Search Results - "Perissutti, B"

Evaluation of solid carvedilol-loaded SMEDDS produced by the spray drying method and a study of related substances by Mandić, J., Kosmač, I., Kovačević, M., Hodnik, B., Hodnik, Ž., Vrečer, F., Gašperlin, M., Perissutti, B., Zvonar Pobirk, A.

“…[Display omitted] •Spray drying enables production of s-SMEDDS with high SMEDDS loading (up to 67% w/w).•Mixing time of dispersion before spray drying has…”
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Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation by Franceschinis, E., Santomaso, A.C., Benda, L., Perissutti, B., Voinovich, D., Realdon, N.

“…Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems. The…”
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Solid state mechanochemical activation of Silybum marianum dry extract with betacyclodextrins: Characterization and bioavailability of the coground systems by Voinovich, D, Perissutti, B, Grassi, M, Passerini, N, Bigotto, A

“…Silybum marianum dry extract, whose therapeutic use is partially restricted by the insolubility in water of its main flavonolignans, was subjected to a…”
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Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery by Martinac, A., Filipović-Grčić, J., Voinovich, D., Perissutti, B., Franceschinis, E.

“…Loratadine-loaded microspheres were prepared by spray-drying of dispersions, emulsions and suspensions differing in polymeric composition and solvents used…”
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Immunomodulation mediated by a herbal syrup containing a standardized Echinacea root extract: A pilot study in healthy human subjects on cytokine gene expression by Dapas, B., Dall’Acqua, S., Bulla, R., Agostinis, C., Perissutti, B., Invernizzi, S., Grassi, G., Voinovich, D.

“…In this study, the immunomodulatory effect of a triply standardized Echinacea angustifolia root extract (Polinacea®) was evaluated in 10 healthy subjects. Ten…”
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A new approach to enhance oral bioavailability of Silybum Marianum dry extract: Association of mechanochemical activation and spray congealing by Passerini, N., Perissutti, B., Albertini, B., Franceschinis, E., Lenaz, D., Hasa, D., Locatelli, I., Voinovich, D.

“…The combination of mechanochemical activation and spray congealing produces a delivery system with enhanced oral bioavailability of main flavolignans of…”
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Quality improvement of melt extruded laminar systems using mixture design by Hasa, D., Perissutti, B., Campisi, B., Grassi, M., Grabnar, I., Golob, S., Mian, M., Voinovich, D.

“…[Display omitted] This study investigates the application of melt extrusion for the development of an oral retard formulation with a precise drug release over…”
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Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets by Iosio, T., Voinovich, D., Perissutti, B., Serdoz, F., Hasa, D., Grabnar, I., Acqua, S. Dall’, Zara, G.P., Muntoni, E., Pinto, J.F.

“…The objective of this study was to develop new solid self-emulsifying pellets to deliver milk thistle extract (silymarin). These pellets were prepared via…”
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Processing of carbamazepine–PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution by Moneghini, M., Kikic, I., Voinovich, D., Perissutti, B., Filipović-Grčić, J.

“…The purpose of this study was to apply the attractive technique of the supercritical fluid to the preparation of solvent-free solid dispersions. In particular,…”
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Self-emulsifying pellets in a lab-scale high shear mixer: Formulation and production design by Franceschinis, E., Bortoletto, C., Perissutti, B., Dal Zotto, M., Voinovich, D., Realdon, N.

“…In this investigation, the preparation of solid self-emulsifying drug delivery systems (solid-SEDDS) by means of a wet granulation process was optimized in a…”
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Preparation of sustained release co-extrudates by hot-melt extrusion and mathematical modelling of in vitro/ in vivo drug release profiles by Quintavalle, U., Voinovich, D., Perissutti, B., Serdoz, F., Grassi, G., Dal Col, A., Grassi, M.

“…Aim of this work was to develop a cylindrical co-extrudate characterised by an in vivo sustained release profile by means of a hot-melt extrusion process…”
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Pharmacokinetics and immunomodulatory effects of phytotherapeutic lozenges (bonbons) with Echinacea purpurea extract by Guiotto, P., Woelkart, K., Grabnar, I., Voinovich, D., Perissutti, B., Invernizzi, S., Granzotto, M., Bauer, R.

“…The relative bioavailability of the major alkamides, dodeca-2 E,4 E,8 Z,10 E/ Z-tetraenoic acid isobutylamides, from Echinacea purpurea phytotherapeutic…”
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Drug Nanocrystals: Theoretical Background of Solubility Increase and Dissolution Rate Enhancement by Hasa, D

“…The peculiar higher solubility of drug nanocrystals compared to macrocrystals appeals to the pharmaceutical field. Indeed, until now, about 70 % of the…”
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Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymers by Voinovich, D, Perissutti, B, Magarotto, L, Ceschia, D, Guiotto, P, Bilia, A R

“…Simultaneous improvement of solubilization kinetics of main flavolignans of Silybum marianum extract was obtained cogrinding with two crosslinked polymers:…”
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Preparation in high-shear mixer of sustained-release pellets by melt pelletisation by Voinovich, D., Moneghini, M., Perissutti, B., Filipovic-Grcic, J., Grabnar, I.

“…The preparation of sustained-release pellets by melt pelletisation was investigated in a 10-l high shear mixer and ternary mixtures containing stearic acid as…”
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Spray-dried chitosan ethylcellulose microspheres for nasal drug delivery: Swelling study and evaluation of in vitro drug release properties by Martinac, A., Filipovi -Gr i, J., Perissutti, B., Voinovich, D., Paveli, .

“…The aim of this study was to develop spray-dried chitosan-based microspheres, suitable for nasal delivery of loratadine, and to evaluate their potential of…”
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Studies in dissolution enhancement of atenolol. Part I by Moneghini, M., Carcano, A., Zingone, G., Perissutti, B.

“…The objective of this study was to design atenolol tablets with fast in vitro release rates. Different polymers were screened as possible carriers to enhance…”
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Characterisation of nimesulide–betacyclodextrins systems prepared by supercritical fluid impregnation by Moneghini, M., Kikic, I., Perissutti, B., Franceschinis, E., Cortesi, A.

“…The purpose of this study was to apply the supercritical CO 2 impregnation process for preparing solvent-free nimesulide (NMS)–betacyclodextrins (BCD)…”
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Supercritical antisolvent precipitation of nimesulide: preliminary experiments by Moneghini, M, Perissutti, B, Vecchione, F, Kikic, I, Alessi, P, Cortesi, A, Princivalle, F

“…The purpose of this preliminary study was to investigate the physico-chemical properties of nimesulide precipitated by continuous supercritical antisolvent…”
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Study on polymer-surfactant interactions for the improvement of drug delivery systems wettability by De Simone, I, Coceani, N, Farra, R, Fiorentino, S.M, Grassi, G, Lapasin, R, Hasa, D, Perissutti, B, Grassi, M, Voinovich, D

“…One of the possible causes of failure of the mechanochemical activation of poorly soluble drugs relies on the scarce drug wettability. Indeed, the…”
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