Search Results - "Perentesis, J P"

FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach by Daugherty, E C, Zhang, Y, Xiao, Z, Mascia, A E, Sertorio, M, Woo, J, McCann, C, Russell, K J, Sharma, R A, Khuntia, D, Bradley, J D, Simone, 2nd, C B, Breneman, J C, Perentesis, J P

“…FLASH therapy is a treatment technique in which radiation is delivered at ultra-high dose rates (≥ 40 Gy/s). The first-in-human FAST-01 clinical trial…”
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RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia by PERENTESIS, J. P, BHATIA, S, ROBISON, L. L, BOYLE, E, SHAO, Y, SHU, X. Ou, STEINBUCH, M, SATHER, H. N, GAYNON, P, KIFFMEYER, W, ENVALL-FOX, J

“…Activating mutations in the RAS oncogenes are among the most common genetic alterations in human cancers, including patients with acute lymphoblastic leukemia…”
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DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group by Bhatla, D, Gerbing, R B, Alonzo, T A, Mehta, P A, Deal, K, Elliott, J, Meshinchi, S, Geiger, H, Perentesis, J P, Lange, B J, Davies, S M

“…Polymorphisms of DNA repair genes RAD51 and XRCC3 increase susceptibility to acute myeloid leukemia (AML) in adults, an effect enhanced by deletion of the…”
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Autologous stem cell transplantation for high-risk Ewing's sarcoma and other pediatric solid tumors by FRASER, C. J, WEIGEL, B. J, PERENTESIS, J. P, DUSENBERY, K. E, DEFOR, T. E, BAKER, K. S, VERNERIS, M. R

“…The prognosis for many pediatric and young adult patients with solid tumors that have metastasized at the time of diagnosis or have relapsed after therapy…”
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Can Rational Combination of Ultra-high Dose Rate FLASH Radiotherapy with Immunotherapy Provide a Novel Approach to Cancer Treatment? by Zhang, Y., Ding, Z., Perentesis, J.P., Khuntia, D., Pfister, S.X., Sharma, R.A.

“…FLASH radiotherapy (FLASH-RT) delivers radiation treatment at an ultra-high dose rate that is several orders of magnitude higher than current clinical…”
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Glutathione S-Transferase Polymorphisms and Outcome of Chemotherapy in Childhood Acute Myeloid Leukemia by DAVIES, Stella M, ROBISON, Leslie L, BUCKLEY, Jonathan D, TJOA, Tom, WOODS, William G, RADLOFF, Gretchen A, ROSS, Julie A, PERENTESIS, John P

“…Glutathione S-transferase theta (GSTT1) and mu (GSTM1) genes are polymorphic, the genes being absent in approximately 15% and 50% of the population,…”
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Polymorphisms of drug metabolizing enzymes and markers of genotoxicity to identify patients with Hodgkin's lymphoma at risk of treatment‐related complications by Kelly, K. M., Perentesis, J. P.

“…Survivors of childhood Hodgkin's lymphoma (HL) have an increased risk of developing treatment‐related complications, especially second malignant neoplasms, as…”
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Autologous stem cell transplantation for high-risk pediatric solid tumors by PERENTESIS, J. P, KATSANIS, E, DEFOR, T. E, NEGLIA, J. P, RAMSAY, N. K. C

“…Many solid tumors exhibit a steep dose-response to alkylating agents, and autologous stem cell transplantation (ASCT) allows escalation of the chemotherapy…”
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Genomic imprinting of H19 and insulin‐like growth factor‐2 in pediatric germ cell tumors by Ross, Julie A., Schmidt, Peter T., Perentesis, John P., Davies, Stella M.

“…BACKGROUND Insulin‐like growth factor‐2 (IGF2) and H19 are reciprocally imprinted genes on chromosome 11; IGF2 is expressed paternally and H19 is expressed…”
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Induction of apoptosis in multidrug-resistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor by PERENTESIS, J. P, WADDICK, K. G, BENDEL, A. E, SHAO, Y, WARMAN, B. E, CHANDAN-LANGLIE, M, UCKUN, F. M

“…Multiagent chemotherapy regimens fail to cure more than one-half of the patients with acute myeloid leukemia (AML) because of the emergence of dominant…”
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Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin by PHAN, L. D, PERENTESIS, J. P, BODLEY, J. W

“…Protein synthesis elongation factor 2 (EF-2) is the target of the ADP-ribosylating activity of diphtheria toxin which is responsible for cell killing…”
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In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor by PERENTESIS, J. P, GUNTHER, R, EVANS, W. E, UCKUN, F. M, WAURZYNIAK, B, YANISHEVSKI, Y, MYERS, D. E, EK, O, MESSINGER, Y, SHAO, Y, CHELSTROM, L. M, SCHNEIDER, E

“…Acute myeloid leukemia (AML) is the most common form of acute leukemia. Contemporary chemotherapy regimens fail to cure most patients with AML. We have…”
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Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling by Perentesis, J P, Phan, L D, Gleason, W B, LaPorte, D C, Livingston, D M, Bodley, J W

“…The elongation factor 2 (EF-2) genes of the yeast Saccharomyces cerevisiae have been cloned and characterized with the ultimate goal of gaining a better…”
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Protein toxin inhibitors of protein synthesis by Perentesis, J P, Miller, S P, Bodley, J W

“…Two classes of extremely toxic proteins kill eukaryotic cells by covalently modifying unique structural features of components that are essential for protein…”
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Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies by Boyle, E B, Steinbuch, M, Tekautz, T, Gutman, J R, Robison, L L, Perentesis, J P

“…Archival slides are a potentially useful source of DNA for mutation analyses in large population-based studies. However, it is unknown whether specimen age or…”
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Glutathione S-Transferase Polymorphisms in Children with Myeloid Leukemia: A Children’s Cancer Group Study by DAVIES, S. M, ROBISON, L. L, BUCKLEY, J. D, RADLOFF, G. A, ROSS, J. A, PERENTESIS, J. P

“…GSTM1 and GSTT1 are polymorphic genes. Absence of enzyme activity is due to homozygous inherited deletion of the gene, reducing detoxification of carcinogens…”
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Why is age such an important independent prognostic factor in acute lymphoblastic leukemia ? by PERENTESIS, J. P

“…Despite the use of similar intensive chemotherapy regimens, adults with acute lymphoblastic leukemia (ALL) exhibit a strikingly inferior outcome when compared…”
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Expression of Diphtheria Toxin Fragment A and Hormone-Toxin Fusion Proteins in Toxin-Resistant Yeast Mutants by Perentesis, John P., Genbauffe, Francis S., Veldman, Sarah A., Galeotti, Cesira L., Livingston, Dennis M., Bodley, James W., Murphy, John R.

“…Mutants of the eukaryote Saccharomyces cerevisiae, previously selected for resistance to diphtheria toxin, were investigated for their suitability as hosts for…”
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Recombinant fusion toxins directed against the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor by Shao, Y, Warman, B E, Perentesis, J P

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Big Babies and Infant Leukemia: A Role for Insulin-like Growth Factor-1? by Ross, Julie A., Perentesis, John P., Robison, Leslie L., Davies, Stella M.

“…Several epidemiologic studies have demonstrated that high birthweight is associated with an increased risk of infant leukemia; however, the reason for this…”
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