Search Results - "Perez, Carl"

Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules by Gentile, Francesco, Fernandez, Michael, Ban, Fuqiang, Ton, Anh-Tien, Mslati, Hazem, Perez, Carl F, Leblanc, Eric, Yaacoub, Jean Charle, Gleave, James, Stern, Abraham, Wong, Bill, Jean, François, Strynadka, Natalie, Cherkasov, Artem

“…Recent explosive growth of 'make-on-demand' chemical libraries brought unprecedented opportunities but also significant challenges to the field of…”
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Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer by Ton, Anh-Tien, Foo, Jane, Singh, Kriti, Lee, Joseph, Kalyta, Anastasia, Morin, Helene, Perez, Carl, Ban, Fuqiang, Leblanc, Eric, Lallous, Nada, Cherkasov, Artem

“…The Myc family of transcription factors are involved in the development and progression of numerous cancers, including prostate cancer (PCa). Under the…”
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A mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy by Lindenbaum, Michael, Perkins, Ed, Csonka, Erika, Fleming, Elena, Garcia, Lisa, Greene, Amy, Gung, Lindsay, Hadlaczky, Gyula, Lee, Edmond, Leung, Josephine, MacDonald, Neil, Maxwell, Alexisann, Mills, Kathleen, Monteith, Diane, Perez, Carl F., Shellard, Joan, Stewart, Sandy, Stodola, Tom, Vandenborre, Dana, Vanderbyl, Sandy, Ledebur, Harry C.

“…Mammalian artificial chromosomes (MACs) provide a means to introduce large payloads of genetic information into the cell in an autonomously replicating,…”
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Comprehensive Consensus Analysis of SARS-CoV‑2 Drug Repurposing Campaigns by Mslati, Hazem, Gentile, Francesco, Perez, Carl, Cherkasov, Artem

“…The current COVID-19 pandemic has elicited extensive repurposing efforts (both small and large scale) to rapidly identify COVID-19 treatments among approved…”
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Mammalian artificial chromosomes and clinical applications for genetic modification of stem cells: an overview by Katona, Robert L, Vanderbyl, Sandra L, Perez, Carl F

“…Modifying multipotent, self-renewing human stem cells with mammalian artificial chromosomes (MACs), present a promising clinical strategy for numerous…”
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Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells by Vanderbyl, Sandra L., Sullenbarger, Brent, White, Nicole, Perez, Carl F., MacDonald, G. Neil, Stodola, Tom, Bunnell, Bruce A., Ledebur, Harry C., Lasky, Larry C.

“…The transfer of mammalian artificial chromosomes (MACs) to hematopoietic stem and progenitor cells (HSPCs) presents a promising new strategy for ex vivo gene…”
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346. The ACE System, a Mammalian Artificial Chromosome Engineering Technology: Delivery and Transgene Expression in Human Adult & Embryonic Stem Cells by Vanderbyl, Sandra L., Sullenbarger, Brent, MacDonald, Neil, Golembiewski, Melanie, Perez, Carl F., Ledebur Jr, Harry C., Lasky, Larry C.

“…The ACE System is a potent biological engineering system consisting of a mammalian artificial chromosome engineered with multiple site-specific integration…”
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Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection by Co, D O, Borowski, A H, Leung, J D, van der Kaa, J, Hengst, S, Platenburg, G J, Pieper, F R, Perez, C F, Jirik, F R, Drayer, J I

“…We have generated transgenic mice by pronuclear microinjection of a murine satellite DNA-based artificial chromosome (SATAC). As 50% of the founder progeny…”
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Pronuclear microinjection of purified artificial chromosomes for generation of transgenic mice: pick-and-inject technique by Monteith, Diane P, Leung, Josephine D, Borowski, Anita H, Co, Deborah O, Praznovszky, Tünde, Jirik, Frank R, Hadlaczky, Gyula, Perez, Carl F

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Quantitative Structure–Price Relationship (QS$R) Modeling and the Development of Economically Feasible Drug Discovery Projects by Fernandez, Michael, Ban, Fuqiang, Woo, Godwin, Isaev, Oleksandr, Perez, Carl, Fokin, Valery, Tropsha, Alexander, Cherkasov, Artem

