Search Results - "Perera, R J"

The present state of treatments for articular cartilage defects in the knee by Perera, J R, Gikas, P D, Bentley, G

“…Chondral and osteochondral lesions of the knee are notoriously difficult to treat due to the poor healing capacity of articular cartilage and the hostile…”
Get full text

Shape selective bifacial recognition of double helical DNA by Thadke, Shivaji A., Hridya, V. M., Perera, J. Dinithi R., Gil, Roberto R., Mukherjee, Arnab, Ly, Danith H.

“…An impressive array of antigene approaches has been developed for recognition of double helical DNA over the past three decades; however, few have exploited…”
Get full text

Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation by Economos, Nicholas G, Quijano, Elias, Carufe, Kelly E W, Perera, J Dinithi R, Glazer, Peter M

“…Abstract Despite the rapid and broad implementation of CRISPR-Cas9-based technologies, convenient tools to modulate dose, timing, and precision remain limited…”
Get full text

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs by Moran, Victoria A, Perera, Ranjan J, Khalil, Ahmad M

“…The recent discovery that the human and other mammalian genomes produce thousands of long non-coding RNAs (lncRNAs) raises many fascinating questions. These…”
Get full text

Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington’s Disease by Thadke, Shivaji A, Perera, J. Dinithi R, Hridya, V. M, Bhatt, Kirti, Shaikh, Ashif Y, Hsieh, Wei-Che, Chen, Mengshen, Gayathri, Chakicherla, Gil, Roberto R, Rule, Gordon S, Mukherjee, Arnab, Thornton, Charles A, Ly, Danith H

“…We report the development of a new class of nucleic acid ligands that is comprised of Janus bases and the MPγPNA backbone and is capable of binding rCAG…”
Get full text

Synthesis of (R)- and (S)‑Fmoc-Protected Diethylene Glycol Gamma PNA Monomers with High Optical Purity by Hsieh, Wei-Che, Shaikh, Ashif Y, Perera, J. Dinithi R, Thadke, Shivaji A, Ly, Danith H

“…A robust synthetic route has been developed for preparing optically pure, Fmoc-protected diethylene glycol-containing (R)- and (S)-γPNA monomers. The strategy…”
Get full text

Clinical prospects of long noncoding RNAs as novel biomarkers and therapeutic targets in prostate cancer by Mouraviev, V, Lee, B, Patel, V, Albala, D, Johansen, T E B, Partin, A, Ross, A, Perera, R J

“…Background: The lack of sensitive and specific biomarkers for prostate cancer (PCa) has led to over-diagnosis and overtreatment with uncertain benefit…”
Get full text

A prospective study of a ceramic-on-metal bearing in total hip arthroplasty. Clinical results, metal ion levels and chromosome analysis at two years by Kazi, H A, Perera, J R, Gillott, E, Carroll, F A, Briggs, T W R

“…We prospectively assessed the efficacy of a ceramic-on-metal (CoM) hip bearing with uncemented acetabular and femoral components in which cobalt-chrome…”
Get more information

Peptide nucleic acids and their role in gene regulation and editing by Perera, J. Dinithi R., Carufe, Kelly E. W., Glazer, Peter M.

“…The unique properties of peptide nucleic acid (PNA) makes it a desirable candidate to be used in therapeutic and biotechnological interventions. It has been…”
Get full text

DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid by Oyaghire, Stanley N, Quijano, Elias, Perera, J Dinithi R, Mandl, Hanna K, Saltzman, W Mark, Bahal, Raman, Glazer, Peter M

“…Peptide nucleic acids (PNAs) can target and stimulate recombination reactions in genomic DNA. We have reported that γPNA oligomers possessing the diethylene…”
Get full text

Model-based analysis of student satisfaction in open distance learning by Perera, M. J. R., Abeysekera, N.

