Search Results - "Perez, Sylvia E."

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease by Moreno-Rodriguez, Marta, Perez, Sylvia E, Nadeem, Muhammad, Malek-Ahmadi, Michael, Mufson, Elliott J

“…Chitinase 3-like 1 (CHI3L1), chitinase 3-like 2 (CHI3L2), and neuronal pentraxin II (NPTX2) are inflammatory biomarkers of Alzheimer's disease (AD). Although…”
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Cholinergic system during the progression of Alzheimer's disease: therapeutic implications by Mufson, Elliott J, Counts, Scott E, Perez, Sylvia E, Ginsberg, Stephen D

“…Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of markers within cholinergic basal forebrain (CBF) neurons, frank CBF…”
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Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease by Mufson, Elliott J, Counts, Scott E, Ginsberg, Stephen D, Mahady, Laura, Perez, Sylvia E, Massa, Stephen M, Longo, Frank M, Ikonomovic, Milos D

“…The current review summarizes the pathobiology of nerve growth factor (NGF) and its cognate receptors during the progression of Alzheimer's disease (AD). Both…”
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Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer’s disease by Perez, Sylvia E., PhD, Nadeem, Muhammad, MD, He, Bin, MD, Miguel, Jennifer C., PhD, Malek-Ahmadi, Michael H, Chen, Kewei, Mufson, Elliott J., PhD

“…Abstract Heterozygous TREM2 mutations are an Alzheimer’s disease (AD) risk factor. Non-mutated TREM2 dysregulation occurs in AD brain. Whether TREM2 is altered…”
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Mild cognitive impairment: pathology and mechanisms by Mufson, Elliott J., Binder, Lester, Counts, Scott E., DeKosky, Steven T., deToledo-Morrell, Leyla, Ginsberg, Stephen D., Ikonomovic, Milos D., Perez, Sylvia E., Scheff, Stephen W.

“…Mild cognitive impairment (MCI) is rapidly becoming one of the most common clinical manifestations affecting the elderly. The pathologic and molecular…”
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Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla) by Perez, Sylvia E., Raghanti, Mary Ann, Hof, Patrick R., Kramer, Lynn, Ikonomovic, Milos D., Lacor, Pascale N., Erwin, Joseph M., Sherwood, Chet C., Mufson, Elliott J.

“…ABSTRACT The two major histopathologic hallmarks of Alzheimer's disease (AD) are amyloid beta protein (Aβ) plaques and neurofibrillary tangles (NFT). Aβ…”
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Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease by Miguel, Jennifer C, Perez, Sylvia E, Malek-Ahmadi, Michael, Mufson, Elliott J

“…Cerebellar hypoplasia is a major characteristic of the Down syndrome (DS) brain. However, the consequences of trisomy upon cerebellar Purkinje cells (PC) and…”
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Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study by Kelley, Christy M, Perez, Sylvia E, Mufson, Elliott J

“…Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative condition associated with repetitive traumatic brain injury (rTBI) seen in…”
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Early Alzheimer's disease–type pathology in the frontal cortex of wild mountain gorillas ( Gorilla beringei beringei ) by Perez, Sylvia E, Sherwood, Chet C, Cranfield, Michael R, Erwin, Joseph M, Mudakikwa, Antoine, Hof, Patrick R, Mufson, Elliott J

“…Abstract Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related…”
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Editorial: Down Syndrome, Neurodegeneration and Dementia by Mufson, Elliott J, Ginsberg, Stephen D, Ma, Tao, Ledreux, Aurélie, Perez, Sylvia E

“…Despite DS being the largest group of individuals with early-onset AD, there is a lack of knowledge defining the mechanisms driving neuronal and functional…”
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Cognitive composite score association with Alzheimer's disease plaque and tangle pathology by Malek-Ahmadi, Michael, Chen, Kewei, Perez, Sylvia E, He, Anna, Mufson, Elliott J

“…Cognitive composite scores are used as the primary outcome measures for Alzheimer's disease (AD) prevention trials; however, the extent to which these…”
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Application of robust regression in translational neuroscience studies with non-Gaussian outcome data by Malek-Ahmadi, Michael, Ginsberg, Stephen D, Alldred, Melissa J, Counts, Scott E, Ikonomovic, Milos D, Abrahamson, Eric E, Perez, Sylvia E, Mufson, Elliott J

“…Linear regression is one of the most used statistical techniques in neuroscience, including the study of the neuropathology of Alzheimer's disease (AD)…”
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Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome by Utagawa, Emma C, Moreno, David G, Schafernak, Kristian T, Arva, Nicoleta C, Malek-Ahmadi, Michael H, Mufson, Elliott J, Perez, Sylvia E

“…Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the…”
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Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice by Perez, Sylvia E, He, Bin, Muhammad, Nadeem, Oh, Kwang-Jin, Fahnestock, Margaret, Ikonomovic, Milos D, Mufson, Elliott J

“…Abstract The cholinotrophic system, which is dependent upon nerve growth factor and its receptors for survival, is selectively vulnerable in Alzheimer's…”
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Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study by Mufson, Elliott J., Perez, Sylvia E., Nadeem, Muhammad, Mahady, Laura, Kanaan, Nicholas M., Abrahamson, Eric E., Ikonomovic, Milos D., Crawford, Fiona, Alvarez, Victor, Stein, Thor, McKee, Ann C.

“…Objective: To test the hypothesis that the nucleus basalis of Meynert (nbM), a cholinergic basal forebrain (CBF) cortical projection system, develops…”
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Exosomes in Vascular/Neurological Disorders and the Road Ahead by Alzahrani, Faisal A, Riza, Yasir M, Eid, Thamir M, Almotairi, Reema, Scherschinski, Lea, Contreras, Jessica, Nadeem, Muhammed, Perez, Sylvia E, Raikwar, Sudhanshu P, Jha, Ruchira M, Preul, Mark C, Ducruet, Andrew F, Lawton, Michael T, Bhatia, Kanchan, Akhter, Naseem, Ahmad, Saif

“…Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke,…”
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Cholinergic forebrain degeneration in the APPswe/PS1ΔE9 transgenic mouse by Perez, Sylvia E, Dar, Saleem, Ikonomovic, Milos D, DeKosky, Steven T, Mufson, Elliott J

“…Abstract The impact of Aβ deposition upon cholinergic intrinsic cortical and striatal, as well as basal forebrain long projection neuronal systems was…”
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Intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xTg mouse model of Alzheimer's disease by Counts, Scott E, Perez, Sylvia E, He, Bin, Mufson, Elliott J

“…Despite recent negative results of the Gammaglobulin Alzheimer's Partnership (GAP) trial, the good tolerability to intravenous immunoglobulin (IVIG) and its…”
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Staging of Alzheimer's Pathology in Triple Transgenic Mice : A Light and Electron Microscopic Analysis by Oh, Kwang-Jin, Perez, Sylvia E., Lagalwar, Sarita, Vana, Laurel, Binder, Lester, Mufson, Elliott J.

“…The age-related pathological cascade underlying intraneuronal tau formation in 3xTg-AD mice, which harbor the human APPSwe, PS1M126V , and TauP301L gene…”
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Braak Stage, Cerebral Amyloid Angiopathy, and Cognitive Decline in Early Alzheimer's Disease by Malek-Ahmadi, Michael, Perez, Sylvia E, Chen, Kewei, Mufson, Elliott J

“…The aim of this study was to determine the interaction between cerebral amyloid angiopathy (CAA) and Braak staging on cognition in the elderly. The study used…”
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