“…In recent years, the field of quantitative structure–activity/property relationship (QSAR/QSPR) modeling has developed into a stable technology capable of…”
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Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer by Dalal, Kush, Ban, Fuqiang, Li, Huifang, Morin, Hélène, Roshan-Moniri, Mani, Tam, Kevin J., Shepherd, Ashley, Sharma, Aishwariya, Peacock, James, Carlson, Michael L., LeBlanc, Eric, Perez, Carl, Duong, Franck, Ong, Christopher J., Rennie, Paul S., Cherkasov, Artem

“…Prostate cancer (PCa) is a leading cause of death for men in North America. The androgen receptor (AR) - a hormone inducible transcription factor - drives…”
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Structure-Activity Relationships of Sialyl Lewis x-Containing Oligosaccharides. 1. Effect of Modifications of the Fucose Moiety by Ramphal, John Y, Zheng, Zhong-Li, Perez, Carl, Walker, Leslie E, DeFrees, Shawn A, Gaeta, Federico C. A

“…Leukocyte adhesion to the vasculature is mediated by E-, P-, and L-selectins. The natural ligands for E- and P-selectins have not been fully characterized but…”
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Development of mammalian artificial chromosomes for the treatment of genetic diseases: Sandhoff and Krabbe diseases by Bunnell, Bruce A, Izadpanah, Reza, Ledebur, Jr, Harry C, Perez, Carl F

“…Mammalian artificial chromosomes (MACs) are being developed as alternatives to viral vectors for gene therapy applications, as they allow for the introduction…”
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Stability of a functional murine satellite DNA-based artificial chromosome across mammalian species by Telenius, H, Szeles, A, Keresö, J, Csonka, E, Praznovszky, T, Imreh, S, Maxwell, A, Perez, C F, Drayer, J I, Hadlaczky, G

“…A 60-Mb murine chromosome consisting of murine pericentric satellite DNA and two bands of integrated marker and reporter genes has been generated de novo in a…”
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Should atrial fibrillation be considered a cardiovascular risk factor for a worse prognosis in COVID-19 patients? by Sanchis-Gomar, Fabian, Perez-Quilis, Carme, Lavie, Carl J

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A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact by Perez, C, Albert, I, DeFay, K, Zachariades, N, Gooding, L, Kriegler, M

“…In addition to the induction of tumor regression, tumor necrosis factor (TNF) has been implicated as the causative agent in a number of pathologies, including…”
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Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype by del Guercio, MF, Sidney, J, Hermanson, G, Perez, C, Grey, HM, Kubo, RT, Sette, A

“…Direct MHC binding assays with radiolabeled peptides and HLA class I-expressing mammalian cells such as EBV-transformed B cell lines and PHA-activated blasts…”
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476. Human Mesenchymal Stem Cells Genetically Modified To Express High Levels of Erythropoietin Through Transfer of an Artificial Chromosome Engineered Using the ACE System by Vanderbyl, Sandra, Macdonald, Neil, Stodola, Tom, Telenius, Adele, Stewart, Sandra, Ledebur, Harry C, Perez, Carl F

“…The ACE System is a versatile, reliable system for genetically modifying cell therapies, generating transgenic animals, and engineering mammalian cells for…”
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Transgene Expression after Stable Transfer of a Mammalian Artificial Chromosome into Human Hematopoietic Cells by Vanderbyl, Sandra L., Sullenbarger, Brent, White, Nicole, Perez, Carl F., MacDonald, G. Neil, Stodola, Tom, Bunnell, Bruce, Ledebur, Harry C., Lasky, Larry C.

“…The ACE System, consisting of a pre-engineered mammalian artificial chromosome containing multiple site-specific integration sites (acceptor sites); an ACE…”
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Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-alpha cDNA for the gene therapy of cancer in humans by Hwu, P, Yannelli, J, Kriegler, M, Anderson, WF, Perez, C, Chiang, Y, Schwarz, S, Cowherd, R, Delgado, C, Mule, J

“…TNF is effective in causing the regression of selected murine tumors when administered at high concentrations. Therapeutic levels in humans cannot be obtained…”
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