-Badge, Robin, Belda-Iniesta, Cristobal, Sampron, Nicolas, Perona, Rosario, Matheu, Ander

“…The elucidation of mechanisms involved in resistance to therapies is essential to improve the survival of patients with malignant gliomas. A major feature…”
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