Subcutaneous versus intravenous administration of trastuzumab: preference of HER2+ breast cancer patients and financial impact of its use

To investigate the preference of HER2+ breast cancer patients and nursing professionals for subcutaneous (SC) versus intravenous (IV) trastuzumab and to evaluate the financial impact derived from the use of the SC formulation. A cross-sectional questionnaire-based study was carried out to investigat...

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Bibliographic Details
Published in:	Journal of B.U. ON. Vol. 22; no. 2; p. 334
Main Authors:	Lazaro Cebas, Andrea, Cortijo Cascajares, Susana, Pablos Bravo, Siria, Del Puy Goyache Goñi, Maria, Gonzalez Monterrubio, Gema, Perez Cardenas, Maria Dolores, Ferrari Piquero, Jose Miguel
Format:	Journal Article
Language:	English
Published:	Greece 01-03-2017
Subjects:	Administration, Intravenous - methods Adult Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cross-Sectional Studies Female Humans Infusions, Intravenous - methods Injections, Subcutaneous - adverse effects Middle Aged Receptor, ErbB-2 - metabolism Trastuzumab - administration & dosage
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Summary:	To investigate the preference of HER2+ breast cancer patients and nursing professionals for subcutaneous (SC) versus intravenous (IV) trastuzumab and to evaluate the financial impact derived from the use of the SC formulation. A cross-sectional questionnaire-based study was carried out to investigate preferences of all patients who started treatment with SC trastuzumab while they had received the IV formulation before. The preference of nursing staff in charge of preparation and administration was also analysed. The financial impact was evaluated considering the number of preparations of SC trastuzumab and the cost of IV and SC trastuzumab, the consumables used for preparation and administration and nursing staff time for preparation. 76 female patients were included, 84% completed the questionnaire. Of the patients, 94% declared to be satisfied with the SC route and 88% would prefer SC administration if they had to choose between IV and SC. Time saving was the main reason to justify satisfaction and preference (48 and 45% respectively). The most common adverse event related to SC trastuzumab was post-injection pain in the injection site, experienced by 77% of the patients. SC trastuzumab was preferred by 100% of the nursing staff. Total annual savings using SC formulation instead of the IV were 35.332€. SC trastuzumab is preferred by patients and the nursing staff versus the IV administration. The use of SC trastuzumab reduced the cost derived from trastuzumab administration.
ISSN:	1107-0625