Search Results - "Perkins, Darren J"

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance by Rajaiah, Rajesh, Darren J. Perkins, Derek D. C. Ireland, Stefanie N. Vogel

“…Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) heterodimers is critical for both MyD88- and TIR-domain–containing…”
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cAMP levels regulate macrophage alternative activation marker expression by Polumuri, Swamy, Perkins, Darren J, Vogel, Stefanie N

“…The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant…”
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Microbiota-Derived Metabolites, Indole-3-aldehyde and Indole-3-acetic Acid, Differentially Modulate Innate Cytokines and Stromal Remodeling Processes Associated with Autoimmune Arthritis by Langan, David, Perkins, Darren J, Vogel, Stefanie N, Moudgil, Kamal D

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints. Inflammation, new blood vessel formation…”
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5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential by Prantner, Daniel, Perkins, Darren J., Lai, Wendy, Williams, Mark S., Sharma, Shruti, Fitzgerald, Katherine A., Vogel, Stefanie N.

“…The chemotherapeutic agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a potent inducer of type I IFNs and other cytokines. This ability is essential for…”
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TLR4/MyD88/PI3K interactions regulate TLR4 signaling by Laird, Michelle H. W., Rhee, Sang Hoon, Perkins, Darren J., Medvedev, Andrei E., Piao, Wenji, Fenton, Matthew J., Vogel, Stefanie N.

“…TLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host…”
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Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs) by Perkins, Darren J., Vogel, Stefanie N.

“…The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments…”
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Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection by Shirey, Kari Ann, Perkins, Darren J, Lai, Wendy, Zhang, Wei, Fernando, Lurds R, Gusovsky, Fabian, Blanco, Jorge C G, Vogel, Stefanie N

“…We previously reported that the Toll-like receptor 4 (TLR4) antagonist Eritoran blocks acute lung injury (ALI) therapeutically in mouse and cotton rat models…”
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Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists by Polumuri, Swamy Kumar, Jayakar, Gift Gunaraj, Shirey, Kari Ann, Roberts, Zachary J, Perkins, Darren J, Pitha, Paula M, Vogel, Stefanie N

“…IL-33, a member of the IL-1 family of cytokines, is produced by many cell types, including macrophages, yet its regulation is largely unknown. Treatment of…”
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Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively by Perkins, Darren J, Rajaiah, Rajesh, Tennant, Sharon M, Ramachandran, Girish, Higginson, Ellen E, Dyson, Tristan N, Vogel, Stefanie N

“…Innate immune inflammatory responses are subject to complex layers of negative regulation at intestinal mucosal surfaces. Although the type I IFN system is…”
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M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice by Vlk, Alexandra M, Prantner, Daniel, Shirey, Kari Ann, Perkins, Darren J, Buzza, Marguerite S, Thumbigere-Math, Vivek, Keegan, Achsah D, Vogel, Stefanie N

“…Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, impacts millions of individuals worldwide and severely impairs the quality…”
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Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages by Rajaiah, Rajesh, Perkins, Darren J, Polumuri, Swamy Kumar, Zhao, Aiping, Keegan, Achsah D, Vogel, Stefanie N

“…Endotoxin tolerance is a complex phenomenon characterized primarily by decreased production of proinflammatory cytokines, chemokines, and other inflammatory…”
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Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages by Ramachandran, Girish, Perkins, Darren J, Schmidlein, Patrick J, Tulapurkar, Mohan E, Tennant, Sharon M

“…Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype…”
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The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation by Wang, Xiaowei, Shaw, Dana K, Sakhon, Olivia S, Snyder, Greg A, Sundberg, Eric J, Santambrogio, Laura, Sutterwala, Fayyaz S, Dumler, J Stephen, Shirey, Kari Ann, Perkins, Darren J, Richard, Katharina, Chagas, Andrezza C, Calvo, Eric, Kopecký, Jan, Kotsyfakis, Michail, Pedra, Joao H F

“…Tick saliva contains a number of effector molecules that inhibit host immunity and facilitate pathogen transmission. How tick proteins regulate immune…”
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The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation by Wang, Xiaowei, Shaw, Dana K, Hammond, Holly L, Sutterwala, Fayyaz S, Rayamajhi, Manira, Shirey, Kari Ann, Perkins, Darren J, Bonventre, Joseph V, Velayutham, Thangam S, Evans, Sean M, Rodino, Kyle G, VieBrock, Lauren, Scanlon, Karen M, Carbonetti, Nicholas H, Carlyon, Jason A, Miao, Edward A, McBride, Jere W, Kotsyfakis, Michail, Pedra, Joao H F

“…Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular…”
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Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production by Perkins, Darren J, Polumuri, Swamy K, Pennini, Meghan E, Lai, Wendy, Xie, Ping, Vogel, Stefanie N

“…The cell surface/endosomal Toll-like Receptors (TLRs) are instrumental in initiating immune responses to both bacteria and viruses. With the exception of TLR2,…”
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AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling by Prantner, Daniel, Perkins, Darren J., Vogel, Stefanie N.

“…The host protein Stimulator of Interferon Genes (STING) has been shown to be essential for recognition of both viral and intracellular bacterial pathogens, but…”
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ER-transiting bacterial toxins amplify STING innate immune responses and elicit ER stress by Schlenker, Catherine, Richard, Katharina, Skobelkina, Sofia, Mathena, R Paige, Perkins, Darren J

“…The cGAS/STING sensor system drives innate immune responses to intracellular microbial double-stranded DNA (dsDNA) and bacterial cyclic nucleotide second…”
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Autocrine-paracrine prostaglandin E 2 signaling restricts TLR4 internalization and TRIF signaling by Perkins, Darren J, Richard, Katharina, Hansen, Anne-Marie, Lai, Wendy, Nallar, Shreeram, Koller, Beverly, Vogel, Stefanie N

“…The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal-transduction cascades: a signal dependent on the adaptors TIRAP (Mal)…”
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A Toll-like receptor-responsive kinase, protein kinase R, is inactivated in endotoxin tolerance through differential K63/K48 ubiquitination by Perkins, Darren J, Qureshi, Nilofer, Vogel, Stefanie N

“…Overwhelming inflammation triggered by systemic infection in bacterial sepsis contributes to the pathology of this condition. Toll-like receptors (TLRs) are…”
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Defects in Translational Regulation Mediated by the α Subunit of Eukaryotic Initiation Factor 2 Inhibit Antiviral Activity and Facilitate the Malignant Transformation of Human Fibroblasts by Perkins, Darren J., Barber, Glen N.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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