Search Results - "Perkins, Louise M."

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy by Lohr, Jens G., Stojanov, Petar, Carter, Scott L., Cruz-Gordillo, Peter, Lawrence, Michael S., Auclair, Daniel, Sougnez, Carrie, Knoechel, Birgit, Gould, Joshua, Saksena, Gordon, Cibulskis, Kristian, McKenna, Aaron, Chapman, Michael A., Straussman, Ravid, Levy, Joan, Perkins, Louise M., Keats, Jonathan J., Schumacher, Steven E., Rosenberg, Mara, Anderson, Kenneth C., Richardson, Paul, Krishnan, Amrita, Lonial, Sagar, Kaufman, Jonathan, Siegel, David S., Vesole, David H., Roy, Vivek, Rivera, Candido E., Rajkumar, S. Vincent, Kumar, Shaji, Fonseca, Rafael, Ahmann, Greg J., Bergsagel, P. Leif, Stewart, A. Keith, Hofmeister, Craig C., Efebera, Yvonne A., Jagannath, Sundar, Chari, Ajai, Trudel, Suzanne, Reece, Donna, Wolf, Jeffrey, Martin, Thomas, Zimmerman, Todd, Rosenbaum, Cara, Jakubowiak, Andrzej J., Lebovic, Daniel, Vij, Ravi, Stockerl-Goldstein, Keith, Getz, Gad, Golub, Todd R.

“…We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes…”
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Initial genome sequencing and analysis of multiple myeloma by Chapman, Michael A., Lawrence, Michael S., Keats, Jonathan J., Cibulskis, Kristian, Sougnez, Carrie, Schinzel, Anna C., Harview, Christina L., Brunet, Jean-Philippe, Ahmann, Gregory J., Adli, Mazhar, Anderson, Kenneth C., Ardlie, Kristin G., Auclair, Daniel, Baker, Angela, Bergsagel, P. Leif, Bernstein, Bradley E., Drier, Yotam, Fonseca, Rafael, Gabriel, Stacey B., Hofmeister, Craig C., Jagannath, Sundar, Jakubowiak, Andrzej J., Krishnan, Amrita, Levy, Joan, Liefeld, Ted, Lonial, Sagar, Mahan, Scott, Mfuko, Bunmi, Monti, Stefano, Perkins, Louise M., Onofrio, Robb, Pugh, Trevor J., Rajkumar, S. Vincent, Ramos, Alex H., Siegel, David S., Sivachenko, Andrey, Stewart, A. Keith, Trudel, Suzanne, Vij, Ravi, Voet, Douglas, Winckler, Wendy, Zimmerman, Todd, Carpten, John, Trent, Jeff, Hahn, William C., Garraway, Levi A., Meyerson, Matthew, Lander, Eric S., Getz, Gad, Golub, Todd R.

“…Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38…”
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Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6 by Tiedemann, Rodger E., Zhu, Yuan Xiao, Schmidt, Jessica, Yin, Hongwei, Shi, Chang-Xin, Que, Qiang, Basu, Gargi, Azorsa, David, Perkins, Louise M., Braggio, Esteban, Fonseca, Rafael, Bergsagel, P. Leif, Mousses, Spyro, Stewart, A. Keith

“…A paucity of validated kinase targets in human multiple myeloma has delayed clinical deployment of kinase inhibitors in treatment strategies. We therefore…”
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One foundation's strategy to accelerate drug discovery through genomics by Perkins, Louise M, Young, Anne Quinn, Giusti, Kathy

“…The Multiple Myeloma Research Foundation (MMRF) has the principal goal of accelerating development of next-generation drugs for treating multiple myeloma. By…”
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Abstract B31: Strategic investments by the Melanoma Research Alliance in research and career development accelerate progress in melanoma prevention, diagnostics, and treatment by Mueller, Kristen L., Hurlbert, Marc, Perkins, Louise M.

“…Abstract Non-governmental entities, such as foundations, charities, philanthropists, and corporations, represent a growing source of research funding (1). The…”
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Abstract PL08-03: Melanoma Research Alliance: Investing in innovation by Perkins, Louise M.

“…Abstract Melanoma is the deadliest of all skin cancers with more than 132,000 new cases each year worldwide and rising incidence. In the United States alone,…”
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The three-dimensional solution structure of the SRC homology domain-2 of the growth factor receptor-bound protein-2 by Senior, M M, Frederick, A F, Black, S, Murgolo, N J, Perkins, L M, Wilson, O, Snow, M E, Wang, Y S

“…A set of high-resolution three-dimensional solution structures of the Src homology region-2 (SH2) domain of the growth factor receptor-bound protein-2 was…”
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The Multiple Myeloma Research Foundation (MMRF) CoMMpassSM Study: A Longitudinal Study in Newly-Diagnosed Multiple Myeloma Patients to Assess Genomic Profiles, Immunophenotypes and Clinical Outcomes by Needle, Michael N., Harrison, Beverly, Hoban, Carolyn, Kidd, Pamela G., Jewell, Scott, Monroe, Thomas, Keats, Jonathan J, Carpten, John, Perkins, Louise M., Anderson, Kenneth, Lonial, Sagar

“…Abstract 3980 The Multiple Myeloma Research Foundation (MMRF) CoMMpassSM trial plans to analyze the tumor genome from 1000 patients with newly-diagnosed active…”
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CpG Methylation Profiling in Multiple Myeloma by Salhia, Bodour, Baker, Angela, Keats, Jonathan J, Ahmann, Gregory, Auclair, Daniel, Mfuko, Bunmi, Perkins, Louise M., Levy, Joan, Bergsagel, Leif, Fonseca, Rafael, Carpten, John

