Nodular sarcoidosis of the liver and spleen: analysis of 32 cases

To describe the computed tomographic (CT) appearance of nodular hepatosplenic sarcoidosis and its association with stage with chest radiography and clinical status. Thirty-two patients (21 women, 11 men; aged 25-68 years) with nodular hepatosplenic sarcoidosis were evaluated. CT findings were descri...

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Bibliographic Details
Published in:	Radiology Vol. 195; no. 3; p. 757
Main Authors:	Warshauer, D M, Molina, P L, Hamman, S M, Koehler, R E, Paulson, E K, Bechtold, R E, Perlmutter, M L, Hiken, J N, Francis, I R, Cooper, C J
Format:	Journal Article
Language:	English
Published:	United States 01-06-1995
Subjects:	Adult Aged Female Humans Liver Diseases - diagnostic imaging Liver Diseases - enzymology Male Middle Aged Peptidyl-Dipeptidase A - blood Radiography, Thoracic Sarcoidosis - diagnostic imaging Sarcoidosis - enzymology Splenic Diseases - diagnostic imaging Splenic Diseases - enzymology Tomography, X-Ray Computed
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Summary:	To describe the computed tomographic (CT) appearance of nodular hepatosplenic sarcoidosis and its association with stage with chest radiography and clinical status. Thirty-two patients (21 women, 11 men; aged 25-68 years) with nodular hepatosplenic sarcoidosis were evaluated. CT findings were described along with chest radiographic stage, clinical status, and level of angiotensin-converting enzyme (ACE). Nodules were small, multiple, and of low attenuation. Organomegaly was common. Abdominal adenopathy was present in 76% of the patients. Chest radiographs were normal in 25%; 61% had stage 1 or 2 radiographs. Abdominal or systemic symptoms were present in 66%. ACE level was elevated in 10 (91%) of 11 patients tested. No change in chest radiographic stage was noted in 74% of patients with follow-up radiographs. Nodular hepatosplenic sarcoidosis is associated with organomegaly, adenopathy, and symptoms. Nodules were not associated with advanced lung disease and did not herald a change in chest radiographic stage. An elevated ACE level may be helpful in diagnosis.
ISSN:	0033-8419
DOI:	10.1148/radiology.195.3.7754007