Search Results - "Perlin, David S."

Mechanisms of echinocandin antifungal drug resistance by Perlin, David S.

“…Fungal infections due to Candida and Aspergillus species cause extensive morbidity and mortality, especially among immunosuppressed patients, and antifungal…”
Get full text

The global problem of antifungal resistance: prevalence, mechanisms, and management by Perlin, David S, Rautemaa-Richardson, Riina, Alastruey-Izquierdo, Ana

“…All serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the…”
Get full text

Echinocandin Resistance, Susceptibility Testing and Prophylaxis: Implications for Patient Management by Perlin, David S.

“…This article addresses the emergence of echinocandin resistance among Candida species, mechanisms of resistance, factors that promote resistance and…”
Get full text

Identification of Drug Resistant Candida auris by Kordalewska, Milena, Perlin, David S

“…is a multidrug resistant yeast, recognized as a cause of invasive infections and health care associated outbreaks around the world. is of great public health…”
Get full text

COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From immunology to treatment by Arastehfar, Amir, Carvalho, Agostinho, van de Veerdonk, Frank L., Jenks, Jeffrey D., Koehler, Philipp, Krause, Robert, Cornely, Oliver A., S. Perlin, David, Lass-Flörl, Cornelia, Hoenigl, Martin

“…Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome (ARDS) has emerged as an important disease that…”
Get full text

Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris by Kordalewska, Milena, Lee, Annie, Park, Steven, Berrio, Indira, Chowdhary, Anuradha, Zhao, Yanan, Perlin, David S

“…has simultaneously emerged on five continents as a fungal pathogen causing nosocomial outbreaks. The challenges in the treatment of infections are the variable…”
Get full text

Rapid and Accurate Molecular Identification of the Emerging Multidrug-Resistant Pathogen Candida auris by Kordalewska, Milena, Zhao, Yanan, Lockhart, Shawn R, Chowdhary, Anuradha, Berrio, Indira, Perlin, David S

“…is an emerging multidrug-resistant fungal pathogen causing nosocomial and invasive infections associated with high mortality. is commonly misidentified as…”
Get full text

The importance of antimicrobial resistance in medical mycology by Gow, Neil A. R., Johnson, Carolyn, Berman, Judith, Coste, Alix T., Cuomo, Christina A., Perlin, David S., Bicanic, Tihana, Harrison, Thomas S., Wiederhold, Nathan, Bromley, Mike, Chiller, Tom, Edgar, Keegan

“…Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O’Neill report, have…”
Get full text

Coping with stress and the emergence of multidrug resistance in fungi by Shor, Erika, Perlin, David S

“…  Factors that contribute to this disease burden and high mortality include insufficient diagnostics and treatment, and the increasing numbers of individuals…”
Get full text

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata by Healey, Kelley R, Perlin, David S

“…has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the…”
Get full text

Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance by Arastehfar, Amir, Daneshnia, Farnaz, Cabrera, Nathaly, Penalva-Lopez, Suyapa, Sarathy, Jansy, Zimmerman, Matthew, Shor, Erika, Perlin, David S.

“…Candida glabrata is a major fungal pathogen notable for causing recalcitrant infections, rapid emergence of drug-resistant strains, and its ability to survive…”
Get full text

Rapid and quantitative detection of SARS-CoV-2 specific IgG for convalescent serum evaluation by Tan, Xiaotian, Krel, Mila, Dolgov, Enriko, Park, Steven, Li, Xuzhou, Wu, Weishu, Sun, Yun-Lu, Zhang, Jie, Khaing Oo, Maung Kyaw, Perlin, David S., Fan, Xudong

“…Convalescent serum with a high abundance of neutralization IgG is a promising therapeutic agent for rescuing COVID-19 patients in the critical stage. Knowing…”
Get full text

Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans: Implications for Interpretive Breakpoints by GARCIA-EFFRON, Guillermo, PARK, Steven, PERLIN, David S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Reactive oxidant species induced by antifungal drugs: identity, origins, functions, and connection to stress-induced cell death by Gonzalez-Jimenez, Irene, Perlin, David S, Shor, Erika

“…Reactive oxidant species (ROS) are unstable, highly reactive molecules that are produced by cells either as byproducts of metabolism or synthesized by…”
Get full text

COVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions? by Arastehfar, Amir, Carvalho, Agostinho, Nguyen, M. Hong, Hedayati, Mohammad Taghi, Netea, Mihai G., Perlin, David S., Hoenigl, Martin

“…The recent global pandemic of COVID-19 has predisposed a relatively high number of patients to acute respiratory distress syndrome (ARDS), which carries a risk…”
Get full text

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance by Healey, Kelley R., Zhao, Yanan, Perez, Winder B., Lockhart, Shawn R., Sobel, Jack D., Farmakiotis, Dimitrios, Kontoyiannis, Dimitrios P., Sanglard, Dominique, Taj-Aldeen, Saad J., Alexander, Barbara D., Jimenez-Ortigosa, Cristina, Shor, Erika, Perlin, David S.

“…The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles…”
Get full text

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium by Arastehfar, Amir, Gabaldón, Toni, Garcia-Rubio, Rocio, Jenks, Jeffrey D, Hoenigl, Martin, Salzer, Helmut J F, Ilkit, Macit, Lass-Flörl, Cornelia, Perlin, David S

“…The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various…”
Get full text

Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β-d-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint by GARCIA-EFFRON, Guillermo, LEE, Samuel, PARK, Steven, CLEARY, John D, PERLIN, David S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Discovery of MRSA active antibiotics using primary sequence from the human microbiome by Chu, John, Vila-Farres, Xavier, Inoyama, Daigo, Ternei, Melinda, Cohen, Louis J, Gordon, Emma A, Reddy, Boojala Vijay B, Charlop-Powers, Zachary, Zebroski, Henry A, Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Park, Steven, Perlin, David S, Freundlich, Joel S, Brady, Sean F

“…The synthetic bioinformatic natural products (syn-BNPs) approach identifies putative natural products that are validated directly by independent synthesis. Its…”
Get full text

Enfumafungin Derivative MK-3118 Shows Increased In Vitro Potency against Clinical Echinocandin-Resistant Candida Species and Aspergillus Species Isolates by JIMENEZ-ORTIGOSA, Cristina, PADERU, Padmaja, MOTYL, Mary R, PERLIN, David S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text