Search Results - "Perez, Ana I."
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Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration
Published in Frontiers in aging neuroscience (03-05-2017)“…Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/alternatively activated (M2) phenotypes following environmental…”
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Insulin-Like Growth Factor-1 and Neuroinflammation
Published in Frontiers in aging neuroscience (03-11-2017)“…Insulin-like growth factor-1 (IGF-1) effects on aging and neurodegeneration is still controversial. However, it is widely admitted that IGF-1 is involved in…”
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Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19
Published in Clinical science (1979) (12-02-2021)“…The key link between renin-angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-converting enzyme 2), which acts as a double-edged sword, because ACE2…”
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Dopamine-Angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease
Published in Movement disorders (01-09-2013)“…ABSTRACT Renin‐angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between…”
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Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation
Published in Glia (01-03-2015)“…Previous studies have shown that the brain renin–angiotensin system may play a major role, via angiotensin type 1 (AT1) receptors, in the regulation of…”
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A holistic measure of contextual and individual linguistic diversity
Published in International journal of multilingualism (03-04-2023)“…The sociolinguistic context of language use contributes to individuals' linguistic knowledge. However, how it does so has yet to be fully conceptualised or…”
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Brain renin-angiotensin system and dopaminergic cell vulnerability
Published in Frontiers in neuroanatomy (08-07-2014)“…Although the renin-angiotensin system (RAS) was classically considered as a circulating system that regulates blood pressure, many tissues are now known to…”
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The Spanish version of the reflective functioning questionnaire: Validity data in the general population and individuals with personality disorders
Published in PloS one (06-04-2023)“…Mentalization or reflective functioning (RF) is the capacity to interpret oneself or the others in terms of internal mental states. Its failures have been…”
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Microglial TNF-α mediates enhancement of dopaminergic degeneration by brain angiotensin
Published in Glia (01-01-2014)“…In vitro and in vivo models of Parkinson's disease were used to investigate whether TNF‐α plays a major role in the enhancement of the microglial response and…”
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10
Functional, bioactive and antigenicity properties of blue whiting protein hydrolysates: effect of enzymatic treatment and degree of hydrolysis
Published in Journal of the science of food and agriculture (01-01-2017)“…BACKGROUND Fish discards represent an important under‐utilisation of marine resources. This study evaluated the up‐grading of the protein fraction of blue…”
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Statistical Modeling of Dual-Polarized MIMO Land Mobile Satellite Channels
Published in IEEE transactions on communications (01-11-2010)“…This Letter addresses the statistical modeling of dual-polarized MIMO-LMS fading channels. In the absence of accurate experimental results, a statistical model…”
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Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson’s Disease Models
Published in Molecular neurobiology (01-09-2018)“…The exact mechanism of gut dysfunction in Parkinson’s disease and, conversely, the role of gut pathology in brain dopaminergic degeneration are controversial…”
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Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson’s Disease
Published in The Neuroscientist (01-12-2015)“…The small GTP-binding protein Rho plays an important role in several cellular functions. RhoA, which is a member of the Rho family, initiates cellular…”
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Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures
Published in Brain, behavior, and immunity (01-05-2017)“…Graphical abstract…”
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Inflammatory bowel disease induces pathological α‐synuclein aggregation in the human gut and brain
Published in Neuropathology and applied neurobiology (01-02-2024)“…Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain…”
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Interactions between ibuprofen, ACE2, renin‐angiotensin system, and spike protein in the lung. Implications for COVID‐19
Published in Clinical and translational medicine (01-04-2021)“…An increase in ACE2 activity is essential to balance the tissue renin-angiotensin system (RAS) against the inflammatory response (see Figure S1), and several…”
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Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease
Published in Journal of neuroinflammation (22-02-2012)“…Several recent studies have shown that angiotensin type 1 receptor (AT1) antagonists such as candesartan inhibit the microglial inflammatory response and…”
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Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons
Published in Frontiers in immunology (11-11-2024)“…Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes…”
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Menopause and Parkinson’s disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration
Published in Frontiers in neuroendocrinology (01-10-2016)“…[Display omitted] •Estradiol (E2) depletion increases nigral angiotensin system and inflammatory markers.•Inhibition of nigral angiotensin mediates…”
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Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death
Published in Neuropharmacology (01-10-2014)“…Several recent studies have shown that activation of the RhoA/Rho-associated kinase (ROCK) pathway is involved in the MPTP-induced dopaminergic cell…”
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