Search Results - "Perkins, Neil D."

NF-κB and the cell cycle by Ledoux, Adeline C, Perkins, Neil D

“…The NF-κB (nuclear factor κB) transcription factor family is a pleiotropic regulator of many cellular pathways, providing a mechanism for the cell to respond…”
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The diverse and complex roles of NF-κB subunits in cancer by Perkins, Neil D.

“…Key Points The nuclear factor-κB (NF-κB)–inhibitor of NF-κB kinase (IKK) pathway can promote the growth and survival of many solid and haematological…”
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Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα by Ivanova, Iglika G, Perkins, Neil D

“…The nuclear factor-κB (NF-κB) family of transcription factors can directly or indirectly regulate many important areas of biology, including immunity,…”
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Identification and Functional Characterization of FMN2, a Regulator of the Cyclin-Dependent Kinase Inhibitor p21 by Yamada, Kayo, Ono, Motoharu, Perkins, Neil D., Rocha, Sonia, Lamond, Angus I.

“…The ARF tumor suppressor is a central component of the cellular defense against oncogene activation in mammals. p14ARF activates p53 by binding and inhibiting…”
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Cysteine 38 Holds the Key to NF-κB Activation by Perkins, Neil D.

“…The importance of parallel signaling pathways controlling NF-κB subunit posttranslational modifications is demonstrated by Sen et al. (2012), who reveal that…”
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Regulation of cyclin D1 gene expression by Witzel, Ini-Isabée, Koh, Li Fang, Perkins, Neil D

“…Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different…”
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A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells by Cuevas-Ocaña, Sara, Yang, Jin Ye, Aushev, Magomet, Schlossmacher, George, Bear, Christine E, Hannan, Nicholas R F, Perkins, Neil D, Rossant, Janet, Wong, Amy P, Gray, Michael A

“…Introducing or correcting disease-causing mutations through genome editing in human pluripotent stem cells (hPSCs) followed by tissue-specific differentiation…”
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RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation by Szołtysek, Katarzyna, Janus, Patryk, Zając, Gracjana, Stokowy, Tomasz, Walaszczyk, Anna, Widłak, Wiesława, Wojtaś, Bartosz, Gielniewski, Bartłomiej, Cockell, Simon, Perkins, Neil D, Kimmel, Marek, Widlak, Piotr

“…The cellular response to ionizing radiation involves activation of p53-dependent pathways and activation of the atypical NF-κB pathway. The crosstalk between…”
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Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence by Iannetti, Alessio, Ledoux, Adeline C, Tudhope, Susan J, Sellier, Hélène, Zhao, Bo, Mowla, Sophia, Moore, Adam, Hummerich, Holger, Gewurz, Benjamin E, Cockell, Simon J, Jat, Parmjit S, Willmore, Elaine, Perkins, Neil D

“…There are two major pathways leading to induction of NF-κB subunits. The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel…”
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Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase by Russell, Lauren G., Davis, Lydia A. K., Hunter, Jill E., Perkins, Neil D., Kenneth, Niall S.

“…The product encoded by the X-linked inhibitor of apoptosis (XIAP) gene is a multi-functional protein which not only controls caspase-dependent cell death, but…”
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Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes by Janus, Patryk, Szołtysek, Katarzyna, Zając, Gracjana, Stokowy, Tomasz, Walaszczyk, Anna, Widłak, Wiesława, Wojtaś, Bartosz, Gielniewski, Bartłomiej, Iwanaszko, Marta, Braun, Rosemary, Cockell, Simon, Perkins, Neil D., Kimmel, Marek, Widlak, Piotr

“…The NF-κB transcription factors are activated via diverse molecular mechanisms in response to various types of stimuli. A plethora of functions associated with…”
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Transcriptional profiling of the LPS induced NF-κB response in macrophages by Sharif, Omar, Bolshakov, Viacheslav N, Raines, Stephanie, Newham, Peter, Perkins, Neil D

“…Abstract Background Exposure of macrophages to bacterial products such as lipopolysaccharide (LPS) results in activation of the NF-κB transcription factor,…”
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Emerging from NF-κB’s Shadow, SUMOylated IκBα Represses Transcription by Perkins, Neil D.

“…In this issue of Cancer Cell, Mulero and colleagues describe an NF-κB independent transcriptional repression function for SUMOylated IκBα. This compelling and…”
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SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1 by Bouras, Toula, Fu, Maofu, Sauve, Anthony A., Wang, Fang, Quong, Andrew A., Perkins, Neil D., Hay, Ronald T., Gu, Wei, Pestell, Richard G.

“…The SIR2 family of nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases modulates diverse biological functions in different species, including…”
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Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor by Al-Jawdah, Abdulmajeed D, Ivanova, Iglika G, Waller, Helen, Perkins, Neil D, Lakey, Jeremy H, Peters, Daniel T

“…Thermal regulation of gene expression occurs in many microorganisms, and is mediated via several typical mechanisms. Yersinia pestis is the causative agent of…”
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Integrating cell-signalling pathways with NF-κB and IKK function by Perkins, Neil D

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Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway by Perkins, Neil D

“…Numerous studies, published over many years, have established the key role that the IκB kinase (IKK) subunits, α and β, play in regulating the Nuclear Factor…”
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Regulation of Cyclin D1 RNA Stability by SNIP1 by BRACKEN, Cameron P, WALL, Steven J, BARRE, Benjamin, PANOV, Kostya I, AJUH, Paul M, PERKINS, Neil D

“…Cyclin D1 expression represents one of the key mitogen-regulated events during the G(1) phase of the cell cycle, whereas Cyclin D1 overexpression is frequently…”
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Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 by Sandhu, Sumit, Sou, Ieng F., Hunter, Jill E., Salmon, Lucy, Wilson, Caroline L., Perkins, Neil D., Hunter, Neil, Davies, Owen R., McClurg, Urszula L.

“…The synaptonemal complex (SC) is a supramolecular protein scaffold that mediates chromosome synapsis and facilitates crossing over during meiosis. In mammals,…”
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NFKB1: a suppressor of inflammation, ageing and cancer by Cartwright, Tyrell, Perkins, Neil D., L. Wilson, Caroline

“…The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in B‐cells (NF‐κB) pathway activation result from the combinatorial…”
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