Search Results - "Perlman, Stanley"

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology by Channappanavar, Rudragouda, Perlman, Stanley

“…Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic coronaviruses. The low pathogenic CoVs infect the upper respiratory tract…”
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T cell-mediated immune response to respiratory coronaviruses by Channappanavar, Rudragouda, Zhao, Jincun, Perlman, Stanley

“…Emerging respiratory coronaviruses such as the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus…”
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Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity by Channappanavar, Rudragouda, Perlman, Stanley

“…Human coronaviruses (hCoVs) cause severe respiratory illness in the elderly. Age-related impairments in innate immunity and suboptimal virus-specific T cell…”
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Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 by Lowery, Shea A., Sariol, Alan, Perlman, Stanley

“…COVID-19 can result in severe disease characterized by significant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response…”
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Middle East respiratory syndrome by Zumla, Alimuddin, Prof, Hui, David S, Prof, Perlman, Stanley, Prof

“…Summary Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel single-stranded, positive-sense RNA betacoronavirus…”
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Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy? by Wong, Lok-Yin Roy, Perlman, Stanley

“…Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds to acute respiratory distress syndrome and death. Three highly pathogenic…”
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Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus by Fehr, Anthony R, Channappanavar, Rudragouda, Perlman, Stanley

“…In 2012, a zoonotic coronavirus was identified as the causative agent of Middle East respiratory syndrome and was named MERS coronavirus (MERS-CoV). As of…”
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Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection by Qing, Enya, Hantak, Michael, Perlman, Stanley, Gallagher, Tom

“…Coronaviruses (CoVs) are common human and animal pathogens that can transmit zoonotically and cause severe respiratory disease syndromes. CoV infection…”
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Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses by Perlman, Stanley

“…  The second major discovery was that another type of T cell, the CD4 T cell, was the major factor in host tissue damage in MHV-infected mice, and that…”
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T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice by Zhao, Jincun, Zhao, Jingxian, Perlman, Stanley

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Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection by Channappanavar, Rudragouda, Fett, Craig, Mack, Matthias, Ten Eyck, Patrick P, Meyerholz, David K, Perlman, Stanley

“…Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome-CoV, cause acute…”
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Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells by Zheng, Jian, Wang, Yuhang, Li, Kun, Meyerholz, David K, Allamargot, Chantal, Perlman, Stanley

“…Abstract Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected patients and experimentally infected animals indicate a critical role…”
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Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice by Channappanavar, Rudragouda, Fehr, Anthony R., Vijay, Rahul, Mack, Matthias, Zhao, Jincun, Meyerholz, David K., Perlman, Stanley

“…Highly pathogenic human respiratory coronaviruses cause acute lethal disease characterized by exuberant inflammatory responses and lung damage. However, the…”
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COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice by Zheng, Jian, Wong, Lok-Yin Roy, Li, Kun, Verma, Abhishek Kumar, Ortiz, Miguel E., Wohlford-Lenane, Christine, Leidinger, Mariah R., Knudson, C. Michael, Meyerholz, David K., McCray, Paul B., Perlman, Stanley

“…The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial morbidity and mortality. Although much has been learned in the first…”
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A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry by SHULLA, Ana, HEALD-SARGENT, Taylor, SUBRAMANYA, Gitanjali, JINCUN ZHAO, PERLMAN, Stanley, GALLAGHER, Tom

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Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 by NETLAND, Jason, MEYERHOLZ, David K, MOORE, Steven, CASSELL, Martin, PERLMAN, Stanley

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3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice by Rathnayake, Athri D, Zheng, Jian, Kim, Yunjeong, Perera, Krishani Dinali, Mackin, Samantha, Meyerholz, David K, Kashipathy, Maithri M, Battaile, Kevin P, Lovell, Scott, Perlman, Stanley, Groutas, William C, Chang, Kyeong-Ok

“…Pathogenic coronaviruses are a major threat to global public health, as exemplified by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East…”
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Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity by Heer, Collin D., Sanderson, Daniel J., Voth, Lynden S., Alhammad, Yousef M.O., Schmidt, Mark S., Trammell, Samuel A.J., Perlman, Stanley, Cohen, Michael S., Fehr, Anthony R., Brenner, Charles

“…Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the…”
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Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism by Park, Jung-Eun, Li, Kun, Barlan, Arlene, Fehr, Anthony R., Perlman, Stanley, McCray, Paul B., Gallagher, Tom

“…Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans from zoonotic sources and causes severe pulmonary disease. Virions require spike (S)…”
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The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression by Grunewald, Matthew E, Chen, Yating, Kuny, Chad, Maejima, Takashi, Lease, Robert, Ferraris, Dana, Aikawa, Masanori, Sullivan, Christopher S, Perlman, Stanley, Fehr, Anthony R

“…ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases,…”
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