RISK ASSESSMENT BETWEEN CYP1A1 AND CYP2E1 GENE POLYMORPHISM AND THE OCCURRENCE OF HEPATIC CIRRHOSIS AND HEPATOCELLULAR CARCINOMA

Liver cancer is a common neoplasm, which ranks fifth in incidence and third in mortality worldwide. Studies have shown that polymorphisms in cytochrome P450 genes may contribute to the etiology of complex diseases. Polymorphisms in the genes of this family may alter the expression or function of the...

Full description

Saved in:
Bibliographic Details
Published in:BAG. Journal of basic and applied genetics Vol. 28; p. 94
Main Authors: Agren, C, Biselli-Chicote, PM, Castanhole-Nunes, MMU, Russo, A, Peres, NP, Silva, RCMA, Silva, RF, Pavarino, EC, Goloni-Bertollo, EM
Format: Journal Article
Language:French
Published: Buenos Aires Sociedad Argentina de Genetica 01-01-2017
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liver cancer is a common neoplasm, which ranks fifth in incidence and third in mortality worldwide. Studies have shown that polymorphisms in cytochrome P450 genes may contribute to the etiology of complex diseases. Polymorphisms in the genes of this family may alter the expression or function of the protein and influence the individual levels of detoxification that contribute to the development of liver diseases. The aim was investigate the association between the genetic polymorphisms CYP1A1*2A, CYP1A1*2C, CYP2E1*5B and CYP2E1*6 and the risk of hepatic cirrhosis and hepatocellular carcinoma (HCC). A total of 745 patients (257 patients, 488 controls) were evaluated. Polymorphisms were investigated by PCRRFLP and Real-Time PCR. Characteristics such as gender, age and risk factors were analyzed. The results showed that age ≥ 60 years was associated with HCC (p<0.001) and age ≥ 57 years with cirrhosis (p<0.001). The polymorphisms CYP1A1*2A, CYP1A1*2C, CYP2E1*5B and CYP2E1*6 were not associated with risk of HCC and cirrhosis (p>0.05), as well as with CYP1A1 haplotypes (P>0.05). There was no interaction between polymorphisms and smoking, alcohol consumption and clinical parameters in HCC patients (p>0.05). Hepatitis B (p=0.005) and alpha fetoprotein >500 ng/mL (p=0.018) had association with HCC stages. CYP2E1*5B polymorphism was associated with a reduction in survival in HCC patients (p=0.023). This study concludes that age is associated with the risk of developing HCC and cirrhosis, and CYP2E1*5B polymorphism is associated with reduced survival in HCC patients.
ISSN:1666-0390
1852-6233