Search Results - "Perini, Giovanni"

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability by Milazzo, Giorgio, Mercatelli, Daniele, Di Muzio, Giulia, Triboli, Luca, De Rosa, Piergiuseppe, Perini, Giovanni, Giorgi, Federico M

“…Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors,…”
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Restoration of the molecular clock is tumor suppressive in neuroblastoma by Moreno-Smith, Myrthala, Milazzo, Giorgio, Tao, Ling, Fekry, Baharan, Zhu, Bokai, Mohammad, Mahmoud A., Di Giacomo, Simone, Borkar, Roshan, Reddy, Karthik Reddy Kami, Capasso, Mario, Vasudevan, Sanjeev A., Sumazin, Pavel, Hicks, John, Putluri, Nagireddy, Perini, Giovanni, Eckel-Mahan, Kristin, Burris, Thomas P., Barbieri, Eveline

“…MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its…”
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The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription by Wong, Matthew, Tee, Andrew E L, Milazzo, Giorgio, Bell, Jessica L, Poulos, Rebecca C, Atmadibrata, Bernard, Sun, Yuting, Jing, Duohui, Ho, Nicholas, Ling, Dora, Liu, Pei Yan, Zhang, Xu Dong, Hüttelmaier, Stefan, Wong, Jason W H, Wang, Jenny, Polly, Patsie, Perini, Giovanni, Scarlett, Christopher J, Liu, Tao

“…Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of…”
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HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder by Trazzi, Stefania, Fuchs, Claudia, Viggiano, Rocchina, De Franceschi, Marianna, Valli, Emanuele, Jedynak, Paulina, Hansen, Finn K, Perini, Giovanni, Rimondini, Roberto, Kurz, Thomas, Bartesaghi, Renata, Ciani, Elisabetta

“…Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase predominantly expressed in the brain. Mutations of the CDKL5 gene lead to CDKL5 disorder, a…”
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MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma by Tao, Ling, Mohammad, Mahmoud A., Milazzo, Giorgio, Moreno-Smith, Myrthala, Patel, Tajhal D., Zorman, Barry, Badachhape, Andrew, Hernandez, Blanca E., Wolf, Amber B., Zeng, Zihua, Foster, Jennifer H., Aloisi, Sara, Sumazin, Pavel, Zu, Youli, Hicks, John, Ghaghada, Ketan B., Putluri, Nagireddy, Perini, Giovanni, Coarfa, Cristian, Barbieri, Eveline

“…Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients;…”
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PRDM12 in Health and Diseases by Rienzo, Monica, Di Zazzo, Erika, Casamassimi, Amelia, Gazzerro, Patrizia, Perini, Giovanni, Bifulco, Maurizio, Abbondanza, Ciro

“…PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1) homologous domain (PRDM)-containing protein family, a subfamily of…”
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The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 by Liu, Pei Y., Tee, Andrew E., Milazzo, Giorgio, Hannan, Katherine M., Maag, Jesper, Mondal, Sujanna, Atmadibrata, Bernard, Bartonicek, Nenad, Peng, Hui, Ho, Nicholas, Mayoh, Chelsea, Ciaccio, Roberto, Sun, Yuting, Henderson, Michelle J., Gao, Jixuan, Everaert, Celine, Hulme, Amy J., Wong, Matthew, Lan, Qing, Cheung, Belamy B., Shi, Leming, Wang, Jenny Y., Simon, Thorsten, Fischer, Matthias, Zhang, Xu D., Marshall, Glenn M., Norris, Murray D., Haber, Michelle, Vandesompele, Jo, Li, Jinyan, Mestdagh, Pieter, Hannan, Ross D., Dinger, Marcel E., Perini, Giovanni, Liu, Tao

“…The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our…”
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Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs by Ciaccio, Roberto, De Rosa, Piergiuseppe, Aloisi, Sara, Viggiano, Marta, Cimadom, Leonardo, Zadran, Suleman Khan, Perini, Giovanni, Milazzo, Giorgio

“…Neuroblastoma (NB) is one of the most frequently occurring neurogenic extracranial solid cancers in childhood and infancy. Over the years, many pieces of…”
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MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells by De Rosa, Piergiuseppe, Severi, Federica, Zadran, Suleman Khan, Russo, Marco, Aloisi, Sara, Rigamonti, Alberto, Capranico, Giovanni, Milazzo, Giorgio, Perini, Giovanni

“…Neuroblastoma (NB) is one of the primary causes of death for pediatric malignancies. Given the high heterogeneity in NB's mutation landscape, optimizing…”
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JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma by Wong, Matthew, Sun, Yuting, Xi, Zhichao, Milazzo, Giorgio, Poulos, Rebecca C., Bartenhagen, Christoph, Bell, Jessica L., Mayoh, Chelsea, Ho, Nicholas, Tee, Andrew E., Chen, Xiaoqiong, Li, Yang, Ciaccio, Roberto, Liu, Pei Y., Jiang, Chen C., Lan, Qing, Jayatilleke, Nisitha, Cheung, Belamy B., Haber, Michelle, Norris, Murray D., Zhang, Xu D., Marshall, Glenn M., Wang, Jenny Y., Hüttelmaier, Stefan, Fischer, Matthias, Wong, Jason W. H., Xu, Hongxi, Perini, Giovanni, Dong, Qihan, George, Rani E., Liu, Tao

