Search Results - "Perga, Simona"

NURR1 Impairment in Multiple Sclerosis by Montarolo, Francesca, Martire, Serena, Perga, Simona, Bertolotto, Antonio

“…The transcription factor NURR1 is a constitutively active orphan receptor belonging to the steroid hormone receptor class NR4A. Although a genetic association…”
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TNFAIP3 Deficiency Affects Monocytes, Monocytes-Derived Cells and Microglia in Mice by Montarolo, Francesca, Perga, Simona, Tessarolo, Carlotta, Spadaro, Michela, Martire, Serena, Bertolotto, Antonio

“…The intracellular-ubiquitin-ending-enzyme tumor necrosis factor alpha-induced protein 3 (TNFAIP3) is a potent inhibitor of the pro-inflammatory nuclear factor…”
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NURR1 deficiency is associated to ADHD-like phenotypes in mice by Montarolo, Francesca, Martire, Serena, Perga, Simona, Spadaro, Michela, Brescia, Irene, Allegra, Sarah, De Francia, Silvia, Bertolotto, Antonio

“…The transcription factor NURR1 regulates the dopamine (DA) signaling pathway and exerts a critical role in the development of midbrain dopaminergic neurons…”
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A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients by Martire, Serena, Navone, Nicole D, Montarolo, Francesca, Perga, Simona, Bertolotto, Antonio

“…Abstract We studied the baseline expression level of 25 interferon-regulated genes (MxA, GPR3, IL17RC, ISG15, TRAIL, OASL, IFIT1, IFIT2, RSAD2, OAS3, IFI44L,…”
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Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson’s and Alzheimer’s Disease Patients by Montarolo, Francesca, Perga, Simona, Martire, Serena, Navone, Désirée Nicole, Marchet, Alberto, Leotta, Daniela, Bertolotto, Antonio

“…Parkinson’s disease (PD) is a neurodegenerative pathology characterized by the degeneration of midbrain dopamine neurons, whose development and maintenance in…”
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Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice by Montarolo, Francesca, Raffaele, Chiara, Perga, Simona, Martire, Serena, Finardi, Annamaria, Furlan, Roberto, Hintermann, Samuel, Bertolotto, Antonio

“…Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) characterized by immune-mediated inflammation, demyelination and…”
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A First Phenotypic and Functional Characterization of Placental Extracellular Vesicles from Women with Multiple Sclerosis by Martire, Serena, Montarolo, Francesca, Spadaro, Michela, Perga, Simona, Sforza, Maria Ludovica, Marozio, Luca, Frezet, Federica, Bruno, Stefania, Chiabotto, Giulia, Deregibus, Maria Chiara, Camussi, Giovanni, Botta, Giovanni, Benedetto, Chiara, Bertolotto, Antonio

“…Pregnancy is a unique situation of physiological immunomodulation, as well as a strong Multiple Sclerosis (MS) disease modulator whose mechanisms are still…”
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Neuronal Membrane Cholesterol Loss Enhances Amyloid Peptide Generation by Abad-Rodriguez, Jose, Ledesma, Maria Dolores, Craessaerts, Katleen, Perga, Simona, Medina, Miguel, Delacourte, Andre, Dingwall, Colin, De Strooper, Bart, Dotti, Carlos G.

“…Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However,…”
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Immunomodulatory Effect of Pregnancy on Leukocyte Populations in Patients With Multiple Sclerosis: A Comparison of Peripheral Blood and Decidual Placental Tissue by Spadaro, Michela, Martire, Serena, Marozio, Luca, Mastromauro, Daniela, Montanari, Elena, Perga, Simona, Montarolo, Francesca, Brescia, Federica, Balbo, Alessia, Botta, Giovanni, Benedetto, Chiara, Bertolotto, Antonio

“…Pregnancy is a naturally occurring disease modifier of multiple sclerosis (MS) associated with a substantial reduction in relapse rate. To date, attempts to…”
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Vitamin D Binding Protein Isoforms and Apolipoprotein E in Cerebrospinal Fluid as Prognostic Biomarkers of Multiple Sclerosis by Perga, Simona, Giuliano Albo, Alessandra, Lis, Katarzyna, Minari, Nicoletta, Falvo, Sara, Marnetto, Fabiana, Caldano, Marzia, Reviglione, Raffaella, Berchialla, Paola, Capobianco, Marco A, Malentacchi, Maria, Corpillo, Davide, Bertolotto, Antonio

“…Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a heterogeneous and unpredictable course. To date there are…”
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The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice by Valsecchi, Valeria, Boido, Marina, Montarolo, Francesca, Guglielmotto, Michela, Perga, Simona, Martire, Serena, Cutrupi, Santina, Iannello, Andrea, Gionchiglia, Nadia, Signorino, Elena, Calvo, Andrea, Fuda, Giuseppe, Chiò, Adriano, Bertolotto, Antonio, Vercelli, Alessandro

