Search Results - "Perin, Stefano"
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Designing an effective dissolution test for bilayer tablets tailored for optimal melatonin release in sleep disorder management
Published in Frontiers in nutrition (Lausanne) (06-05-2024)“…This project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep…”
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Folding of Class IIa HDAC Derived Peptides into α-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA
Published in Journal of molecular biology (01-05-2024)“…[Display omitted] •MEF2 serves as a versatile adaptor mediating interactions with multiple class IIa HDAC peptide motifs.•Binding class IIa HDAC derived…”
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A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue
Published in Bioorganic & medicinal chemistry (15-11-2023)“…[Display omitted] The inhibition of human urokinase-type plasminogen activator (huPA), a serine protease that plays an important role in pericellular…”
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Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription
Published in Nucleic acids research (21-03-2022)“…Abstract In leiomyosarcoma class IIa HDACs (histone deacetylases) bind MEF2 and convert these transcription factors into repressors to sustain proliferation…”
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Safety and efficacy of substance-based medical devices: Design of an in vitro barrier effect test
Published in Frontiers in Drug Safety and Regulation (11-04-2023)“…This study aims to develop an in vitro barrier effect test over biomimetic membrane, which is useful to establish the film forming ability of a substance-based…”
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Effects of Betahistine on Vestibular Receptors of the Frog
Published in Acta oto-laryngologica (1998)“…Betahistine is widely used in the symptomatic treatment of peripheral and central vestibular disorders. However, its remains unknown whether the drug can act…”
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