Search Results - "Perkins, Diana O."

Potential Roles of Redox Dysregulation in the Development of Schizophrenia by Perkins, Diana O., Jeffries, Clark D., Do, Kim Q.

“…Converging evidence implicates redox dysregulation as a pathological mechanism driving the emergence of psychosis. Increased oxidative damage and decreased…”
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Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project by Perkins, Diana O, Jeffries, Clark D, Addington, Jean, Bearden, Carrie E, Cadenhead, Kristin S, Cannon, Tyrone D, Cornblatt, Barbara A, Mathalon, Daniel H, McGlashan, Thomas H, Seidman, Larry J, Tsuang, Ming T, Walker, Elaine F, Woods, Scott W, Heinssen, Robert

“…A barrier to preventative treatments for psychosis is the absence of accurate identification of persons at highest risk. A blood test that could substantially…”
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The Dark Side of the Moon: Meta-analytical Impact of Recruitment Strategies on Risk Enrichment in the Clinical High Risk State for Psychosis by Fusar-Poli, Paolo, Schultze-Lutter, Frauke, Cappucciati, Marco, Rutigliano, Grazia, Bonoldi, Ilaria, Stahl, Daniel, Borgwardt, Stephan, Riecher-Rössler, Anita, Addington, Jean, Perkins, Diana O, Woods, Scott W, McGlashan, Thomas, Lee, Jimmy, Klosterkötter, Joachim, Yung, Alison R, McGuire, Philip

“…The individual risk of developing psychosis after being tested for clinical high-risk (CHR) criteria (posttest risk of psychosis) depends on the underlying…”
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Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk by Perkins, Diana O, Olde Loohuis, Loes, Barbee, Jenna, Ford, John, Jeffries, Clark D, Addington, Jean, Bearden, Carrie E, Cadenhead, Kristin S, Cannon, Tyrone D, Cornblatt, Barbara A, Mathalon, Daniel H, McGlashan, Thomas H, Seidman, Larry J, Tsuang, Ming, Walker, Elaine F, Woods, Scott W

“…Objective:The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%−25%; improvements in risk prediction…”
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Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis by Perkins, Diana O., Gu, Hongbin, Boteva, Kalina, Lieberman, Jeffrey A.

“…OBJECTIVE: The duration of untreated psychosis may influence response to treatment, reflecting a potentially malleable progressive pathological process. The…”
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At Clinical High Risk for Psychosis: Outcome for Nonconverters by Addington, Jean, Cornblatt, Barbara A., Cadenhead, Kristin S., Cannon, Tyrone D., McGlashan, Thomas H., Perkins, Diana O., Seidman, Larry J., Tsuang, Ming T., Walker, Elaine F., Woods, Scott W., Heinssen, Robert

“…Objective:A major focus of early intervention research is determining the risk of conversion to psychosis and developing optimal algorithms of prediction…”
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North American Prodrome Longitudinal Study (NAPLS 2): Overview and recruitment by Addington, Jean, Cadenhead, Kristin S, Cornblatt, Barbara A, Mathalon, Daniel H, McGlashan, Thomas H, Perkins, Diana O, Seidman, Larry J, Tsuang, Ming T, Walker, Elaine F, Woods, Scott W, Addington, Jack A, Cannon, Tyrone D

“…Abstract The North American Prodrome Longitudinal Study (NAPLS) is a consortium of eight programs focusing on the psychosis prodrome. Funded by the National…”
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Nuclear and cytoplasmic localization of neural stem cell microRNAs by Jeffries, Clark D, Fried, Howard M, Perkins, Diana O

“…Although generally regarded as functional in the cytoplasm, a number of microRNAs (miRNAs) have been found in the nucleus, possibly with a role in gene…”
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Cortisol Levels and Risk for Psychosis: Initial Findings from the North American Prodrome Longitudinal Study by Walker, Elaine F, Trotman, Hanan D, Pearce, Brad D, Addington, Jean, Cadenhead, Kristin S, Cornblatt, Barbara A, Heinssen, Robert, Mathalon, Daniel H, Perkins, Diana O, Seidman, Larry J, Tsuang, Ming T, Cannon, Tyrone D, McGlashan, Thomas H, Woods, Scott W

“…Background Studies of biomarkers of hypothalamic-pituitary-adrenal activity indicate that psychotic disorders are associated with elevated cortisol. This study…”
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Negative symptoms in individuals at clinical high risk of psychosis by Piskulic, Danijela, Addington, Jean, Cadenhead, Kristin S, Cannon, Tyrone D, Cornblatt, Barbara A, Heinssen, Robert, Perkins, Diana O, Seidman, Larry J, Tsuang, Ming T, Walker, Elaine F, Woods, Scott W, McGlashan, Thomas H

“…Abstract Negative symptoms are present in the psychosis prodrome. However, the extent to which these symptoms are present prior to the onset of the first…”
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Validity of the Prodromal Risk Syndrome for First Psychosis: Findings From the North American Prodrome Longitudinal Study by Woods, Scott W., Addington, Jean, Cadenhead, Kristin S., Cannon, Tyrone D., Cornblatt, Barbara A., Heinssen, Robert, Perkins, Diana O., Seidman, Larry J., Tsuang, Ming T., Walker, Elaine F., McGlashan, Thomas H.

