Search Results - "Perk, Lars R"

Immuno‐PET: A Navigator in Monoclonal Antibody Development and Applications by van Dongen, Guus A.M.S., Visser, Gerard W.M., Lub‐de Hooge, Marjolijn N., de Vries, Elisabeth G., Perk, Lars R.

“…Learning Objectives After completing this course, the reader will be able to: Discuss the technical advances that have led to recent rapid developments in…”
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Optimised GMP-compliant production of [18F]DPA-714 on the Trasis AllinOne module by Cybulska, Klaudia A., Bloemers, Vera, Perk, Lars R., Laverman, Peter

“…Background The translocator protein 18 kDa is recognised as an important biomarker for neuroinflammation due to its soaring expression in microglia. This…”
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11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain by Funke, Uta, Vugts, Danielle J., Janssen, Bieneke, Spaans, Arnold, Kruijer, Perry S., Lammertsma, Adriaan A., Perk, Lars R., Windhorst, Albert D.

“…The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an…”
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Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p -isothiocyanatobenzyl-desferrioxamine by van Dongen, Guus A M S, Vosjan, Maria J W D, Perk, Lars R, Visser, Gerard W M, Budde, Marianne, Jurek, Paul, Kiefer, Garry E

“…The positron emitter zirconium-89 ( 89 Zr) has very attractive properties for positron emission tomography (PET) imaging of intact monoclonal antibodies (mAbs)…”
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p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging by Perk, Lars R., Vosjan, Maria J. W. D., Visser, Gerard W. M., Budde, Marianne, Jurek, Paul, Kiefer, Garry E., van Dongen, Guus A. M. S.

“…Purpose Immuno-PET is an emerging imaging tool for the selection of high potential antibodies (mAbs) for imaging and therapy. The positron emitter zirconium-89…”
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In Vivo VEGF Imaging with Radiolabeled Bevacizumab in a Human Ovarian Tumor Xenograft by Nagengast, Wouter B, de Vries, Elisabeth G, Hospers, Geke A, Mulder, Nanno H, de Jong, Johan R, Hollema, Harry, Brouwers, Adrienne H, van Dongen, Guus A, Perk, Lars R, Lub-de Hooge, Marjolijn N

“…Vascular endothelial growth factor (VEGF), released by tumor cells, is an important growth factor in tumor angiogenesis. The humanized monoclonal antibody…”
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Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation by Janssen, Bieneke, Vugts, Danielle J., Funke, Uta, Spaans, Arnold, Schuit, Robert C., Kooijman, Esther, Rongen, Marissa, Perk, Lars R., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated…”
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(89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab by Perk, Lars R, Visser, Gerard W M, Vosjan, Maria J W D, Stigter-van Walsum, Marijke, Tijink, Bernard M, Leemans, C René, van Dongen, Guus A M S

“…Immuno-PET as a scouting procedure before radioimmunotherapy (RIT) aims at confirming tumor targeting and accurately estimating radiation dose delivery to both…”
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(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy by Tijink, Bernard M, Perk, Lars R, Budde, Marianne, Stigter-van Walsum, Marijke, Visser, Gerard W M, Kloet, Reina W, Dinkelborg, Ludger M, Leemans, C René, Neri, Dario, van Dongen, Guus A M S

“…The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical…”
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Preparation and evaluation of (89)Zr-Zevalin for monitoring of (90)Y-Zevalin biodistribution with positron emission tomography by Perk, Lars R, Visser, Otto J, Stigter-van Walsum, M, Vosjan, Maria J W D, Visser, Gerard W M, Zijlstra, Josée M, Huijgens, Peter C, van Dongen, Guus A M S

“…To evaluate whether (89)Zr can be used as a PET surrogate label for quantification of (90)Y-ibritumomab tiuxetan ((90)Y-Zevalin) biodistribution and dosimetry…”
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(11) C-labeled and (18) F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain by Funke, Uta, Vugts, Danielle J, Janssen, Bieneke, Spaans, Arnold, Kruijer, Perry S, Lammertsma, Adriaan A, Perk, Lars R, Windhorst, Albert D

“…The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an…”
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Technical Note: Building a combined cyclotron and MRI facility: Implications for interference by Hofman, Mark B. M., Kuijer, Joost P. A., de Ridder, Jan Willem, Perk, Lars R., Verdaasdonk, Rudolf M.

