Search Results - "Perham, Matthew"

ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation by Goess, Christian, Harris, Christopher M., Murdock, Sara, McCarthy, Richard W., Sampson, Erik, Twomey, Rachel, Mathieu, Suzanne, Mario, Regina, Perham, Matthew, Goedken, Eric R., Long, Andrew J.

“…Objectives: Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase required for intracellular signaling downstream of multiple immunoreceptors. We…”
Get full text

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome by Cool, Barbara, Zinker, Bradley, Chiou, William, Kifle, Lemma, Cao, Ning, Perham, Matthew, Dickinson, Robert, Adler, Andrew, Gagne, Gerard, Iyengar, Rajesh, Zhao, Gang, Marsh, Kennan, Kym, Philip, Jung, Paul, Camp, Heidi S., Frevert, Ernst

“…AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and whole-body energy metabolism. We have identified a thienopyridone family…”
Get full text

Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712 by Breinlinger, Eric, Van Epps, Stacy, Friedman, Michael, Argiriadi, Maria, Chien, Ellen, Chhor, Gekleng, Cowart, Marlon, Dunstan, Theresa, Graff, Candace, Hardee, David, Herold, J. Martin, Little, Andrew, McCarthy, Richard, Parmentier, Julie, Perham, Matthew, Qiu, Wei, Schrimpf, Michael, Vargo, Thomas, Webster, Matthew P., Wu, Fei, Bennett, Dawn, Edmunds, Jeremy

“…Tyrosine kinase 2 (TYK2) is a nonreceptor tyrosine kinase that belongs to the JAK family also comprising JAK1, JAK2, and JAK3. TYK2 is an attractive target for…”
Get full text

Enhanced Fat Metabolism and Reversal of Insulin Resistance by Aceytl-CoA Carboxylase 1&2 Inhibition in Diet Induced Obese Mice by Adler, Andrew L, Perham, Matthew A, McNally, Teresa, Yu-Gui, Gu

Get full text