Search Results - "Perfect, Hahdi H."

Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin by Bowles, Paul, Brenek, Steven J, Caron, Stéphane, Do, Nga M, Drexler, Michele T, Duan, Shengquan, Dubé, Pascal, Hansen, Eric C, Jones, Brian P, Jones, Kris N, Ljubicic, Tomislav A, Makowski, Teresa W, Mustakis, Jason, Nelson, Jade D, Olivier, Mark, Peng, Zhihui, Perfect, Hahdi H, Place, David W, Ragan, John A, Salisbury, John J, Stanchina, Corey L, Vanderplas, Brian C, Webster, Mark E, Weekly, R. Matt

“…A practical synthesis of SGLT2 inhibitor candidate ertugliflozin (1) has been developed for potential commercial application. The highly telescoped process…”
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Annulation of Thioimidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (−)-Crambidine by Perl, Nicholas R, Ide, Nathan D, Prajapati, Sudeep, Perfect, Hahdi H, Durón, Sergio G, Gin, David Y

“…A convergent synthesis of (−)-crambidine is reported. The sequence capitalizes on two novel key transformations, including a [4+2] annulation of thioimidates…”
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Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling by Duan, Shengquan, Place, David, Perfect, Hahdi H, Ide, Nathan D, Maloney, Mark, Sutherland, Karen, Price Wiglesworth, Kristin E, Wang, Ke, Olivier, Mark, Kong, Fangming, Leeman, Kyle, Blunt, Jon, Draper, John, McAuliffe, Marie, O’Sullivan, Maria, Lynch, Denis

“…This is the first in a series of three papers describing commercial manufacturing process development for palbociclib (1). This manuscript focuses on the SNAr…”
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Development of a Practical and Convergent Process for the Preparation of Sulopenem by Brenek, Steven J, Caron, Stéphane, Chisowa, Esmort, Delude, Mark P, Drexler, Michele T, Ewing, Marcus D, Handfield, Robert E, Ide, Nathan D, Nadkarni, Durgesh V, Nelson, Jade D, Olivier, Mark, Perfect, Hahdi H, Phillips, James E, Teixeira, John J, Weekly, R. Matt, Zelina, John P

“…Previous synthetic processes for the preparation of sulopenem involved multistep linear sequences in which the chiral sulfoxide side chain was introduced early…”
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Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6) by Chinigo, Gary M., McInturff, Emma L., Bagley, Scott W., Barnhart, Richard W., Blakemore, David C., Han, Lu, Lee, Taegyo, Magano, Javier, McWilliams, J. Christopher, Monfette, Sebastien, Mousseau, James J., Pan, Senliang, Pedro, Dylan, Perfect, Hahdi H., Raggon, Jeffrey W., Rose, Peter R., Sagal, John, Trujillo, John I., Van Haitsma, Jared, Vetelino, Michael G., Yang, Xiaojing Helen

“…The original synthesis of a CCR6 antagonist and subsequent enablement for kilogram manufacture is presented. Highlighted improvements made in the preparation…”
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Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497 by Ashcroft, Christopher P., Berne, Alexander M., Blasberg, Florian, Catlin, Kelly, Collins, Michael R., Critcher, Doug J., Desrosiers, Jean-Nicolas, Goetz, Adam, Hayward, Cheryl, Jones, Ricky A., Karmilowicz, Michael J., Keene, Nandell, Martinez, Carlos A., Monfette, Sebastien, Pattavina, Sebastian David, Perfect, Hahdi H., Ragan, John A., Rauschenberger, Blake, Sach, Neal W., Scotney, Gemma, Sutton, Scott C., Talicska, Courtney, Twiddle, Steven J.R., Haitsma, Jared Van, Wisdom, Richard

“…A cost-efficient approach for the synthesis of a key intermediate of the EZH2 inhibitor PF-06821497 was identified after performing process chemistry…”
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Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated S N Ar Coupling by Duan, Shengquan, Place, David, Perfect, Hahdi H., Ide, Nathan D., Maloney, Mark, Sutherland, Karen, Price Wiglesworth, Kristin E., Wang, Ke, Olivier, Mark, Kong, Fangming, Leeman, Kyle, Blunt, Jon, Draper, John, McAuliffe, Marie, O’Sullivan, Maria, Lynch, Denis

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