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects both lower and upper motor neurons (MNs) in the central nervous system. ALS…”
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The Footprints of Poly-Autoimmunity: Evidence for Common Biological Factors Involved in Multiple Sclerosis and Hashimoto's Thyroiditis by Perga, Simona, Martire, Serena, Montarolo, Francesca, Giordani, Ilaria, Spadaro, Michela, Bono, Gabriele, Corvisieri, Stefania, Messuti, Ilaria, Panzica, Giancarlo, Orlandi, Fabio, Bertolotto, Antonio

“…Autoimmune diseases are a diverse group of chronic disorders and affect a multitude of organs and systems. However, the existence of common pathophysiological…”
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Application of Microsatellites to Trace the Dairy Products Back to the Farm of Origin by Perga, Simona, Biolatti, Cristina, Martini, Isabella, Rossi, Francesco, Benso, Alfredo, Acutis, Pier Luigi, Bagnato, Alessandro, Cognata, Domenico, Caroggio, Piero, Peletto, Simone, Modesto, Paola

“…The increasing number of food frauds, mainly targeting high quality products, is a rising concern among producers and authorities appointed to food controls…”
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Overexpression of the ubiquitin‐editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation by Perga, Simona, Montarolo, Francesca, Martire, Serena, Bonaldo, Brigitta, Bono, Gabriele, Bertolo, Jessica, Magliozzi, Roberta, Bertolotto, Antonio

“…Multiple Sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) in which inflammation plays a key pathological role. Recent…”
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In vivo silencing of miR‐125a‐3p promotes myelin repair in models of white matter demyelination by Marangon, Davide, Boda, Enrica, Parolisi, Roberta, Negri, Camilla, Giorgi, Corinna, Montarolo, Francesca, Perga, Simona, Bertolotto, Antonio, Buffo, Annalisa, Abbracchio, Maria P., Lecca, Davide

“…In the last decade, microRNAs have been increasingly recognized as key modulators of glial development. Recently, we identified miR‐125a‐3p as a new player in…”
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Nurr1 reduction influences the onset of chronic EAE in mice by Montarolo, Francesca, Perga, Simona, Martire, Serena, Bertolotto, Antonio

“…Objective Nurr1 plays anti-inflammatory functions in astrocytes/microglia. Gene expression analysis reveals Nurr1 down-regulation in PBMCs of MS patients that…”
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Biological activity of glatiramer acetate on Treg and anti-inflammatory monocytes persists for more than 10 years in responder multiple sclerosis patients by Spadaro, Michela, Montarolo, Francesca, Perga, Simona, Martire, Serena, Brescia, Federica, Malucchi, Simona, Bertolotto, Antonio

“…Abstract Glatiramer acetate (GA) is a widely used treatment for multiple sclerosis (MS), with incompletely defined mechanism of action. Short-term studies…”
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A20 in Multiple Sclerosis and Parkinson’s Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways? by Perga, Simona, Martire, Serena, Montarolo, Francesca, Navone, Nicole D., Calvo, Andrea, Fuda, Giuseppe, Marchet, Alberto, Leotta, Daniela, Chiò, Adriano, Bertolotto, Antonio

“…Chronic inflammation significantly contributes to the pathogenesis of several neurodegenerative disorders. In physiological conditions, a chronic inflammatory…”
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Biological activity of glatiramer acetate on Treg and anti-inflammatory monocytes persists for more than 10years in responder multiple sclerosis patients by Spadaro, Michela, Montarolo, Francesca, Perga, Simona, Martire, Serena, Brescia, Federica, Malucchi, Simona, Bertolotto, Antonio

“…Glatiramer acetate (GA) is a widely used treatment for multiple sclerosis (MS), with incompletely defined mechanism of action. Short-term studies suggested its…”
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Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility by Zuccalà, Miriam, Barizzone, Nadia, Boggio, Elena, Gigliotti, Luca, Sorosina, Melissa, Basagni, Chiara, Bordoni, Roberta, Clarelli, Ferdinando, Anand, Santosh, Mangano, Eleonora, Vecchio, Domizia, Corsetti, Elena, Martire, Serena, Perga, Simona, Ferrante, Daniela, Gajofatto, Alberto, Ivashynka, Andrei, Solaro, Claudio, Cantello, Roberto, Martinelli, Vittorio, Comi, Giancarlo, Filippi, Massimo, Esposito, Federica, Leone, Maurizio, De Bellis, Gianluca, Dianzani, Umberto, Martinelli-Boneschi, Filippo, D'Alfonso, Sandra

“…Among multiple sclerosis (MS) susceptibility genes, the strongest non-human leukocyte antigen (HLA) signal in the Italian population maps to the TNFSF14 gene…”
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