“…Chromosome 17q21-ter is commonly gained in neuroblastoma, but it is unclear which gene in the region is important for tumorigenesis. The JMJD6 gene at…”
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Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression by Liu, Pei Y, Erriquez, Daniela, Marshall, Glenn M, Tee, Andrew E, Polly, Patsie, Wong, Mathew, Liu, Bing, Bell, Jessica L, Zhang, Xu D, Milazzo, Giorgio, Cheung, Belamy B, Fox, Archa, Swarbrick, Alexander, Hüttelmaier, Stefan, Kavallaris, Maria, Perini, Giovanni, Mattick, John S, Dinger, Marcel E, Liu, Tao

“…Patients with neuroblastoma due to the amplification of a 130-kb genomic DNA region containing the MYCN oncogene have poor prognoses. Bioinformatics data were…”
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Mutations in the 5′ UTR of ANKRD26, the Ankirin Repeat Domain 26 Gene, Cause an Autosomal-Dominant Form of Inherited Thrombocytopenia, THC2 by Pippucci, Tommaso, Savoia, Anna, Perrotta, Silverio, Pujol-Moix, Núria, Noris, Patrizia, Castegnaro, Giovanni, Pecci, Alessandro, Gnan, Chiara, Punzo, Francesca, Marconi, Caterina, Gherardi, Samuele, Loffredo, Giuseppe, De Rocco, Daniela, Scianguetta, Saverio, Barozzi, Serena, Magini, Pamela, Bozzi, Valeria, Dezzani, Luca, Di Stazio, Mariateresa, Ferraro, Marcella, Perini, Giovanni, Seri, Marco, Balduini, Carlo L.

“…THC2, an autosomal-dominant thrombocytopenia described so far in only two families, has been ascribed to mutations in MASTL or ACBD5. Here, we show that…”
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The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome by Trazzi, Stefania, Fuchs, Claudia, Valli, Emanuele, Perini, Giovanni, Bartesaghi, Renata, Ciani, Elisabetta

“…Intellectual disability in Down syndrome (DS) appears to be related to severe proliferation impairment during brain development. Recent evidence shows that it…”
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Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma by Amente, Stefano, Milazzo, Giorgio, Sorrentino, Maria Cristina, Ambrosio, Susanna, Di Palo, Giacomo, Lania, Luigi, Perini, Giovanni, Majello, Barbara

“…The chromatin-modifying enzyme lysine-specific demethylase 1, KDM1A/LSD1 is involved in maintaining the undifferentiated, malignant phenotype of neuroblastoma…”
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p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma by LINDI CHEN, IRACI, Nunzio, GHERARDI, Samuele, GAMBLE, Laura D, WOOD, Katrina M, PERINI, Giovanni, LUNEC, John, TWEDDLE, Deborah A

“…MYCN amplification occurs in approximately 25% of neuroblastomas, where it is associated with rapid tumor progression and poor prognosis. MYCN plays a…”
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SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability by Marshall, Glenn M, Liu, Pei Y, Gherardi, Samuele, Scarlett, Christopher J, Bedalov, Antonio, Xu, Ning, Iraci, Nuncio, Valli, Emanuele, Ling, Dora, Thomas, Wayne, van Bekkum, Margo, Sekyere, Eric, Jankowski, Kacper, Trahair, Toby, Mackenzie, Karen L, Haber, Michelle, Norris, Murray D, Biankin, Andrew V, Perini, Giovanni, Liu, Tao

“…The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc…”
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MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma by Agarwal, Saurabh, Milazzo, Giorgio, Rajapakshe, Kimal, Bernardi, Ronald, Chen, Zaowen, Barbieri, Eveline, Koster, Jan, Perini, Giovanni, Coarfa, Cristian, Shohet, Jason M

“…The MYC oncogenes and p53 have opposing yet interrelated roles in normal development and tumorigenesis. How MYCN expression alters the biology and clinical…”
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Non-coding RNAs in muscle dystrophies by Erriquez, Daniela, Perini, Giovanni, Ferlini, Alessandra

“…ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of…”
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Epigenetic origin of evolutionary novel centromeres by Tolomeo, Doron, Capozzi, Oronzo, Stanyon, Roscoe R., Archidiacono, Nicoletta, D’Addabbo, Pietro, Catacchio, Claudia R., Purgato, Stefania, Perini, Giovanni, Schempp, Werner, Huddleston, John, Malig, Maika, Eichler, Evan E., Rocchi, Mariano

“…Most evolutionary new centromeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications. However, the hypothesis is that…”
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ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux by Henderson, Michelle J., Haber, Michelle, Porro, Antonio, Munoz, Marcia A., Iraci, Nunzio, Xue, Chengyuan, Murray, Jayne, Flemming, Claudia L., Smith, Janice, Fletcher, Jamie I., Gherardi, Samuele, Kwek, Chin-Kiat, Russell, Amanda J., Valli, Emanuele, London, Wendy B., Buxton, Allen B., Ashton, Lesley J., Sartorelli, Alan C., Cohn, Susan L., Schwab, Manfred, Marshall, Glenn M., Perini, Giovanni, Norris, Murray D.

“…Background Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their…”
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