Search Results - "Perkins, J"

The Inconsistency of “Optimal” Cutpoints Obtained using Two Criteria based on the Receiver Operating Characteristic Curve by Perkins, Neil J., Schisterman, Enrique F.

“…The use of biomarkers is of ever-increasing importance in clinical diagnosis of disease. In practice, a cutpoint is required for dichotomizing naturally…”
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cubical – fast radio interferometric calibration suite exploiting complex optimization by Kenyon, J S, Smirnov, O M, Grobler, T L, Perkins, S J

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Empirical Bayes single nucleotide variant-calling for next-generation sequencing data by Karimnezhad, Ali, Perkins, Theodore J.

“…One of the fundamental computational problems in cancer genomics is the identification of single nucleotide variants (SNVs) from DNA sequencing data. Many…”
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Multiple Imputation for Incomplete Data in Epidemiologic Studies by Harel, Ofer, Mitchell, Emily M, Perkins, Neil J, Cole, Stephen R, Tchetgen Tchetgen, Eric J, Sun, BaoLuo, Schisterman, Enrique F

“…Abstract Epidemiologic studies are frequently susceptible to missing information. Omitting observations with missing variables remains a common strategy in…”
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Identifying transcription factors with cell-type specific DNA binding signatures by Awdeh, Aseel, Turcotte, Marcel, Perkins, Theodore J

“…Transcription factors (TFs) bind to different parts of the genome in different types of cells, but it is usually assumed that the inherent DNA-binding…”
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Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment by Perkins, Edward J., Ashauer, Roman, Burgoon, Lyle, Conolly, Rory, Landesmann, Brigitte, Mackay, Cameron, Murphy, Cheryl A., Pollesch, Nathan, Wheeler, James R., Zupanic, Anze, Scholz, Stefan

“…An important goal in toxicology is the development of new ways to increase the speed, accuracy, and applicability of chemical hazard and risk assessment…”
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Chemical dispersants can suppress the activity of natural oil-degrading microorganisms by Kleindienst, Sara, Seidel, Michael, Ziervogel, Kai, Grim, Sharon, Loftis, Kathy, Harrison, Sarah, Malkin, Sairah Y., Perkins, Matthew J., Field, Jennifer, Sogin, Mitchell L., Dittmar, Thorsten, Passow, Uta, Medeiros, Patricia M., Joye, Samantha B.

“…During theDeepwater Horizonoil well blowout in the Gulf of Mexico, the application of 7 million liters of chemical dispersants aimed to stimulate microbial…”
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Strategies for cellular decision-making by Swain, Peter S, Perkins, Theodore J

“…Stochasticity pervades life at the cellular level. Cells receive stochastic signals, perform detection and transduction with stochastic biochemistry, and grow…”
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TF-3 Into The Lion’s Den: Fighting Sepsis Where it Lives Through Implementation of a Sepsis Outreach Project at a Local Skilled Nusing Facility by Perkins, J

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CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance by Rajaiah, Rajesh, Darren J. Perkins, Derek D. C. Ireland, Stefanie N. Vogel

“…Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) heterodimers is critical for both MyD88- and TIR-domain–containing…”
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TLR4/MyD88/PI3K interactions regulate TLR4 signaling by Laird, Michelle H. W., Rhee, Sang Hoon, Perkins, Darren J., Medvedev, Andrei E., Piao, Wenji, Fenton, Matthew J., Vogel, Stefanie N.

“…TLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host…”
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Topic choice contributes to the lower rate of NIH awards to African-American/black scientists by Hoppe, Travis A, Litovitz, Aviva, Willis, Kristine A, Meseroll, Rebecca A, Perkins, Matthew J, Hutchins, B Ian, Davis, Alison F, Lauer, Michael S, Valantine, Hannah A, Anderson, James M, Santangelo, George M

“…Despite efforts to promote diversity in the biomedical workforce, there remains a lower rate of funding of National Institutes of Health R01 applications…”
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Biomarkers of Delirium Duration and Delirium Severity in the ICU by Khan, Babar A, Perkins, Anthony J, Prasad, Nagendra K, Shekhar, Anantha, Campbell, Noll L, Gao, Sujuan, Wang, Sophia, Khan, Sikandar H, Marcantonio, Edward R, Twigg, Homer L, Boustani, Malaz A

“…OBJECTIVES:Both delirium duration and delirium severity are associated with adverse patient outcomes. Serum biomarkers associated with delirium duration and…”
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Ventral tegmental area astrocytes orchestrate avoidance and approach behavior by Gomez, J. A., Perkins, J. M., Beaudoin, G. M., Cook, N. B., Quraishi, S. A., Szoeke, E. A., Thangamani, K., Tschumi, C. W., Wanat, M. J., Maroof, A. M., Beckstead, M. J., Rosenberg, P. A., Paladini, C. A.

“…The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity…”
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Optimal Cut-Point and Its Corresponding Youden Index to Discriminate Individuals Using Pooled Blood Samples by Schisterman, Enrique F., Perkins, Neil J., Liu, Aiyi, Bondell, Howard

“…Costs can hamper the evaluation of the effectiveness of new biomarkers. Analysis of smaller numbers of pooled specimens has been shown to be a useful…”
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The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment by Brockmeier, Erica K, Hodges, Geoff, Hutchinson, Thomas H, Butler, Emma, Hecker, Markus, Tollefsen, Knut Erik, Garcia-Reyero, Natalia, Kille, Peter, Becker, Dörthe, Chipman, Kevin, Colbourne, John, Collette, Timothy W, Cossins, Andrew, Cronin, Mark, Graystock, Peter, Gutsell, Steve, Knapen, Dries, Katsiadaki, Ioanna, Lange, Anke, Marshall, Stuart, Owen, Stewart F, Perkins, Edward J, Plaistow, Stewart, Schroeder, Anthony, Taylor, Daisy, Viant, Mark, Ankley, Gerald, Falciani, Francesco

“…In conjunction with the second International Environmental Omics Symposium (iEOS) conference, held at the University of Liverpool (United Kingdom) in September…”
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Reorienting land degradation towards sustainable land management: Linking sustainable livelihoods with ecosystem services in rangeland systems by Reed, M.S., Stringer, L.C., Dougill, A.J., Perkins, J.S., Atlhopheng, J.R., Mulale, K., Favretto, N.

“…This paper identifies new ways of moving from land degradation towards sustainable land management through the development of economic mechanisms. It…”
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WACS: improving ChIP-seq peak calling by optimally weighting controls by Awdeh, Aseel, Turcotte, Marcel, Perkins, Theodore J

“…Chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq), initially introduced more than a decade ago, is widely used by the scientific…”
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Quantifying the mineral magnetic signature of petroleum systems and their source rocks: a study on the Inner Moray Firth, UK North Sea by Perkins, J R, Muxworthy, A R, Fraser, A J, Hu, P

“…SUMMARY This study aims to expand on existing connections between magnetic minerals and hydrocarbons within petroleum systems. Previous studies have focussed…”
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Mechanistic Description of Photochemical Oligomer Formation from Aqueous Pyruvic Acid by Rapf, Rebecca J, Perkins, Russell J, Carpenter, Barry K, Vaida, Veronica

“…The aqueous phase photochemistry of pyruvic acid, an important oxidation product of isoprene, is known to generate larger oligomeric species that may…”
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