Search Results - "Pereyra Gerber, Pehuen"

Induction of HIF-1α by HIV-1 Infection in CD4 + T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation by Duette, Gabriel, Pereyra Gerber, Pehuen, Rubione, Julia, Perez, Paula S, Landay, Alan L, Crowe, Suzanne M, Liao, Zhaohao, Witwer, Kenneth W, Holgado, María Pía, Salido, Jimena, Geffner, Jorge, Sued, Omar, Palmer, Clovis S, Ostrowski, Matias

“…Chronic immune activation and inflammation are hallmarks of HIV-1 infection and a major cause of serious non-AIDS events in HIV-1-infected individuals on…”
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A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection by Rubione, Julia, Pérez, Paula S., Czernikier, Alejandro, Duette, Gabriel A., Pereyra Gerber, Federico Pehuen, Salido, Jimena, Fabiano, Martina P., Ghiglione, Yanina, Turk, Gabriela, Laufer, Natalia, Cagnoni, Alejandro J., Pérez Sáez, Juan M., Merlo, Joaquín P., Pascuale, Carla, Stupirski, Juan C., Sued, Omar, Varas-Godoy, Manuel, Lewin, Sharon R., Mariño, Karina V., Rabinovich, Gabriel A., Ostrowski, Matías

“…Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently…”
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XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection by Gerber, Pehuén Pereyra, Donde, Maria J., Matheson, Nicholas J., Taylor, Alexander I.

“…The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and…”
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Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin by Mattera, Vanesa S., Pereyra Gerber, Pehuén, Glisoni, Romina, Ostrowski, Matias, Verstraeten, Sandra V., Pasquini, Juana M., Correale, Jorge D.

“…Previous work by our group has shown the pro‐differentiating effects of apotransferrin (aTf) on oligodendroglial cells in vivo and in vitro. Further studies…”
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Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate by Gerber, Pehuén Pereyra, Cabrini, Mercedes, Jancic, Carolina, Paoletti, Luciana, Banchio, Claudia, von Bilderling, Catalina, Sigaut, Lorena, Pietrasanta, Lía I, Duette, Gabriel, Freed, Eric O, Basile, Genevieve de Saint, Moita, Catarina Ferreira, Moita, Luis Ferreira, Amigorena, Sebastian, Benaroch, Philippe, Geffner, Jorge, Ostrowski, Matías

“…During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds…”
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LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein by Shilts, Jarrod, Crozier, Thomas W M, Teixeira-Silva, Ana, Gabaev, Ildar, Gerber, Pehuén Pereyra, Greenwood, Edward J D, Watson, Samuel James, Ortmann, Brian M, Gawden-Bone, Christian M, Pauzaite, Tekle, Hoffmann, Markus, Nathan, James A, Pöhlmann, Stefan, Matheson, Nicholas J, Lehner, Paul J, Wright, Gavin J

“…The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead…”
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Clusterin protects mature dendritic cells from reactive oxygen species mediated cell death by López Malizia, Alvaro, Merlotti, Antonela, Bonte, Pierre-Emmanuel, Sager, Melina, Arribas De Sandoval, Yago, Goudot, Christel, Erra Díaz, Fernando, Pereyra-Gerber, Pehuén, Ceballos, Ana, Amigorena, Sebastian, Geffner, Jorge, Sabatte, Juan

“…Dendritic cells (DCs) play a key role in the induction of the adaptive immune response. They capture antigens in peripheral tissues and prime naïve T…”
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Histidine-Rich Glycoprotein Inhibits HIV-1 Infection in a pH-Dependent Manner by Dantas, Ezequiel, Erra Díaz, Fernando, Pereyra Gerber, Pehuén, Varese, Augusto, Jerusalinsky, Diana Alicia, Epstein, Alberto L, García Rivello, Hernán J, Del Valle Jaén, Ana, Pandolfi, Julieta B, Ceballos, Ana, Ostrowski, Matias, Sabatté, Juan, Geffner, Jorge

“…Histidine-rich glycoprotein (HRG) is an abundant plasma protein with a multidomain structure, allowing its interaction with many ligands, including…”
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Toll-like receptor 2-independent host innate immune response against an epidemic strain of Streptococcus suis that causes a toxic shock-like syndrome in humans by Lachance, Claude, Segura, Mariela, Gerber, Pehuén Pereyra, Xu, Jianguo, Gottschalk, Marcelo

“…Streptococcus suis is an emerging zoonotic agent causing meningitis and septicemia. Outbreaks in humans in China with atypical cases of streptococcal toxic…”
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Low pH impairs complement-dependent cytotoxicity against IgG-coated target cells by Dantas, Ezequiel, Erra Díaz, Fernando, Pereyra Gerber, Pehuén, Merlotti, Antonela, Varese, Augusto, Ostrowski, Matías, Sabatté, Juan, Geffner, Jorge

“…Local acidosis is a common feature of allergic, vascular, autoimmune, and cancer diseases. However, few studies have addressed the effect of extracellular pH…”
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Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals by Boston, Rebecca H, Guan, Rui, Kalmar, Lajos, Beier, Sina, Horner, Emily C, Beristain-Covarrubias, Nonantzin, Yam-Puc, Juan Carlos, Pereyra Gerber, Pehuén, Faria, Luisa, Kuroshchenkova, Anna, Lindell, Anna E, Blasche, Sonja, Correa-Noguera, Andrea, Elmer, Anne, Saunders, Caroline, Bermperi, Areti, Jose, Sherly, Kingston, Nathalie, Grigoriadou, Sofia, Staples, Emily, Buckland, Matthew S, Lear, Sara, Matheson, Nicholas J, Benes, Vladimir, Parkinson, Christine, Thaventhiran, James Ed, Patil, Kiran R

