Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge

Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge

Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lip...

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Bibliographic Details
Published in:Infection and Immunity Vol. 74; no. 3; pp. 1958 - 1961
Main Authors: Treviño, Sylvia R, Permenter, Amy R, England, Marilyn J, Parthasarathy, Narayanan, Gibbs, Paul H, Waag, David M, Chanh, Tran C
Format: Journal Article
Language:English
Published: Washington, DC American Society for Microbiology 01-03-2006
Subjects:
Aerosols
Animals
Antibodies, Bacterial - administration & dosage
Antibodies, Bacterial - immunology
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - immunology
Applied microbiology
Bacteriology
Biological and medical sciences
Burkholderia mallei
Burkholderia mallei - immunology
Fundamental and applied biological sciences. Psychology
Glanders - immunology
Glanders - mortality
Glanders - prevention & control
Mice
Mice, Inbred BALB C
Microbial Immunity and Vaccines
Microbiology
Miscellaneous
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vertebrata
Mammalia
Microbiology
Mouse
Rodentia
Bacteria
Burkholderia mallei
Monoclonal antibody
Immunity
Inhalation
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Summary:Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Editor: J. B. Bliska
Corresponding author. Mailing address: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21702-5001. Phone: (301) 619-4893. Fax: (301) 619-2152. E-mail: david.waag@det.amedd.army.mil.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.74.3.1958-1961.2006