Search Results - "Perera, Rushika M."

The Lysosome as a Regulatory Hub by Perera, Rushika M, Zoncu, Roberto

“…The lysosome has long been viewed as the recycling center of the cell. However, recent discoveries have challenged this simple view and have established a…”
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Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance by Altshuler-Keylin, Svetlana, Shinoda, Kosaku, Hasegawa, Yutaka, Ikeda, Kenji, Hong, Haemin, Kang, Qianqian, Yang, Yangyu, Perera, Rushika M., Debnath, Jayanta, Kajimura, Shingo

“…Beige adipocytes gained much attention as an alternative cellular target in anti-obesity therapy. While recent studies have identified a number of regulatory…”
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Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism by Perera, Rushika M., Stoykova, Svetlana, Nicolay, Brandon N., Ross, Kenneth N., Fitamant, Julien, Boukhali, Myriam, Lengrand, Justine, Deshpande, Vikram, Selig, Martin K., Ferrone, Cristina R., Settleman, Jeff, Stephanopoulos, Gregory, Dyson, Nicholas J., Zoncu, Roberto, Ramaswamy, Sridhar, Haas, Wilhelm, Bardeesy, Nabeel

“…The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic…”
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Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex by Castellano, Brian M., Thelen, Ashley M., Moldavski, Ofer, Feltes, McKenna, van der Welle, Reini E. N., Mydock-McGrane, Laurel, Jiang, Xuntian, van Eijkeren, Robert J, Davis, Oliver B., Louie, Sharon M., Perera, Rushika M., Covey, Douglas F., Nomura, Daniel K., Ory, Daniel S., Zoncu, Roberto

“…The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to…”
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MiT TFE Family of Transcription Factors, Lysosomes, and Cancer by Perera, Rushika M, Di Malta, Chiara, Ballabio, Andrea

“…Cancer cells have an increased demand for energy sources to support accelerated rates of growth. When nutrients become limiting, cancer cells may switch to…”
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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth by Di Malta, Chiara, Siciliano, Diletta, Calcagni, Alessia, Monfregola, Jlenia, Punzi, Simona, Pastore, Nunzia, Eastes, Andrea N., Davis, Oliver, De Cegli, Rossella, Zampelli, Angela, Di Giovannantonio, Luca G., Nusco, Edoardo, Platt, Nick, Guida, Alessandro, Ogmundsdottir, Margret Helga, Lanfrancone, Luisa, Perera, Rushika M., Zoncu, Roberto, Pelicci, Pier Giuseppe, Settembre, Carmine, Ballabio, Andrea

“…The mechanistic target of rapamycin complex 1 (mTORC1) is recruited to the lysosome by Rag guanosine triphosphatases (GTPases) and regulates anabolic pathways…”
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Stromal response to Hedgehog signaling restrains pancreatic cancer progression by Lee, John J, Perera, Rushika M, Wang, Huaijun, Wu, Dai-Chen, Liu, X Shawn, Han, Shiwei, Fitamant, Julien, Jones, Phillip D, Ghanta, Krishna S, Kawano, Sally, Nagle, Julia M, Deshpande, Vikram, Boucher, Yves, Kato, Tomoyo, Chen, James K, Willmann, Jürgen K, Bardeesy, Nabeel, Beachy, Philip A

“…Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical…”
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YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression by Fitamant, Julien, Kottakis, Filippos, Benhamouche, Samira, Tian, Helen S., Chuvin, Nicolas, Parachoniak, Christine A., Nagle, Julia M., Perera, Rushika M., Lapouge, Marjorie, Deshpande, Vikram, Zhu, Andrew X., Lai, Albert, Min, Bosun, Hoshida, Yujin, Avruch, Joseph, Sia, Daniela, Campreciós, Genís, McClatchey, Andrea I., Llovet, Josep M., Morrissey, David, Raj, Lakshmi, Bardeesy, Nabeel

