The nephrologist's role in metformin-induced lactic acidosis

Metformin is an antihyperglycemic agent commonly used in diabetic patients. It is very effective and is able to reduce the plasma glucose and HbA1C. However, in some patients, specially those with comorbidities, metformin can provoke severe lactic acidosis with high morbimortality. Treatment of the...

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Bibliographic Details
Published in:	Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia Vol. 31; no. 5; p. 587
Main Authors:	Gómez-Navarro, L, de Arriba, G, Sánchez-Heras, M, Pérez del Valle, K M, Hernández-Sevillano, B, Basterrechea, M A, Tallón, S, Torres-Guinea, M, Rodríguez-Palomares, J R
Format:	Journal Article
Language:	English Spanish
Published:	Spain 2011
Subjects:	Acidosis, Lactic - chemically induced Acute Kidney Injury - complications Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antidepressive Agents - therapeutic use Cardiovascular Agents - administration & dosage Cardiovascular Agents - adverse effects Cardiovascular Agents - therapeutic use Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Coma - chemically induced Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Drug Synergism Drug Therapy, Combination Emergencies Fatal Outcome Female Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Ibuprofen - adverse effects Ibuprofen - pharmacology Ibuprofen - therapeutic use Male Metformin - administration & dosage Metformin - adverse effects Metformin - therapeutic use Middle Aged Nephrology Physician's Role Polypharmacy
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Summary:	Metformin is an antihyperglycemic agent commonly used in diabetic patients. It is very effective and is able to reduce the plasma glucose and HbA1C. However, in some patients, specially those with comorbidities, metformin can provoke severe lactic acidosis with high morbimortality. Treatment of the lactic acidosis induced by metformin is based on the use of supportive general measures; in severe cases, procedures of extrarrenal purification like hemodialysis or continuous hemodiafiltration have been successfully used.
ISSN:	1989-2284
DOI:	10.3265/Nefrologia.pre2011.Jun.10955