Search Results - "Perlow, D S"

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide by EMINI, E. A, HUGHES, J. V, PERLOW, D. S, BOGER, J

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Nonpeptide oxytocin antagonists: Analogs of L-371,257 with improved potency by Williams, Peter D., Bock, Mark G., Evans, Ben E., Freidinger, Roger M., Gallicchio, Steven N., Guidotti, Maribeth T., Jacobson, Marlene A., Kuo, Michelle S., Levy, Michelle R., Lis, Edward V., Michelson, Stuart R., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Quigley, Amy G., Reiss, Duane R., Salvatore, Christopher, Stauffer, Kenneth J., Woyden, Carla J.

“…Structure-activity studies on the oxytocin antagonist 1 (L-371,257; K i = 9.3 nM) have led to the identification of a related series of compounds containing an…”
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Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1- R-(pyridyl)ethyl ether terminus by Kuo, Michelle S., Bock, Mark G., Freidinger, Roger M., Guidotti, Maribeth T., Lis, Edward V., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Quigley, Amy G., Reiss, Duane R., Williams, Peter D., Woyden, Carla J.

“…Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which…”
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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine by Boger, Joshua, Payne, Linda S, Perlow, Debra S, Lohr, Nancy S, Poe, Martin, Blaine, Edward H, Ulm, Edgar H, Schorn, Terry W, LaMont, Bruce I

“…Analogues of the renin octapeptide substrate were synthesized in which replacement of the scissile dipeptide with (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic…”
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Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product by Williams, Peter D, Bock, Mark G, Tung, Roger D, Garsky, Victor M, Perlow, Debra S, Erb, Jill M, Lundell, G. F, Gould, Norman P, Whitter, Willie L

“…A new structural class of cyclic hexapeptide oxytocin antagonists derived from Streptomyces silvensis and typified by L-365,209…”
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Conformationally constrained tachykinin analogs which are selective ligands for the eledoisin binding site by Cascieri, M A, Chicchi, G G, Freidinger, R M, Colton, C D, Perlow, D S, Williams, B, Curtis, N R, McKnight, A T, Maguire, J J, Veber, D F

“…We have prepared a series of conformationally constrained hexapeptide analogs of substance P which are 500-1500-fold more potent as inhibitors of 125I-labeled…”
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The selectivity of statine-based inhibitors against various human aspartic proteinases by Jupp, R A, Dunn, B M, Jacobs, J W, Vlasuk, G, Arcuri, K E, Veber, D F, Perlow, D S, Payne, L S, Boger, J, de Laszlo, S

“…The interactions of five human enzymes (renin, pepsin, gastricsin, cathepsin D and cathepsin E) and the aspartic proteinase from Endothia parasitica with…”
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A super active cyclic hexapeptide analog of somatostatin by Veber, D F, Saperstein, R, Nutt, R F, Freidinger, R M, Brady, S F, Curley, P, Perlow, D S, Paleveda, W J, Colton, C D, Zacchei, A G

“…The cyclic hexapeptide, cyclo (Pro-Phe-D-Trp-Lys-Thr-Phe), I, has been shown to have the biological properties of somatostatin. We now report…”
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Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril by GREENLEE, W. J, ALLIBONE, P. L, PERLOW, D. S, PATCHETT, A. A, ULM, E. H, VASSIL, T. C

“…The synthesis and biological activity of a series of inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) are described. Incorporation of the substituted…”
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Design and discovery in the development of long-acting renin inhibitors by Veber, D F, Payne, L S, Williams, P D, Perlow, D S, Lundell, G F, Gould, N P, Siegl, P K, Sweet, C S, Freidinger, R M

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Conformational modifications of cyclic hexapeptide somatostatin analogs by Freidinger, R M, Perlow, D S, Randall, W C, Saperstein, R, Arison, B H, Veber, D F

“…A model for the bioactive conformation of the highly active cyclic hexapeptide somatostatin analog cyclo-(Pro-Phe-D-Trp-Lys-Thr-Phe) has been proposed. As a…”
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Protected lactam-bridged dipeptides for use as conformational constraints in peptides by Freidinger, Roger M, Perlow, Debra Schwenk, Veber, Daniel F

“…General methods have been devised for the synthesis of lactam-constrained dipeptide analogues having five-, six-, and seven-membered rings. Three different…”
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Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog by Freidinger, Roger M., Veber, Daniel F., Perlow, Debra Schwenk, Brooks, Jerry R., Saperstein, Richard

“…An analog of luteinizing hormone-releasing hormone containing a γ -lactam as a conformational constraint has been prepared with the use of a novel cyclization…”
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A potent cyclic hexapeptide analogue of somatostatin by Veber, Daniel F, Freidinger, Roger M, Perlow, Debra Schwenk, Paleveda, William J, Holly, Frederick W, Strachan, Robert G, Nutt, Ruth F, Arison, Byron H, Homnick, Carl, Randall, William C, Glitzer, Monroe S, Saperstein, Richard, Hirschmann, Ralph

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Use of N-Fmoc amino acid chlorides and activated 2-(fluorenylmethoxy)-5(4H)-oxazolones in solid-phase peptide synthesis. Efficient syntheses of highly N-alkylated cyclic hexapeptide oxytocin antagonists related to L-365,209 by Perlow, Debra S, Erb, Jill M, Gould, Norman P, Tung, Roger D, Freidinger, Roger M, Williams, Peter D, Veber, Daniel F

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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics by Williams, Peter D, Perlow, Debra S, Payne, Linda S, Holloway, M. Katherine, Siegl, Peter K. S, Schorn, Terry W, Lynch, Robert J, Doyle, John J, Strouse, John F

“…A series of renin inhibitors containing lactam-bridged P1-P1' dipeptide mimetics based on the ACHPA (4(S)-amino-5-cyclohexyl-3(S)-hydroxypentanoic acid) design…”
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Synthesis of new peptides based on models of receptor-bound conformation by Freidinger, R M, Brady, S F, Paleveda, W J, Perlow, D S, Colton, C D, Whitter, W L, Saperstein, R, Brady, E J, Cascieri, M A, Veber, D F

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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells by Embrey, Mark W., Wai, John S., Funk, Timothy W., Homnick, Carl F., Perlow, Debbie S., Young, Steven D., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Moyer, Gregory, Schleif, William A., Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Ellis, Joan D., Wong, Bradley K., Lin, Jiunn H., Leonard, Yvonne M., Tsou, Nancy N., Zhuang, Linghang

“…Introduction of a 5,6-dihydrouracil functionality in the 5-position of N-(4-fluorobenzyl)-8-hydroxy-[1,6]naphthyridine-7-carboxamide 1 led to a series of…”
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Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation by Williams, P D, Ball, R G, Clineschmidt, B V, Culberson, J C, Erb, J M, Freidinger, R M, Pawluczyk, J M, Perlow, D S, Pettibone, D J, Veber, D F

“…A series of new o-tolylpiperazine camphorsulfonamide OT antagonists is described. Analogs containing conformationally constrained 1-acylamino-2-propyl…”
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Nanomolar-affinity, non-peptide oxytocin receptor antagonists by Evans, Ben E, Lundell, George F, Gilbert, Kevin F, Bock, Mark G, Rittle, Kenneth E, Carroll, Leigh Anne, Williams, Peter D, Pawluczyk, Joseph M, Leighton, James L

“…Non-peptide antagonists of the peptide hormone oxytocin (OT) with nanomolar OT receptor affinities are described. These compounds incorporate novel amido- and…”
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