“…Abstract 604 We have conducted a pilot study to interrogate both CpG hyper- and hypomethylation in Multiple Myeloma (MM) using the Illumina GoldenGate (GG)…”
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Kinome-Wide RNAi Studies in Human Multiple Myeloma Identify a Lymphoid Restricted Kinase GRK6 as a Selectively Vulnerable Target That Regulates STAT3/MCL1 by Tiedemann, Rodger E., Zhu, Yuan Xiao, Schmidt, Jessica, Yin, Hongwei, Que, Quick, Azorsa, David, Perkins, Louise M., Braggio, Esteban, Reeder, Craig B., Fonseca, Rafael, Bergsagel, P. Leif, Mousses, Spyro, Stewart, A. Keith

“…Abstract 601 A paucity of validated kinase targets in human multiple myeloma (MM) has delayed clinical deployment of kinase inhibitors in treatment strategies…”
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HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma by Chapman, Michael A, Brunet, Jean-Philippe, Keats, Jonathan J, Baker, Angela, Adli, Mazhar, Schinzel, Anna C., Ahmann, Gregory, Christina, Harview, Moore, Anna, Shanmugam, Vijayalakshmi, Perkins, Louise M., Auclair, Daniel, Hahn, William C., Bernstein, Bradley E., Bergsagel, Leif, Fonseca, Rafael, Carpten, John, Trent, Jeffrey, Golub, Todd R.

“…Abstract 832 We hypothesized that new therapeutic targets for multiple myeloma (MM) could be discovered through the integrative computational analysis of…”
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Interim Analyses of the MMRC Reference Collection Identifies Recurrent Genomic-Level Events in Multiple Myeloma and Demonstrates That CDKN2C/p18 Deletion Is the Pre-Eminent Copy Number Alteration in Poor Prognosis Disease by Chapman, Michael A, Brunet, Jean-Philippe, Baker, Angela, Keats, Jonathan, Ahmann, Gregory, Schinzel, Anna C, Moore, Anna, Shanmugam, Vijayalakshmi, Perkins, Louise M., Auclair, Daniel, Hahn, William C., Bergsagel, P. Leif, Fonseca, Rafael, Carpten, John, Trent, Jeffrey, Golub, Todd R.

“…The Multiple Myeloma Research Consortium (MMRC) Genomics Initiative was instigated to harness the power of multiple genomic approaches to further the…”
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The Multiple Myeloma Research Consortium Genomics Initiative by Trent, Jeffrey, Carpten, John, Reich, Michael, Liefeld, Ted, Keats, Jonathan, Mousses, Spyro, Hahn, William, Trudel, Suzanne, Siegel, David, Rajkumar, S. Vincent, Alsina, Melissa, Richardson, Paul, Anderson, Kenneth, Auclair, Daniel, Perkins, Louise M., Giusti, Kathy, Fonseca, Rafael, Golub, Todd R.

“…The Multiple Myeloma Research Consortium (MMRC) Genomics Initiative is a three-year program to analyze tumor tissue from hundreds of multiple myeloma (MM)…”
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Genomc-Wide Profiling of Gene Expression and DNA Copy Number Alterations in Multiple Myeloma by Keats, Jonathan, Chapman, Mike, Carpten, John, Chng, Wee-Joo, Baker, Angela, Ahmann, Gregory, Trudel, Suzanne, Siegel, David, Rajkumar, S. Vincent, Alsina, Melissa, Richardson, Paul, Anderson, Kenneth, Auclair, Daniel, Perkins, Louise M., Trent, Jeffrey, Golub, Todd R., Fonseca, Rafael

“…In an effort to identify novel genetic abnormalities in multiple myeloma (MM) we analyzed an initial set, as part of the Multiple Myeloma Research Consortium…”
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Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures by Georgiou, M, Perkins, L M, Payne, A H

“…Treatment of primary cultures of rat Leydig cells with 1 mM 8-bromo-cAMP for 2 days at ambient oxygen tension (19%) caused a 59% decrease in mitochondrial…”
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Activation of serum response element-regulated genes by lysophosphatidic acid by Perkins, Louise M., Ramirez, Fernando E., Kumar, Fernando E., Kumar, Chandra C., Thomson, Fiona J., Clark, Mike A.

“…Lysophosphatldic acid (LPA) is an important constituent of serum and shares its mitogenlc activity. Serum induction of several genes is regulated, at least in…”
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Chemical shift assignments and secondary structure of the Grb2 SH2 domain by heteronuclear NMR spectroscopy by Wang, Y S, Frederick, A F, Senior, M M, Lyons, B A, Black, S, Kirschmeier, P, Perkins, L M, Wilson, O

“…The growth factor receptor-bound protein-2 (Grb-2) is an adaptor protein that mediates signal transduction pathways. Chemical shift assignments were obtained…”
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Intratesticular site of aromatase activity and possible function of testicular estradiol by Payne, A H, Perkins, L M, Georgiou, M, Quinn, P G

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Sequence of the cDNA encoding Ras GTPase-activating protein from rat by Davis, M M, Catino, J J, Satoh, T, Kaziro, Y, Perkins, L M

“…We cloned and sequenced a 3296-bp cDNA encoding the rat Ras GTPase-activating protein (GAP). Comparison of the nucleotide (nt) and deduced amino acid (aa)…”
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Regulation of mitochondrial and microsomal cytochrome P-450 enzymes in Leydig cells by Payne, A H, Anakwe, O O, Hales, D B, Georgiou, M, Perkins, L M, Quinn, P G

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