“…Bidirectional interactions between the immune system and the gut microbiota are key contributors to various physiological functions. Immune-associated diseases…”
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Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles by Touizer, Emma, Alrubayyi, Aljawharah, Ford, Rosemarie, Hussain, Noshin, Gerber, Pehuén Pereyra, Shum, Hiu-Long, Rees-Spear, Chloe, Muir, Luke, Gea-Mallorquí, Ester, Kopycinski, Jakub, Jankovic, Dylan, Jeffery-Smith, Anna, Pinder, Christopher L., Fox, Thomas A., Williams, Ian, Mullender, Claire, Maan, Irfaan, Waters, Laura, Johnson, Margaret, Madge, Sara, Youle, Michael, Barber, Tristan J., Burns, Fiona, Kinloch, Sabine, Rowland-Jones, Sarah, Gilson, Richard, Matheson, Nicholas J., Morris, Emma, Peppa, Dimitra, McCoy, Laura E.

“…We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine…”
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Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response by Jackson, Hannah K., Long, Heather M., Yam‐Puc, Juan Carlos, Palmulli, Roberta, Haigh, Tracey A., Gerber, Pehuén Pereyra, Lee, Jin S., Matheson, Nicholas J., Young, Lesley, Trowsdale, John, Lo, Mathew, Taylor, Graham S., Thaventhiran, James E., Edgar, James R.

“…The COVID‐19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing…”
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Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells by Fischer, Katrin, Lulla, Aleksei, So, Tsz Y, Pereyra-Gerber, Pehuén, Raybould, Matthew I J, Kohler, Timo N, Yam-Puc, Juan Carlos, Kaminski, Tomasz S, Hughes, Robert, Pyeatt, Gwendolyn L, Leiss-Maier, Florian, Brear, Paul, Matheson, Nicholas J, Deane, Charlotte M, Hyvönen, Marko, Thaventhiran, James E D, Hollfelder, Florian

“…Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs;…”
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Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils by Iula, Leonardo, Keitelman, Irene A, Sabbione, Florencia, Fuentes, Federico, Guzman, Mauricio, Galletti, Jeremías Gastón, Gerber, Pehuén Pereyra, Ostrowski, Matías, Geffner, Jorge R, Jancic, Carolina C, Trevani, Analía S

“…Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic…”
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Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity by Garland, Gavin D, Harvey, Robert F, Mulroney, Thomas E, Monti, Mie, Fuller, Stewart, Haigh, Richard, Gerber, Pehuén Pereyra, Barer, Michael R, Matheson, Nicholas J, Willis, Anne E

“…Diagnostic testing continues to be an integral component of the strategy to contain the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) global…”
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A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection by Gerber, Pehuén Pereyra, Duncan, Lidia M, Greenwood, Edward Jd, Marelli, Sara, Naamati, Adi, Teixeira-Silva, Ana, Crozier, Thomas Wm, Gabaev, Ildar, Zhan, Jun R, Mulroney, Thomas E, Horner, Emily C, Doffinger, Rainer, Willis, Anne E, Thaventhiran, James Ed, Protasio, Anna V, Matheson, Nicholas J

“…Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2…”
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High Salt Induces a Delayed Activation of Human Neutrophils by Mazzitelli, Ignacio, Bleichmar, Lucía, Melucci, Claudia, Gerber, Pehuén Pereyra, Toscanini, Agustina, Cuestas, María Luján, Diaz, Fernando Erra, Geffner, Jorge

“…High salt (NaCl) concentrations are found in a number of tissues under physiological and pathological conditions. Here, we analyzed the effects induced by high…”
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Type II interferon gamma is detrimental to the host in Streptococcus suis infections caused by an epidemic strain (164.6) by Lachance, Claude, Segura, Mariela, Pereyra Gerber, Pehuen, Bergman, Eugenia, Lacouture, Sonia, Xu, Jianguo, Gottschalk, Marcelo

“…Abstract S. suis is a major swine pathogen that can be transmitted to humans causing severe symptoms. A large human outbreak was described in China, where…”
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Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease by Bergamaschi, Laura, Mescia, Federica, Turner, Lorinda, Hanson, Aimee L., Kotagiri, Prasanti, Dunmore, Benjamin J., Ruffieux, Hélène, De Sa, Aloka, Huhn, Oisín, Morgan, Michael D., Gerber, Pehuén Pereyra, Wills, Mark R., Baker, Stephen, Calero-Nieto, Fernando J., Doffinger, Rainer, Dougan, Gordon, Elmer, Anne, Goodfellow, Ian G., Gupta, Ravindra K., Hosmillo, Myra, Hunter, Kelvin, Kingston, Nathalie, Lehner, Paul J., Matheson, Nicholas J., Nicholson, Jeremy K., Petrunkina, Anna M., Richardson, Sylvia, Saunders, Caroline, Thaventhiran, James E.D., Toonen, Erik J.M., Weekes, Michael P., Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Bradley, John R., Lyons, Paul A., Smith, Kenneth G.C.

“…The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum…”
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