“…Purpose: With the introduction of hybrid PET/MRI systems, it has become more likely that the cyclotron and MRI systems will be located close to each other…”
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Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET by Vosjan, Maria J. W. D., Perk, Lars R., Roovers, Rob C., Visser, Gerard W. M., Stigter-van Walsum, Marijke, van Bergen en Henegouwen, Paul M. P., van Dongen, Guus A. M. S.

“…Purpose The ∼15 kDa variable domains of camelid heavy-chain-only antibodies (called Nanobodies®) have the flexibility to be formatted as monovalent,…”
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Development and Characterization of Clinical-Grade 89Zr-Trastuzumab for HER2/neu ImmunoPET Imaging by Dijkers, Eli C.F, Kosterink, Jos G.W, Rademaker, Anna P, Perk, Lars R, van Dongen, Guus A.M.S, Bart, Joost, de Jong, Johan R, de Vries, Elisabeth G.E, Lub-de Hooge, Marjolijn N

“…The anti-human epidermal growth factor receptor 2 (HER2/neu) antibody trastuzumab is administered to patients with HER2/neu-overexpressing breast cancer…”
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124I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of 131I-L19-SIP radioimmunotherapy by Tijink, Bernard M., Perk, Lars R., Budde, Marianne, Stigter-van Walsum, Marijke, Visser, Gerard W. M., Kloet, Reina W., Dinkelborg, Ludger M., Leemans, C. René, Neri, Dario, van Dongen, Guus A. M. S.

“…Purpose The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A…”
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Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30 by Perk, Lars R., Stigter-van Walsum, Marijke, Visser, Gerard W. M., Kloet, Reina W., Vosjan, Maria J. W. D., Leemans, C. René, Giaccone, Giuseppe, Albano, Raffaella, Comoglio, Paolo M., van Dongen, Guus A. M. S.

“…Purpose Targeting the c-Met receptor with monoclonal antibodies (MAbs) is an appealing approach for cancer diagnosis and treatment because this receptor plays…”
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Radioimmunotherapy for indolent B-cell non-Hodgkin lymphoma in relapsed, refractory and transformed disease by Visser, Otto J, Perk, Lars R, Zijlstra, Josée M, van Dongen, Guus A M S, Huijgens, Peter C, van de Loosdrecht, Arjan A

“…Radioimmunotherapy (RIT) is a new treatment modality that combines the benefits of radiotherapy and immunotherapy. In RIT, a radionuclide is coupled to a…”
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Abstract 5275: Conjugation and radiolabeling of monoclonal antibodies and other proteins with 89Zr or 68Ga for PET imaging using p-isothiocyanatobenzyl-desferrioxamine by Vosjan, Maria Jwd, Perk, Lars R., Visser, Gerard Wm, Jurek, Paul, Kiefer, Garry E., van Dongen, Guus Ams

“…Presently, hundreds of intact monoclonal antibodies (mAbs) and mAb fragments are under clinical development because of their excellent potential treatment of…”
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Synthesis and initial preclinical evaluation of the P2X 7 receptor antagonist [ 11 C]A‐740003 as a novel tracer of neuroinflammation by Janssen, Bieneke, Vugts, Danielle J., Funke, Uta, Spaans, Arnold, Schuit, Robert C., Kooijman, Esther, Rongen, Marissa, Perk, Lars R., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated…”
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Facile labelling of an anti-epidermal growth factor receptor Nanobody with super(68)Ga via a novel bifunctional desferal chelate for immuno-PET by Vosjan, Maria JWD, Perk, Lars R, Roovers, Rob C, Visser, Gerard WM, Stigter-van Walsum, Marijke, Bergen en Henegouwen, Paul MP, Dongen, Guus AMS

“…Purpose: The 15 kDa variable domains of camelid heavy-chain-only antibodies (called Nanobodies registered ) have the flexibility to be formatted as monovalent,…”
Get full text