“…Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of…”
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A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes by Zoncu, Roberto, Perera, Rushika M., Balkin, Daniel M., Pirruccello, Michelle, Toomre, Derek, De Camilli, Pietro

“…The recent identification of several novel endocytic compartments has challenged our current understanding of the topological and functional organization of…”
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Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth by Gupta, Suprit, Yano, Julian, Mercier, Vincent, Htwe, Htet Htwe, Shin, Hijai R., Rademaker, Gilles, Cakir, Zeynep, Ituarte, Thomas, Wen, Kwun W., Kim, Grace E., Zoncu, Roberto, Roux, Aurélien, Dawson, David W., Perera, Rushika M.

“…Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their…”
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Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer by Adams, Christina R, Htwe, Htet Htwe, Marsh, Timothy, Wang, Aprilgate L, Montoya, Megan L, Subbaraj, Lakshmipriya, Tward, Aaron D, Bardeesy, Nabeel, Perera, Rushika M

“…Pancreatic ductal adenocarcinoma (PDA) is a heterogeneous disease comprised of a basal-like subtype with mesenchymal gene signatures, undifferentiated…”
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Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages by Perera, Rushika M, Zoncu, Roberto, Lucast, Louise, De Camilli, Pietro, Toomre, Derek

“…Phosphoinositides are thought to play an important role in clathrin-coated pit (CCP) dynamics. Biochemical and structural studies have shown a direct…”
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Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate by Zoncu, Roberto, Perera, Rushika M, Sebastian, Rafael, Nakatsu, Fubito, Chen, Hong, Balla, Tamas, Ayala, Guillermo, Toomre, Derek, De Camilli, Pietro V

“…Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂], a phosphoinositide concentrated predominantly in the plasma membrane, binds endocytic clathrin adaptors,…”
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Ready, Set, Go: The EGF Receptor at the Pancreatic Cancer Starting Line by Perera, Rushika M., Bardeesy, Nabeel

“…Acinar-to-ductal metaplasia (ADM) results from pancreatic injury or KRAS activation, and is an early step in pancreatic cancer progression. In this issue of…”
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inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics by Nakatsu, Fubito, Perera, Rushika M, Lucast, Louise, Zoncu, Roberto, Domin, Jan, Gertler, Frank B, Toomre, Derek, De Camilli, Pietro

“…Phosphatidylinositol (PI) 4,5-bisphosphate (PI(4,5)P₂) and its phosphorylated product PI 3,4,5-triphosphate (PI(3,4,5)P₃) are two major phosphoinositides…”
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Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology by Settembre, Carmine, Perera, Rushika M.

“…Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdown to coordinate programmes for…”
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Built to last: lysosome remodeling and repair in health and disease by Zoncu, Roberto, Perera, Rushika M.

“…Lysosomes play major roles in growth regulation and catabolism and are recognized as critical mediators of cellular remodeling. An emerging theme is how the…”
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Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up by Perera, Rushika M, Bardeesy, Nabeel

“…How do cancer cells escape tightly controlled regulatory circuits that link their proliferation to extracellular nutrient cues? An emerging theme in cancer…”
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Zooming in on the cell biology of disease by Perera, Rushika M

“…Today's cell biology could be considered a fusion of disciplines that blends advanced genetics, molecular biology, biochemistry, and engineering to answer…”
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Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer by Lai, Andrea Z, Cory, Sean, Zhao, Hong, Gigoux, Mathieu, Monast, Anie, Guiot, Marie-Christine, Huang, Sidong, Tofigh, Ali, Thompson, Crista, Naujokas, Monica, Marcus, Victoria A, Bertos, Nicholas, Sehat, Bita, Perera, Rushika M, Bell, Emily S, Page, Brent D G, Gunning, Patrick T, Ferri, Lorenzo E, Hallett, Michael, Park, Morag

“…The Met receptor tyrosine kinase is activated or genetically amplified in some gastric cancers, but resistance to small-molecule inhibitors of Met often…”
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