Search Results - "Perkel, David J"

The role of ultrasonic vocalizations in mouse communication by Portfors, Christine V, Perkel, David J

“…Highlights • Mice do not show evidence of imitative vocal learning. • The lack of vocal learning makes the mouse an excellent model system for understanding…”
Get full text

Robo3-Driven Axon Midline Crossing Conditions Functional Maturation of a Large Commissural Synapse by Michalski, Nicolas, Babai, Norbert, Renier, Nicolas, Perkel, David J., Chédotal, Alain, Schneggenburger, Ralf

“…During the formation of neuronal circuits, axon pathfinding decisions specify the location of synapses on the correct brain side and in correct target areas…”
Get full text

A Basal Ganglia Pathway Drives Selective Auditory Responses in Songbird Dopaminergic Neurons via Disinhibition by Gale, Samuel D, Perkel, David J

“…Dopaminergic neurons in mammals respond to rewards and reward-predicting cues, and are thought to play an important role in learning actions or sensory cues…”
Get full text

Dopaminergic modulation of basal ganglia output through coupled excitation–inhibition by Budzillo, Agata, Duffy, Alison, Miller, Kimberly E., Fairhall, Adrienne L., Perkel, David J.

“…Learning and maintenance of skilled movements require exploration of motor space and selection of appropriate actions. Vocal learning and social…”
Get full text

Premotor synaptic plasticity limited to the critical period for song learning by Sizemore, Max, Perkel, David J

“…Synaptic plasticity has been hypothesized to underlie learning and memory. Understanding of how such plasticity might produce motor learning is limited, in…”
Get full text

Organization of the songbird basal ganglia, including area X by Person, Abigail L., Gale, Samuel D., Farries, Michael A., Perkel, David J.

“…Area X is a songbird basal ganglia nucleus that is required for vocal learning. Both Area X and its immediate surround, the medial striatum (MSt), contain…”
Get full text

Revised nomenclature for avian telencephalon and some related brainstem nuclei by Reiner, Anton, Perkel, David J., Bruce, Laura L., Butler, Ann B., Csillag, András, Kuenzel, Wayne, Medina, Loreta, Paxinos, George, Shimizu, Toru, Striedter, Georg, Wild, Martin, Ball, Gregory F., Durand, Sarah, Gütürkün, Onur, Lee, Diane W., Mello, Claudio V., Powers, Alice, White, Stephanie A., Hough, Gerald, Kubikova, Lubica, Smulders, Tom V., Wada, Kazuhiro, Dugas‐Ford, Jennifer, Husband, Scott, Yamamoto, Keiko, Yu, Jing, Siang, Connie, Jarvis, Erich D.

“…The standard nomenclature that has been used for many telencephalic and related brainstem structures in birds is based on flawed assumptions of homology to…”
Get full text

Steroid Hormones Act Transsynaptically within the Forebrain to Regulate Neuronal Phenotype and Song Stereotypy by Meitzen, John, Moore, Ignacio T, Lent, Karin, Brenowitz, Eliot A, Perkel, David J

“…Steroid sex hormones induce dramatic seasonal changes in reproductive related behaviors and their underlying neural substrates in seasonally breeding…”
Get full text

Dopaminergic Input to the Inferior Colliculus in Mice by Nevue, Alexander A, Elde, Cameron J, Perkel, David J, Portfors, Christine V

“…The response of sensory neurons to stimuli can be modulated by a variety of factors including attention, emotion, behavioral context, and disorders involving…”
Get full text

A daily oscillation in the fundamental frequency and amplitude of harmonic syllables of zebra finch song by Wood, William E, Osseward, 2nd, Peter J, Roseberry, Thomas K, Perkel, David J

“…Complex motor skills are more difficult to perform at certain points in the day (for example, shortly after waking), but the daily trajectory of motor-skill…”
Get full text

Pallidal Neuron Activity Increases during Sensory Relay through Thalamus in a Songbird Circuit Essential for Learning by Person, Abigail L, Perkel, David J

“…Disinhibition of the thalamus remains the primary model of information transfer between the basal ganglia and the cortex. Yet in apparent conflict with this…”
Get full text

Physiological Properties of Zebra Finch Ventral Tegmental Area and Substantia Nigra Pars Compacta Neurons by Gale, Samuel D, Perkel, David J

“…1 Graduate Program in Neurobiology and Behavior and 2 Departments of Biology and Otolaryngology, University of Washington, Seattle, Washington Submitted 3…”
Get full text

Postsynaptic neural activity regulates neuronal addition in the adult avian song control system by Larson, Tracy A., Wang, Tsu-Wei, Gale, Samuel D., Miller, Kimberly E., Thatra, Nivretta M., Caras, Melissa L., Perkel, David J., Brenowitz, Eliot A.

“…A striking feature of the nervous system is that it shows extensive plasticity of structure and function that allows animals to adjust to changes in their…”
Get full text

Seasonal changes in patterns of gene expression in avian song control brain regions by Thompson, Christopher K, Meitzen, John, Replogle, Kirstin, Drnevich, Jenny, Lent, Karin L, Wissman, Anne Marie, Farin, Federico M, Bammler, Theo K, Beyer, Richard P, Clayton, David F, Perkel, David J, Brenowitz, Eliot A

“…Photoperiod and hormonal cues drive dramatic seasonal changes in structure and function of the avian song control system. Little is known, however, about the…”
Get full text

A novel basal ganglia pathway forms a loop linking a vocal learning circuit with its dopaminergic input by Gale, Samuel D., Person, Abigail L., Perkel, David J.

“…Dopamine has been implicated in mediating contextual modulation of motor behaviors and learning in many species. In songbirds, dopamine may act on the basal…”
Get full text

Unitary IPSPs Drive Precise Thalamic Spiking in a Circuit Required for Learning by Person, Abigail L., Perkel, David J.

“…Song learning in birds requires a basal ganglia-thalamo-pallial loop that contains a calyceal GABAergic synapse in the thalamus. Information processing within…”
Get full text

Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning by Thompson, John A, Perkel, David J

“…Activation of type 1 cannabinoid receptors (CB(1)R) in many central nervous system structures induces both short- and long-term changes in synaptic…”
Get full text

Adult neurogenesis is necessary for functional regeneration of a forebrain neural circuit by Brenowitz, Eliot A, Lent, Karin L, Miller, Kimberly E, Perkel, David J

“…In adult songbirds, new neurons are born in large numbers in the proliferative ventricular zone in the telencephalon and migrate to the adjacent song control…”
Get full text

Differential development of myelin in zebra finch song nuclei by Champoux, Katharine L., Miller, Kimberly E., Perkel, David J.

“…Songbirds learn vocalizations by hearing and practicing songs. As song develops, the tempo becomes faster and more precise. In the songbird brain, discrete…”
Get full text

Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song by Duffy, Alison, Abe, Elliott, Perkel, David J., Fairhall, Adrienne L.

“…Performing a stereotyped behavior successfully over time requires both maintaining performance quality and adapting efficiently to environmental or physical…”
Get full text