Search Results - "Perkins, S.J."

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II) by Licht, C., Heinen, S., Józsi, M., Löschmann, I., Saunders, R.E., Perkins, S.J., Waldherr, R., Skerka, C., Kirschfink, M., Hoppe, B., Zipfel, P.F.

“…We report a novel pathomechanism for membranoproliferative glomerulonephritis type II (MPGN II) caused by a mutant Factor H protein expressed in the plasma…”
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63 Incidence and Determinants of COVID-19 Emergency Department Revisits by Chopra, Z., Holmes, A.R., Nelson, J.R., Hirschl, J.R., Perkins, S.J., Fung, C., Medlin, R.P., Korley, F.K.

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41 Clinical Outcomes among COVID-19 Patients Taking Non-Steroidal Anti-Inflammatory Drugs by Perkins, S.J., Holmes, A.R., Nelson, J.R., Hirschl, J.R., Chopra, Z., Medlin, R., Fung, C., Korley, F.K.

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An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B by Rallapalli, P. M., Kemball‐Cook, G., Tuddenham, E. G., Gomez, K., Perkins, S. J.

“…Summary Background Factor IX (FIX) is important in the coagulation cascade, being activated to FIXa on cleavage. Defects in the human F9 gene frequently lead…”
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Montblanc : GPU accelerated radio interferometer measurement equations in support of Bayesian inference for radio observations by Perkins, S.J., Marais, P.C., Zwart, J.T.L., Natarajan, I., Tasse, C., Smirnov, O.

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Eating disorders and irritable bowel syndrome: is there a link? by Perkins, S.J., Keville, S., Schmidt, U., Chalder, T.

“…The relationship between eating disorders (ED) and irritable bowel syndrome (IBS) is poorly understood. We wanted to determine the prevalence of IBS in a large…”
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Montblanc11https://github.com/ska-sa/montblanc.: GPU accelerated radio interferometer measurement equations in support of Bayesian inference for radio observations by Perkins, S.J., Marais, P.C., Zwart, J.T.L., Natarajan, I., Tasse, C., Smirnov, O.

“…We present Montblanc, a GPU implementation of the Radio interferometer measurement equation (RIME) in support of the Bayesian inference for radio observations…”
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Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome—A pedigree revisited by Johnson, S.A., Williams, J.M., Hakobyan, S., Richards, A., Perkins, S.J., Marchbank, K.J., Goodship, T.H.J., Morgan, B.P., Taylor, C.M., Savage, C.O.S.

“…Atypical hemolytic uremic syndrome (aHUS) is associated with mutations in the gene CFH encoding the complement regulator factor H (CFH). We previously reported…”
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Characterisation of the CCP7 heparin-binding site in human complement factor H: Functional variation in AMD-associated allelic variant by Clark, S.J., Higman, V.A., Mulloy, B., Perkins, S.J., Lea, S., Day, A.J., Sim, R.B.

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The solution structure of human factor B reveals interactions between its domains: A study by NMR and homology modelling by Hinshelwood, J., Perkins, S.J.

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Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling by O'CONNELL, N. M., SAUNDERS, R. E., LEE, C. A., PERRY, D. J., PERKINS, S. J.

“…Background: Factor (F)XI is important in the consolidation phase of blood coagulation. The structural effects of mutations causing FXI deficiency have not been…”
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Autosomal dominant reticulo-endothelial iron overload associated with a three base pair deletion in the ferroportin 1 gene by Devalia, V., Carter, K., Walker, A.P., Perkins, S.J., Worwood, M., May, A., Dooley, J.S.

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Metal-dependent conformational changes in the vWF-A domain from factor B: A study by CD, FT-IR and 1H NMR spectroscopy by Hinshelwood, J., Perkins, S.J.

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Possible arrangement of the five domains in human complement factor I by a combination of X-ray and neutron scattering and homology modelling by Chamberlain, D., Ullman, C.G., Perkins, S.J.

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The compact five-domain structure of factor B of human complement by X-ray and neutron solution scattering and homology modelling by Chamberlain, D., Hinshelwood, J., Perkins, S.J.

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Molecular structures from low angle X-ray and neutron scattering studies by Perkins, S.J, Ashton, A.W, Boehm, M.K, Chamberlain, D

“…Molecular structures can be extracted from solution scattering analyses of multidomain or oligomeric proteins by a new method of constrained automated…”
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Factor X Leicester: Ile411Phe associated with a low antigen level and a disproportionately low functional activity of factor X by Deam, S., Uprichard, J., Eaton, J. T., Perkins, S. J., Dolan, G.

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Different SCR domain arrangements in human factor H and mouse and rat CRRY by X-ray and neutron solution scattering and constrained homology modelling by Aslam, M., Guthridge, J.M., Quigg, R.J., Holers, V.M., Perkins, S.J.

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Structural analysis of recombinant human CD21 ligand binding domains by Guthridge, J.M., Aslam, M., Perkins, S.J., Holers, V.M.

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MeerKAT Primary Beam Models: Derivation and Application In Calibration and Imaging by Smirnov, O.M., Asad, K.M.B., Girard, J.N., Villiers, M. de, Iheanetu, K., Ansah-Narh, T., Makhathini, S., Hugo, B., Santos, M.G., Kenyon, J.S., Perkins, S.J., Tasse, C.

“…We report on holographic measurements of the antenna primary beam (PB) of the MeerKAT radio telescope, an SKA precursor instrument currently being commissioned…”
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