“…Student satisfaction in Open Distance Learning (ODL) is a widely researched and admired feature in modern world. There are enormous number of research studies…”
Get full text

Identification of novel PPARγ target genes in primary human adipocytes by Perera, Ranjan J., Marcusson, Eric G., Koo, Seongjoon, Kang, Xiaolin, Kim, Youngsoo, White, Neill, Dean, Nicholas M.

“…Adipogenesis is the process by which undifferentiated precursor cells differentiate into fat laden adipocytes. The nuclear proteins peroxisome…”
Get full text

Cytosine deaminase as a negative selective marker for Arabidopsis by Perera, R.J. (Massachusetts Inst. of Technology, Cambridge, MA (USA). Dept. of Biology), Linard, C.G, Signer, E.R

“…Cytosine deaminase (CD), produced by prokaryotes but not by higher eukaryotes including plants, deaminates cytosine to uracil. The enzyme likewise converts…”
Get full text

Publisher Correction: Shape selective bifacial recognition of double helical DNA by Thadke, Shivaji A., Hridya, V. M., Perera, J. Dinithi R., Gil, Roberto R., Mukherjee, Arnab, Ly, Danith H.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Genetic control of plasmid DNA double-strand gap repair in yeast, Saccharomyces cerevisiae by GLASER, V. M, GLASUNOV, A. V, TEVZADZE, G. G, PERERA, J. R, SHESTAKOV, S. V

“…The repair of double-strand gaps (DSGs) in the plasmid DNA of radiosensitive mutants of Saccharomyces cerevisiae has been analyzed. The proportion of repair…”
Get full text

Prediction of Tidal Elevations at Eastern and Western Coastal Areas of Sri Lanka with Short-term Data by Perera, J. A. R. M., Appuhamy, P. A. D. A. N., Ekanayake, E. M. P.

“…Prediction of tidal heights are increasingly beneficial for multitude of ocean functions such as port development, fishing industry, and safe movement of…”
Get full text

MicroRNA-143 Regulates Adipocyte Differentiation by Esau, Christine, Kang, Xiaolin, Peralta, Eigen, Hanson, Elaine, Marcusson, Eric G, Ravichandran, Lingamanaidu V, Sun, Yingqing, Koo, Seongjoon, Perera, Ranjan J, Jain, Ravi, Dean, Nicholas M, Freier, Susan M, Bennett, C Frank, Lollo, Bridget, Griffey, Richard

“…MicroRNAs (miRNAs) are endogenously expressed 20-24 nucleotide RNAs thought to repress protein translation through binding to a target mRNA ( 1 - 3 ). Only a…”
Get full text

Hereditary diffuse gastric cancer (HDGC): Clinical characteristics of a prospective cohort of HDGC patients with and without CDH1 mutation and patients with sporadic GC by Shah, M. A., Pristyazhnyuk, Y., Jhawer, M., Coombes, S., Harlan, M., Randazzo, J., Perera, R. J., Pascarelli, K. M., Coit, D., Kelsen, D. P.

“…Abstract only 4543 Background: HDGC is an autosomal dominant cancer syndrome associated with early onset diffuse GC. Germline mutations in E-cadherin(CDH1)…”
Get full text

[1.1]Ferrocenophane-1,12-dione as a Precursor of 1,12-Di(cyclopenta-2,4-dienylidene)-[1.1]ferrocenophane, a Doubly Bridged Difulvene by Garabatos-Perera, José Ramon, Wartchow, Rudolf, Butenschön, Holger

“…An improved synthesis of [1.1]ferrocenophane‐1,12‐dione (2) by oxidation of [1.1]ferrocenophane with 2,3‐dichloro‐5,6‐dicyano‐p‐benzoquinone (DDQ) is…”
Get full text

Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs by Sun, Yingqing, Koo, Seongjoon, White, Neill, Peralta, Eigen, Esau, Christine, Dean, Nicholas M., Perera, Ranjan J.

“…MicroRNAs (miRNAs) are believed to play important roles in developmental and other cellular processes by hybridizing to complementary target mRNA transcripts…”
Get full text