Search Results - "Perni, R. B"

Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease by Lin, C, Kwong, A D, Perni, R B

“…The hepatitis C virus (HCV) NS3.4A protease, which is essential for viral replication, is considered one of the most attractive targets for developing novel…”
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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms by Lin, Chao, Lin, Kai, Luong, Yu-Ping, Rao, B Govinda, Wei, Yun-Yi, Brennan, Debra L, Fulghum, John R, Hsiao, Hsun-Mei, Ma, Sue, Maxwell, John P, Cottrell, Kevin M, Perni, Robert B, Gates, Cynthia A, Kwong, Ann D

“…We have used a structure-based drug design approach to identify small molecule inhibitors of the hepatitis C virus (HCV) NS3.4A protease as potential…”
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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives by Perni, Robert B, Wentland, Mark P, Huang, Jianhua I, Powles, Ronald G, Aldous, Suzanne, Klingbeil, Kristina M, Peverly, A. Danielle, Robinson, Ronald G, Corbett, Thomas H, Jones, Julie L, Mattes, Kenneth C, Rake, James B, Coughlin, Susan A

“…Two new series of antitumor agents, 4-aminomethylthioxanthenones (6 − 50) and 5-aminomethylbenzothiopyranoindazoles (51 − 61), are described and compared…”
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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents by Reuman, Michael, Daum, Sol J, Singh, Baldev, Wentland, Mark P, Perni, Robert B, Pennock, Patrick, Carabateas, Philip M, Gruett, Monte D, Saindane, Manohar T, Dorff, Peter H, Coughlin, Susan A, Sedlock, David M, Rake, James B, Lesher, George Y

“…The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has…”
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Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine by King, R W, Ladner, S K, Miller, T J, Zaifert, K, Perni, R B, Conway, S C, Otto, M J

“…ERRATUM ( vol. 43 , p. 726 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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3-Quinolinecarboxamides. A series of novel orally-active antiherpetic agents by Wentland, Mark P, Perni, Robert B, Dorff, Peter H, Brundage, R. Pauline, Castaldi, Michael J, Bailey, Thomas R, Carabateas, Philip M, Bacon, Edward R, Young, Dorothy C

“…A series of novel 3-quinolinecarboxamides that are structurally similar to the quinolone class of antibacterial agents possess excellent antiherpetic…”
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Phenylpropenamide derivatives as inhibitors of Hepatitis B virus replication by Perni, Robert B, Conway, Samuel C, Ladner, Stephanie K, Zaifert, Katie, Otto, Michael J, King, Robert W

“…A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted…”
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Cyclic Variations of 3-Quinolinecarboxamides and Effects on Antiherpetic Activity by Wentland, Mark P, Carlson, John A, Dorff, Peter H, Aldous, Suzanne C, Perni, Robert B, Young, Dorothy C, Woods, Maureen G, Kingsley, Susan D, Ryan, Kathryn A, Rosi, David, Drozd, Marion L, Dutko, Frank J

“…Supported by the antiherpetic properties of 3-quinolinecarboxamides and the importance of the planar intramolecular H-bonded beta-keto amide pharmacophore, a…”
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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative by Wentland, Mark P, Perni, Robert B, Dorff, Peter H, Rake, James B

“…A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared…”
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Solid sorbent for sampling acrolein in air by Gold, Avram, Dube, C. E, Perni, R. B

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An enantioselective and highly convergent synthesis of (+)-ikarugamycin by Boeckman, Robert K, Weidner, Charles H, Perni, Robert B, Napier, James J

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Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease by PERNI, Robert B, ALMQUIST, Susan J, HEISER, Angela, KALKERI, Gururaj, KOLACZKOWSKI, Elaine, KAI LIN, LUONG, Yu-Ping, GOVINDA RAO, B, TAYLOR, William P, THOMSON, John A, TUNG, Roger D, YUNYI WEI, BYRN, Randal A, KWONG, Ann D, CHAO LIN, CHANDORKAR, Gurudatt, CHATURVEDI, Pravin R, COURTNEY, Lawrence F, DECKER, Caroline J, DINEHART, Kirk, GATES, Cynthia A, HARBESON, Scott L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061 by Lin, Chao, Gates, Cynthia A., Rao, B. Govinda, Brennan, Debra L., Fulghum, John R., Luong, Yu-Ping, Frantz, J. Daniel, Lin, Kai, Ma, Sue, Wei, Yun-Yi, Perni, Robert B., Kwong, Ann D.

“…VX-950 is a potent, small molecule, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3·4A serine protease and has recently been shown to possess…”
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4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: Novel antiarrhythmic agents by Johnson, Robert E, Baizman, Eugene R, Becker, Carolyn, Bohnet, Eric A, Bell, Rebecca H, Birsner, Nancy C, Busacca, Carl A, Carabateas, Philip M, Chadwick, Christopher C

“…A series of 4,5-dihydro-1-phenyl-1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that interact with sodium and potassium channels…”
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Synthesis of .alpha.-substituted 1,2-benzenedimethanamines by Johnson, Robert E, Hane, Jeffrey T, Schlegel, Donald C, Perni, Robert B, Herrmann, John L, Opalka, Chester J, Carabateas, Philip M, Ackerman, James H, Swestock, John

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Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)β-l-2'3'-dideoxy-3'-thiacytidine by KING, R. W, LADNER, S. K, MILLER, T. J, ZAIFERT, K, PERNI, R. B, CONWAY, S. C, OTTO, M. J

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NS3.4A protease as a target for interfering with hepatitis C virus replication by Perni, R B

“…The hepatitis C virus (HCV) epidemic represents a significant unmet medical need. Current treatment is arduous and less than 50% effective. Indeed,…”
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Twin benzoannulation of naphthalene via 1,3-, 1,6-, and 2,6-naphthodiyne synthetic equivalents: new syntheses of triphenylene, benz[a]anthracene, and naphthacene by GRIBBLE, G. W, PERNI, R. B, ONAN, K. D

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Studies directed toward the synthesis of naturally occurring acyltetramic acids. II: Preparation of the macrocyclic subunit of ikarugamycin by BOECKMAN, R. K. JR, PERNI, R. B

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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropyl-quinolone derivative by Wentland, M P, Perni, R B, Dorff, PH, Rake, J B

“…A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared…”
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