“…Treatment and prevention studies over the past decade have enrolled patients believed to be at risk for future psychosis. These patients were considered at…”
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Social functioning in individuals at clinical high risk for psychosis by Addington, Jean, Penn, David, Woods, Scott W, Addington, Donald, Perkins, Diana O

“…Abstract Poor social functioning is a hallmark of schizophrenia. The purpose of this study was to examine social functioning in individuals at clinical high…”
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A Randomized Trial Examining the Effectiveness of Switching From Olanzapine, Quetiapine, or Risperidone to Aripiprazole to Reduce Metabolic Risk: Comparison of Antipsychotics for Metabolic Problems (CAMP) by Stroup, T. Scott, McEvoy, Joseph P., Ring, Kimberly D., Hamer, Robert H., LaVange, Lisa M., Swartz, Marvin S., Rosenheck, Robert A., Perkins, Diana O., Nussbaum, Abraham M., Lieberman, Jeffrey A.

“…Patients with a BMI of 27 or higher and a non-HDL cholesterol level of 130 mg/dl or higher on stable doses of olanzapine, quetiapine, or risperidone were…”
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Efficacy and Tolerability of Olanzapine, Quetiapine, and Risperidone in the Treatment of Early Psychosis: A Randomized, Double-Blind 52-Week Comparison by McEvoy, Joseph P., Lieberman, Jeffrey A., Perkins, Diana O., Hamer, Robert M., Gu, Hongbin, Lazarus, Arthur, Sweitzer, Dennis, Olexy, Christina, Weiden, Peter, Strakowski, Stephen D.

“…Objective: This 52-week randomized, double-blind, flexible-dose, multicenter study evaluated the overall effectiveness (as measured by treatment…”
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Social decline in the psychosis prodrome: Predictor potential and heterogeneity of outcome by Carrión, Ricardo E., Auther, Andrea M., McLaughlin, Danielle, Addington, Jean, Bearden, Carrie E., Cadenhead, Kristin S., Cannon, Tyrone D., Keshavan, Matcheri, Mathalon, Daniel H., McGlashan, Thomas H., Perkins, Diana O., Seidman, Larry, Stone, William, Tsuang, Ming, Walker, Elaine F., Woods, Scott W., Torous, John, Cornblatt, Barbara A.

“…While an established clinical outcome of high importance, social functioning has been emerging as possibly having a broader significance to the evolution of…”
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Premorbid functional development and conversion to psychosis in clinical high-risk youths by Tarbox, Sarah I, Addington, Jean, Cadenhead, Kristin S, Cannon, Tyrone D, Cornblatt, Barbara A, Perkins, Diana O, Seidman, Larry J, Tsuang, Ming T, Walker, Elaine F, Heinssen, Robert, McGlashan, Thomas H, Woods, Scott W

“…Deterioration in premorbid functioning is a common feature of schizophrenia, but sensitivity to psychosis conversion among clinical high-risk samples has not…”
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A greedy regression algorithm with coarse weights offers novel advantages by Jeffries, Clark D., Ford, John R., Tilson, Jeffrey L., Perkins, Diana O., Bost, Darius M., Filer, Dayne L., Wilhelmsen, Kirk C.

“…Regularized regression analysis is a mature analytic approach to identify weighted sums of variables predicting outcomes. We present a novel Coarse…”
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Effects of Olanzapine, Quetiapine, and Risperidone on Neurocognitive Function in Early Psychosis: A Randomized, Double-Blind 52-Week Comparison by Keefe, Richard S.E., Sweeney, John A., Gu, Hongbin, Hamer, Robert M., Perkins, Diana O., McEvoy, Joseph P., Lieberman, Jeffrey A.

“…Objective: The authors sought to compare the effects of olanzapine, quetiapine, and risperidone on neurocognitive function in patients with early psychosis…”
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A longitudinal study of neurocognitive function in individuals at-risk for psychosis by Keefe, Richard S.E., Perkins, Diana O., Gu, Hongbin, Zipursky, Robert B., Christensen, Bruce K., Lieberman, Jeffery A.

“…Clinically defined prodromal diagnostic criteria identify at-risk individuals with a 35–40% likelihood of developing a psychotic disorder within a year. The…”
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Implications for the Neural Basis of Social Cognition for the Study of Schizophrenia by Pinkham, Amy E., Penn, David L., Perkins, Diana O., Lieberman, Jeffrey

“…OBJECTIVE: The study of social cognition in schizophrenia has received growing attention in recent years. At the same time, a large body of work has explored…”
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