Long-Term Experience with Balloon Dilation for Short Bulbar and Membranous Urethral Strictures: Establishing a Baseline in the Active Drug Treatment Era

Long-Term Experience with Balloon Dilation for Short Bulbar and Membranous Urethral Strictures: Establishing a Baseline in the Active Drug Treatment Era

Transurethral balloon dilation (BD) is a minimally invasive treatment for urethral stricture disease (USD) performed primarily or as a recurrence salvage maneuver. With the introduction of drug-coated balloons, we sought to characterize patient outcomes using non-medicated balloons. A retrospective...

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Bibliographic Details
Published in:Journal of clinical medicine Vol. 11; no. 11; p. 3095
Main Authors: Beeder, Lauren A, Cook, Grayden S, Nealon, Samantha W, Badkhshan, Shervin, Sanders, Sarah C, Perito, Dylan P, Hudak, Steven J, Morey, Allen F
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 30-05-2022
MDPI
Subjects:
Catheters
Clinical medicine
Endoscopy
Failure
Medical referrals
Patients
Radiation therapy
Surgeons
Urinary retention
Urinary tract infections
Urogenital system
Urology
United States > US
balloon dilation
success rate
urethral stricture
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Summary:Transurethral balloon dilation (BD) is a minimally invasive treatment for urethral stricture disease (USD) performed primarily or as a recurrence salvage maneuver. With the introduction of drug-coated balloons, we sought to characterize patient outcomes using non-medicated balloons. A retrospective review identified patients who underwent BD from 2007 to 2021. Patient and stricture characteristics were collected. All dilations employed the 24Fr UroMax system. Clinical failure was defined by patient-reported lower urinary tract symptom recurrence or need for further stricture management. Ninety-one patients underwent BD with follow-up median (IQR) 12 (3-40) months. Most (75/91, 82%) had prior treatment for USD (endoscopic 50/91 (55%), 51/91 (56%) urethroplasty) before BD. Recurrence rates did not significantly differ between treatment-naïve and salvage patients (44% vs. 52% ( = 0.55)). Median (IQR) time to failure was 6 (3-13) months. The most common complications were urinary tract infection (8%) and post-operative urinary retention requiring catheterization (3%). Radiation history was noted in 33/91 (36%) with 45% recurrence. Patients without previous radiation had a similar recurrence rate of 52% ( = 0.88). Balloon dilation had minimal complications and overall, 50% recurrence rate, consistent regardless of stricture characteristics, radiation history, or prior treatments. These results represent an important clinical benchmark for comparing outcomes using drug-coated balloons.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11113095