Search Results - "Perera, Suchithranga M D C"

Activation of the G‐Protein‐Coupled Receptor Rhodopsin by Water by Chawla, Udeep, Perera, Suchithranga M. D. C., Fried, Steven D. E., Eitel, Anna R., Mertz, Blake, Weerasinghe, Nipuna, Pitman, Michael C., Struts, Andrey V., Brown, Michael F.

“…Visual rhodopsin is an important archetype for G‐protein‐coupled receptors, which are membrane proteins implicated in cellular signal transduction. Herein, we…”
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Small-Angle Neutron Scattering Reveals Energy Landscape for Rhodopsin Photoactivation by Perera, Suchithranga M. D. C, Chawla, Udeep, Shrestha, Utsab R, Bhowmik, Debsindhu, Struts, Andrey V, Qian, Shuo, Chu, Xiang-Qiang, Brown, Michael F

“…Knowledge of the activation principles for G-protein-coupled receptors (GPCRs) is critical to development of new pharmaceuticals. Rhodopsin is the archetype…”
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Powdered G‑Protein-Coupled Receptors by Perera, Suchithranga M. D. C, Chawla, Udeep, Brown, Michael F

“…Preparation and storage of functional membrane proteins such as G-protein-coupled receptors (GPCRs) are crucial to the processes of drug delivery and…”
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Quasi-elastic Neutron Scattering Reveals Ligand-Induced Protein Dynamics of a G‑Protein-Coupled Receptor by Shrestha, Utsab R, Perera, Suchithranga M. D. C, Bhowmik, Debsindhu, Chawla, Udeep, Mamontov, Eugene, Brown, Michael F, Chu, Xiang-Qiang

“…Light activation of the visual G-protein-coupled receptor (GPCR) rhodopsin leads to significant structural fluctuations of the protein embedded within the…”
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Hydration-mediated G-protein-coupled receptor activation by Fried, Steven D E, Hewage, Kushani S K, Eitel, Anna R, Struts, Andrey V, Weerasinghe, Nipuna, Perera, Suchithranga M D C, Brown, Michael F

“…The Rhodopsin family of G-protein–coupled receptors (GPCRs) comprises the targets of nearly a third of all pharmaceuticals. Despite structural water present in…”
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Extent of Internal Hydration influence the Activation of GPCR Rhodopsin by Weerasinghe, Nipuna, Fried, Steven D. E., Struts, Andrey V., Perera, Suchithranga M. D. C., Brown, Michael F.

“…Rhodopsin is an archetypical GPCR responsible for dim‐light vision, which adopts a dynamic equilibrium between two metastable intermediates, metarhodopsin‐I…”
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Osmotic stress studies of G-protein-coupled receptor rhodopsin activation by Struts, Andrey V, Barmasov, Alexander V, Fried, Steven D E, Hewage, Kushani S K, Perera, Suchithranga M D C, Brown, Michael F

“…We summarize and critically review osmotic stress studies of the G-protein-coupled receptor rhodopsin. Although small amounts of structural water are present…”
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Native mass spectrometry reveals the simultaneous binding of lipids and zinc to rhodopsin by Norris, Carolanne E., Keener, James E., Perera, Suchithranga M.D.C., Weerasinghe, Nipuna, Fried, Steven D.E., Resager, William C., Rohrbough, James G., Brown, Michael F., Marty, Michael T.

“…Rhodopsin, a prototypical G-protein-coupled receptor, is responsible for scoptic vision at low-light levels. Although rhodopsin’s photoactivation cascade is…”
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A Usual G-Protein-Coupled Receptor in Unusual Membranes by Chawla, Udeep, Jiang, Yunjiang, Zheng, Wan, Kuang, Liangju, Perera, Suchithranga M. D. C., Pitman, Michael C., Brown, Michael F., Liang, Hongjun

“…G‐protein‐coupled receptors (GPCRs) are the largest family of membrane‐bound receptors and constitute about 50 % of all known drug targets. They offer great…”
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Activation of the G‐Protein‐Coupled Receptor Rhodopsin by Water by Chawla, Udeep, Perera, Suchithranga M. D. C., Fried, Steven D. E., Eitel, Anna R., Mertz, Blake, Weerasinghe, Nipuna, Pitman, Michael C., Struts, Andrey V., Brown, Michael F.

“…Visual rhodopsin is an important archetype for G‐protein‐coupled receptors, which are membrane proteins implicated in cellular signal transduction. Herein, we…”
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Investigation of rhodopsin dynamics in its signaling state by solid-state deuterium NMR spectroscopy by Struts, Andrey V, Chawla, Udeep, Perera, Suchithranga M D C, Brown, Michael F

“…Site-directed deuterium NMR spectroscopy is a valuable tool to study the structural dynamics of biomolecules in cases where solution NMR is inapplicable…”
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A Usual G-Protein-Coupled Receptor in Unusual Membranes by Chawla, Udeep, Jiang, Yunjiang, Zheng, Wan, Kuang, Liangju, Perera, Suchithranga M. D. C., Pitman, Michael C., Brown, Michael F., Liang, Hongjun

“…G‐protein‐coupled receptors (GPCRs) are the largest family of membrane‐bound receptors and constitute about 50 % of all known drug targets. They offer great…”
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Water is a powerful dynamic allosteric modulator in rhodopsin activation by Hewage, Kushani S.K., Fried, Steven D.E., Kadinappulige, Shalini D.S., Struts, Andrey V., Perera, Suchithranga M.D.C., Brown, Michael F.

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Electronic structure calculations and deuterium NMR spectroscopy reveal retinal mobility in rhodopsin activation by Perera, Suchithranga M.D.C., Erly, Andrew, Makara, Anna, Nikolaev, Dmitrii M., Ryazantsev, Mikhail N., Struts, Andrey V., Brown, Michael F.

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X-ray scattering exhibits time-resolved view of rhodopsin activation by Menon, C. Swathi K., Karpos, Konstantinos, Grant, Thomas D., Struts, Andrey V., Fried, Steven D.E., Perera, Suchithranga M.D.C., Kosheleva, Irina V., Salas-Estrada, Leslie, Grossfield, Alan, Fromme, Petra, Kirian, Richard A., Brown, Michael F.

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Femtosecond dynamics of rhodopsin revealed by X-ray laser by Brown, Michael F., Grant, Thomas D., Perera, Suchithranga M.D.C., Salas-Estrada, Leslie, Struts, Andrey V., Karpos, Konstantinos, Chawla, Udeep, Fried, Steven D.E., Menon, C. Swathi K., Weerasinghe, Nipuna, Meza, Domingo, Mendez, Derek, Grossfield, Alan, Fromme, Petra, Kirian, Richard A.

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Small Angle Neutron and X-Ray Scattering Reveal Conformational Differences in Detergents Affecting Rhodopsin Activation by Shrestha, Utsab, Bhowmik, Debsindhu, Perera, Suchithranga M.D.C., Chawla, Udeep, Struts, Andrey V., Graziano, Vito, Qian, Shuo, Heller, William T., Brown, Michael F., Chu, Xiang-Qiang

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