Search Results - "Perim, Raphael"

Cervical spinal hemisection effects on spinal tissue oxygenation and long-term facilitation of phrenic, renal and splanchnic sympathetic nerve activity by Perim, Raphael R., Vinit, Stéphane, Mitchell, Gordon S.

“…Moderate acute intermittent hypoxia (mAIH) elicits plasticity in both respiratory (phrenic long-term facilitation; pLTF) and sympathetic nerve activity…”
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Cervical spinal injury compromises caudal spinal tissue oxygenation and undermines acute intermittent hypoxia-induced phrenic long-term facilitation by Perim, Raphael R., Gonzalez-Rothi, Elisa J., Mitchell, Gordon S.

“…An important model of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent increase in phrenic burst amplitude following acute…”
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Protein kinase Cδ constrains the S‐pathway to phrenic motor facilitation elicited by spinal 5‐HT7 receptors or severe acute intermittent hypoxia by Perim, Raphael R., Fields, Daryl P., Mitchell, Gordon S.

“…Key points Concurrent 5‐HT2A (Q pathway) and 5‐HT7 (S pathway) serotonin receptor activation cancels phrenic motor facilitation due to mutual cross‐talk…”
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Protein kinase Cδ constrains the S-pathway to phrenic motor facilitation elicited by spinal 5-HT 7 receptors or severe acute intermittent hypoxia by Perim, Raphael R, Fields, Daryl P, Mitchell, Gordon S

“…Concurrent 5-HT (Q pathway) and 5-HT (S pathway) serotonin receptor activation cancels phrenic motor facilitation due to mutual cross-talk inhibition. Spinal…”
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Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity by Tadjalli, Arash, Seven, Yasin B, Perim, Raphael R, Mitchell, Gordon S

“…Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been…”
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Circulatory control of phrenic motor plasticity by Perim, Raphael R., Mitchell, Gordon S.

“…•Cardiovascular changes that compromise oxygen availability in spinal cord tissue might impact expression of respiratory motor plasticity.•Impaired circulatory…”
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Hypoxia-induced hypotension elicits adenosine-dependent phrenic long-term facilitation after carotid denervation by Perim, Raphael R., Kubilis, Paul S., Seven, Yasin B., Mitchell, Gordon S.

“…Moderate acute intermittent hypoxia (AIH) elicits a persistent, serotonin-dependent increase in phrenic amplitude, known as phrenic long-term facilitation…”
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Synergy between Acute Intermittent Hypoxia and Task-Specific Training by Welch, Joseph F., Sutor, Tommy W., Vose, Alicia K., Perim, Raphael R., Fox, Emily J., Mitchell, Gordon S.

“…Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms…”
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Acute intermittent hypoxia elicits sympathetic neuroplasticity independent of peripheral chemoreflex activation and spinal cord tissue hypoxia in a rodent model of high-thoracic spinal cord injury by Ahmadian, Mehdi, Erskine, Erin, Wainman, Liisa, Wearing, Oliver H., Duffy, Jennifer S., Stewart, Liam C., Hoiland, Ryan L., Taki, Alissa, Perim, Raphael R., Mitchell, Gordon S., Little, Jonathan P., Mueller, Patrick J., Foster, Glen E., West, Christopher R.

“…The loss of medullary control of spinal circuits controlling the heart and blood vessels is a unifying mechanism linking both hemodynamic instability and the…”
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Baseline Arterial CO2 Pressure Regulates Acute Intermittent Hypoxia-Induced Phrenic Long-Term Facilitation in Rats by Perim, Raphael R., El-Chami, Mohamed, Gonzalez-Rothi, Elisa J., Mitchell, Gordon S.

“…Moderate acute intermittent hypoxia (mAIH) elicits a progressive increase in phrenic motor output lasting hours post-mAIH, a form of respiratory motor…”
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Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats by Perim, Raphael R, Sunshine, Michael D, Welch, Joseph F, Santiago, Juliet, Holland, Ashley, Ross, Ashley, Mitchell, Gordon S, Gonzalez-Rothi, Elisa J

“…Plasticity is a hallmark of the respiratory neural control system. Phrenic long-term facilitation (pLTF) is one form of respiratory plasticity characterized by…”
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Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation by Seven, Yasin B., Perim, Raphael R., Hobson, Orinda R., Simon, Alec K., Tadjalli, Arash, Mitchell, Gordon S.

“…Key points Although adenosine 2A (A2A) receptor activation triggers specific cell signalling cascades, the ensuing physiological outcomes depend on the…”
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Effect of acute intermittent hypoxia on cortico-diaphragmatic conduction in healthy humans by Welch, Joseph F., Perim, Raphael R., Argento, Patrick J., Sutor, Tommy W., Vose, Alicia K., Nair, Jayakrishnan, Mitchell, Gordon S., Fox, Emily J.

“…Acute intermittent hypoxia (AIH) is a strategy to improve motor output in humans with neuromotor impairment. A single AIH session increases the amplitude of…”
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Cross-talk inhibition between 5-HT 2B and 5-HT 7 receptors in phrenic motor facilitation via NADPH oxidase and PKA by Perim, Raphael R, Fields, Daryl P, Mitchell, Gordon S

“…Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation…”
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Previous exposure to chronic intermittent hypoxia blunts the development of one‐kidney, one‐clip hypertension in rats by Perim, Raphael R., Amorim, Mateus R., Bonagamba, The Late Leni G. H., Machado, Benedito H.

“…New Findings What is the central question of this study? Chronic intermittent hypoxia (CIH) and one‐kidney, one‐clip experimental models lead to sympathetic…”
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Magnitude and Mechanism of Phrenic Long-term Facilitation Shift Between Daily Rest Versus Active Phase by Marciante, Alexandria B, Seven, Yasin B, Kelly, Mia N, Perim, Raphael R, Mitchell, Gordon S

“…Abstract Plasticity is a fundamental property of the neural system controlling breathing. One key example of respiratory motor plasticity is phrenic long-term…”
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Cardiovascular and respiratory outcome of preconditioned rats submitted to chronic intermittent hypoxia by Perim, Raphael R., Bonagamba, Leni G. H., Machado, Benedito H.

“…New Findings What is the central question of this study? What are the effects of hypoxic preconditioning upon the cardiovascular and respiratory responses to…”
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Differential spinal tissue oxygen profile during moderate and severe acute intermittent hypoxia by Perim, Raphael Rodrigues, Mitchell, Gordon S.

“…Abstract only Plasticity is a hallmark of the neural system controlling breathing. A frequently studied model of respiratory motor plasticity is phrenic…”
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Pattern of Acute Intermittent Hypoxia Protocol Impacts Phrenic Long-term Facilitation by Marciante, Alexandria, Seven, Yasin, Perim, Raphael, Mitchell, Gordon

“…Abstract only An important model of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a prolonged increase in phrenic nerve activity…”
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Spinal NMDA receptor activation is necessary to initiate but not maintain ampakine-hypoxia induced phrenic motor facilitation by Thakre, Prajwal, Perim, Raphael, Mitchell, Gordon, Fuller, David

“…Abstract only Ampakines are a class of compounds which act as positive allosteric modulators of AMPA receptors. Intravenous (i.v.) delivery of a “low impact”…”
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