Search Results - "Perl, Abbey"

Desmosomal Cadherins in Health and Disease by Hegazy, Marihan, Perl, Abbey L, Svoboda, Sophia A, Green, Kathleen J

“…Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes…”
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Desmosomes at a glance by Perl, Abbey L, Pokorny, Jenny L, Green, Kathleen J

“…Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in evolution to ensure the structural integrity of vertebrate tissues by…”
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PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus by Perl, Abbey L., Koetsier, Jennifer L., Green, Kathleen J.

“…Critical for the maintenance of epidermal integrity and function are attachments between intermediate filaments (IF) and intercellular junctions called…”
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Selective PP2A Enhancement through Biased Heterotrimer Stabilization by Leonard, Daniel, Huang, Wei, Izadmehr, Sudeh, O’Connor, Caitlin M., Wiredja, Danica D., Wang, Zhizhi, Zaware, Nilesh, Chen, Yinghua, Schlatzer, Daniela M., Kiselar, Janna, Vasireddi, Nikhil, Schüchner, Stefan, Perl, Abbey L., Galsky, Matthew D., Xu, Wenqing, Brautigan, David L., Ogris, Egon, Taylor, Derek J., Narla, Goutham

“…Impairment of protein phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for the pathogenesis of many diseases,…”
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Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45) by Perl, Abbey L., O’Connor, Caitlin M., Fa, Pengyan, Mayca Pozo, Franklin, Zhang, Junran, Zhang, Youwei, Narla, Goutham

“…Genomic replication is a highly regulated process and represents both a potential benefit and liability to rapidly dividing cells; however, the precise…”
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Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer by McClinch, Kimberly, Avelar, Rita A, Callejas, David, Izadmehr, Sudeh, Wiredja, Danica, Perl, Abbey, Sangodkar, Jaya, Kastrinsky, David B, Schlatzer, Daniela, Cooper, Maxwell, Kiselar, Janna, Stachnik, Agnes, Yao, Shen, Hoon, Divya, McQuaid, Daniel, Zaware, Nilesh, Gong, Yixuan, Brautigan, David L, Plymate, Stephen R, Sprenger, Cynthia C T, Oh, William K, Levine, Alice C, Kirschenbaum, Alexander, Sfakianos, John P, Sears, Rosalie, DiFeo, Analisa, Ioannou, Yiannis, Ohlmeyer, Michael, Narla, Goutham, Galsky, Matthew D

“…Primary prostate cancer is generally treatable by androgen deprivation therapy, however, later recurrences of castrate-resistant prostate cancer (CRPC) that…”
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Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis by Roth-Carter, Quinn R, Burks, Hope E, Ren, Ziyou, Koetsier, Jennifer L, Tsoi, Lam C, Harms, Paul W, Xing, Xianying, Kirma, Joseph, Harmon, Robert M, Godsel, Lisa M, Perl, Abbey L, Gudjonsson, Johann E, Green, Kathleen J

“…Darier, Hailey-Hailey, and Grover diseases are rare acantholytic skin diseases. While these diseases have different underlying causes, they share defects in…”
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Complete Genome of Bacillus subtilis Myophage CampHawk by Ritz, Morgan P, Perl, Abbey L, Colquhoun, Jennifer M, Chamakura, Karthik R, Kuty Everett, Gabriel F

“…The study of bacteriophages infecting the model organism Bacillus subtilis has provided an abundance of general knowledge and a platform for advances in…”
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Complete Genome of Bacillus subtilis Myophage Grass by Miller, Stanton Y, Colquhoun, Jennifer M, Perl, Abbey L, Chamakura, Karthik R, Kuty Everett, Gabriel F

“…Bacillus subtilis is a ubiquitous Gram-positive model organism. Here, we describe the complete genome of B. subtilus myophage Grass. Aside from genes encoding…”
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Therapeutic targeting of PP2A by O’Connor, Caitlin M., Perl, Abbey, Leonard, Daniel, Sangodkar, Jaya, Narla, Goutham

“…Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that regulates many cellular processes. Given the central role of PP2A in regulating…”
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Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth by Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B, Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D, O'Connor, Caitlin M, Hoon, Divya, Dhawan, Neil S, Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C, Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C, Yuan, Eric, Avelar, Rita A, Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M, McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C, Sears, Rosalie C, Chen, Edward Y, Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma'ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D, Brautigan, David L, Ioannou, Yiannis A, Xu, Wenqing, Chance, Mark R, Ohlmeyer, Michael, Narla, Goutham

“…Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have…”
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Abstract 2981: Biased activation of PP2A through selective heterotrimer binding and stabilization by Leonard, Daniel, Huang, Wei, Izadmehr, Sudeh, O'Connor, Caitlin M., Wiredja, Danica D., Wang, Zhizhi, Zaware, Nilesh, Schlatzer, Daniela M., Schuchner, Stefan, Kiselar, Janna, Chen, Yinghua, Vasireddi, Nikhil, Perl, Abbey L., Glasky, Matthew D., Xu, Wenqing, Brautigan, David L., Ogris, Egon, Taylor, Derek J., Narla, Goutham

“…Abstract Development of molecularly targeted therapies have shifted our clinical approach to cancer allowing for an integrated treatment approach where tumor…”
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Leveraging Small Molecule Activators of Protein Phosphatase 2a (Pp2a) to Elucidate PP2As Role in Regulating DNA Replication and Apoptosis by Perl, Abbey Leigh

“…Aberrant signal transduction resulting from dysregulated phosphorylation is a hallmark of human cancer. Altered phosphorylation has broad implications on…”
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Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer by Sangodkar, Jaya, Tohme, Rita, Kiselar, Janna, Izadmehr, Sudeh, Hoon, Divya, Mazhar, Sahar, Perl, Abbey, Wiredja, Danica, Schlatzer, Daniela, Yao, Shen, Kastrinsky, David, Sharma, Neelesh, Brautigan, David, Chance, Mark, Borczuk, Alain, Ohlmeyer, Michael, Ioannou, Yiannis, Narla, Goutham

“…Abstract PP2A is a phosphatase tumor suppressor that is dysregulated and deactivated in lung cancer. It is one of the most abundant cellular proteins and…”
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RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth by Umesalma, Shaikamjad, Kaemmer, Courtney A, Kohlmeyer, Jordan L, Letney, Blake, Schab, Angela M, Reilly, Jacqueline A, Sheehy, Ryan M, Hagen, Jussara, Tiwari, Nitija, Zhan, Fenghuang, Leidinger, Mariah R, O'Dorisio, Thomas M, Dillon, Joseph, Merrill, Ronald A, Meyerholz, David K, Perl, Abbey L, Brown, Bart J, Braun, Terry A, Scott, Aaron T, Ginader, Timothy, Taghiyev, Agshin F, Zamba, Gideon K, Howe, James R, Strack, Stefan, Bellizzi, Andrew M, Narla, Goutham, Darbro, Benjamin W, Quelle, Frederick W, Quelle, Dawn E

“…Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically, but tumor…”
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