Search Results - "Peri, Francesco"

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling by Cochet, Florent, Peri, Francesco

“…The interactions between sugar-containing molecules from the bacteria cell wall and pattern recognition receptors (PRR) on the plasma membrane or cytosol of…”
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Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update by Peri, Francesco, Calabrese, Valentina

“…Toll-like receptor 4 (TLR4), together with MD-2, binds bacterial endotoxins (E) with high affinity, triggering formation of the activated homodimer…”
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Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Overview by Romerio, Alessio, Peri, Francesco

“…Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs)…”
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Cleaner synthesis of preclinically validated vaccine adjuvants by Romerio, Alessio, Peri, Francesco

“…We developed synthetic glycophospholipids based on a glucosamine core (FP compounds) with potent and selective activity in stimulating Toll-Like Receptor 4…”
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Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory by Artusa, Valentina, Calabrone, Luana, Mortara, Lorenzo, Peri, Francesco, Bruno, Antonino

“…Cancer stem cells (CSCs) have drawn much attention as important tumour-initiating cells that may also be crucial for recurrence after chemotherapy. Although…”
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Developing New Anti-Tuberculosis Vaccines: Focus on Adjuvants by Franco, Ana Rita, Peri, Francesco

“…Tuberculosis (TB) is an infectious disease caused by (Mtb) that sits in the top 10 leading causes of death in the world today and is the current leading cause…”
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TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis by Kuzmich, Nikolay N, Sivak, Konstantin V, Chubarev, Vladimir N, Porozov, Yuri B, Savateeva-Lyubimova, Tatiana N, Peri, Francesco

“…Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is…”
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Chemistry of Lipid A: At the Heart of Innate Immunity by Molinaro, Antonio, Holst, Otto, Di Lorenzo, Flaviana, Callaghan, Maire, Nurisso, Alessandra, D'Errico, Gerardino, Zamyatina, Alla, Peri, Francesco, Berisio, Rita, Jerala, Roman, Jiménez-Barbero, Jesús, Silipo, Alba, Martín-Santamaría, Sonsoles

“…In many Gram‐negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries…”
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A Global Picture of Molecular Changes Associated to LPS Treatment in THP-1 Derived Human Macrophages by Fourier Transform Infrared Microspectroscopy by Ami, Diletta, Franco, Ana Rita, Artusa, Valentina, Mereghetti, Paolo, Peri, Francesco, Natalello, Antonino

“…Macrophages are among the first immune cells involved in the initiation of the inflammatory response to protect the host from pathogens. THP-1 derived…”
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Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection by Italia, Alice, Shaik, Mohammed Monsoor, Peri, Francesco

“…Emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed…”
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New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants by Romerio, Alessio, Gotri, Nicole, Franco, Ana Rita, Artusa, Valentina, Shaik, Mohammed Monsoor, Pasco, Samuel T., Atxabal, Unai, Matamoros-Recio, Alejandra, Mínguez-Toral, Marina, Zalamea, Juan Diego, Franconetti, Antonio, Abrescia, Nicola G. A., Jimenez-Barbero, Jesus, Anguita, Juan, Martín-Santamaría, Sonsoles, Peri, Francesco

“…We disclose here a panel of small-molecule TLR4 agonists (the FP20 series) whose structure is derived from previously developed TLR4 ligands (FP18 series). The…”
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Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists by Facchini, Fabio A, Zaffaroni, Lenny, Minotti, Alberto, Rapisarda, Silvia, Calabrese, Valentina, Forcella, Matilde, Fusi, Paola, Airoldi, Cristina, Ciaramelli, Carlotta, Billod, Jean-Marc, Schromm, Andra B, Braun, Harald, Palmer, Charys, Beyaert, Rudi, Lapenta, Fabio, Jerala, Roman, Pirianov, Grisha, Martin-Santamaria, Sonsoles, Peri, Francesco

“…The structure–activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and…”
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Selective SERCA2a activator as a candidate for chronic heart failure therapy by Arici, Martina, Hsu, Shih-Che, Ferrandi, Mara, Barassi, Paolo, Ronchi, Carlotta, Torre, Eleonora, Luraghi, Andrea, Chang, Gwo-Jyh, Ferrari, Patrizia, Bianchi, Giuseppe, Peri, Francesco, Zaza, Antonio, Rocchetti, Marcella

“…The sarcoplasmic reticulum (SR) Ca ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that…”
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Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity by Bianco, Annalisa, Reghellin, Veronica, Donnici, Lorena, Fenu, Simone, Alvarez, Reinaldo, Baruffa, Chiara, Peri, Francesco, Pagani, Massimiliano, Abrignani, Sergio, Neddermann, Petra, De Francesco, Raffaele

“…4-anilino quinazolines have been identified as inhibitors of HCV replication. The target of this class of compounds was proposed to be the viral protein NS5A,…”
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Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling by Sestito, Stefania E, Facchini, Fabio A, Morbioli, Ilaria, Billod, Jean-Marc, Martin-Santamaria, Sonsoles, Casnati, Alessandro, Sansone, Francesco, Peri, Francesco

“…We recently reported on the activity of cationic amphiphiles in inhibiting TLR4 activation and subsequent production of inflammatory cytokines in cells and in…”
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Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model by De Paola, Massimiliano, Sestito, Stefania E., Mariani, Alessandro, Memo, Christian, Fanelli, Roberto, Freschi, Mattia, Bendotti, Caterina, Calabrese, Valentina, Peri, Francesco

“…[Display omitted] Increasing evidence indicates that inflammatory responses could play a critical role in the pathogenesis of motor neuron injury in…”
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Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice by Bettoni, Isabella, Comelli, Francesca, Rossini, Clara, Granucci, Francesca, Giagnoni, Gabriella, Peri, Francesco, Costa, Barbara

“…Neuropathic pain remains a prevalent clinical problem because it is often poorly responsive to the currently used analgesics, thus it is crucial the…”
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A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice by Balu, Deebika, Valencia-Olvera, Ana C, Nguyen, Austin, Patnam, Mehul, York, Jason, Peri, Francesco, Neumann, Frank, LaDu, Mary Jo, Tai, Leon M

“…APOE genotype is the greatest genetic risk factor for sporadic Alzheimer's disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect…”
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A new advanced cellular model of functional cholinergic-like neurons developed by reprogramming the human SH-SY5Y neuroblastoma cell line by D’Aloia, Alessia, Pastori, Valentina, Blasa, Stefania, Campioni, Gloria, Peri, Francesco, Sacco, Elena, Ceriani, Michela, Lecchi, Marzia, Costa, Barbara

“…Modeling human neuronal properties in physiological and pathological conditions is essential to identify novel potential drugs and to explore pathological…”
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Dye-Sensitized Photocatalytic Hydrogen Generation: Efficiency Enhancement by Organic Photosensitizer–Coadsorbent Intermolecular Interaction by Manfredi, Norberto, Monai, Matteo, Montini, Tiziano, Peri, Francesco, De Angelis, Filippo, Fornasiero, Paolo, Abbotto, Alessandro

“…Dye-sensitized photocatalytic H2 generation has been investigated using a metal-free phenothiazine-based donor–acceptor sensitizer (PTZ-GLU) in combination…”
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