Search Results - "Perelmuter, Vladimir"
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Cortical branched actin determines cell cycle progression
Published in Cell research (01-06-2019)“…The actin cytoskeleton generates and senses forces. Here we report that branched actin networks from the cell cortex depend on ARPC1B-containing Arp2/3…”
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MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins
Published in Journal of cell science (05-09-2018)“…Tumor cell invasion and metastasis formation are the major cause of death in cancer patients. These processes rely on extracellular matrix (ECM) degradation…”
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Heterogeneity of Circulating Tumor Cells in Neoadjuvant Chemotherapy of Breast Cancer
Published in Molecules (Basel, Switzerland) (22-03-2018)“…The biological properties of circulating tumor cells (CTCs), and their dynamics during neoadjuvant chemotherapy are important, both for disease progression…”
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P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration
Published in Journal of cell science (08-11-2019)“…Directional collective cell migration (DCCM) is crucial for morphogenesis and cancer metastasis. P-cadherin (also known as CDH3), which is a cell-cell adhesion…”
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LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer
Published in Asian Pacific journal of cancer prevention : APJCP (01-11-2022)“…High LIMCH1 expression in lung and renal cancer is determined as a favorable prognostic factor. However, prognostic value of LIMCH1 expression in breast cancer…”
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The Association of Integrins β3, β4, and αVβ5 on Exosomes, CTCs and Tumor Cells with Localization of Distant Metastasis in Breast Cancer Patients
Published in International journal of molecular sciences (02-02-2023)“…Integrins are cell adhesion receptors, which play a role in breast cancer invasion, angiogenesis, and metastasis. Moreover, it has been shown that exosomal…”
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Spatial Profile of Tumor Microenvironment in PD-L1-Negative and PD-L1-Positive Triple-Negative Breast Cancer
Published in International journal of molecular sciences (11-01-2023)“…The problem of finding more precise stratification criteria for identifying the cohort of patients who would obtain the maximum benefit from immunotherapy is…”
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Heterogeneous Manifestations of Epithelial-Mesenchymal Plasticity of Circulating Tumor Cells in Breast Cancer Patients
Published in International journal of molecular sciences (02-03-2021)“…To date, there is indisputable evidence of significant CTC heterogeneity in carcinomas, in particular breast cancer. The heterogeneity of CTCs is manifested in…”
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Prognosis of Different Types of Non-Small Cell Lung Cancer Progression: Current State and Perspectives
Published in Cellular physiology and biochemistry (10-03-2021)“…Despite advances in diagnostics and therapy of non-small cell lung cancer (NSCLC), the problem of prognosis and prevention of tumor progression is still highly…”
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The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients
Published in International journal of molecular sciences (22-08-2022)“…Stemness and epithelial–mesenchymal plasticity are widely studied in the circulating tumor cells of breast cancer patients because the roles of both processes…”
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Heterogeneity of Stemlike Circulating Tumor Cells in Invasive Breast Cancer
Published in International journal of molecular sciences (16-04-2020)“…The presence of stem and epithelial-mesenchymal-transition (EMT) features in circulating tumor cells (CTCs) determines their invasiveness, adaptability to the…”
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Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression
Published in Lung cancer (Amsterdam, Netherlands) (01-09-2019)“…•Bronchial premalignant lesions may progress to cancer or regress to normal mucosa.•The progression of bronchial lesions is governed by exo- and endogenous…”
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Parameters of Tumor Microenvironment Determine Effectiveness of Anti-PD-1/PD-L1 Therapy
Published in Biochemistry (Moscow) (01-11-2021)“…Undoubtedly, one of the most promising approaches to the treatment of cancer is creation of the pathogenetically based therapeutic drugs. Researchers from all…”
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Characterization of EpCAM-Positive and EpCAM-Negative Tumor Cells in Early-Stage Breast Cancer
Published in International journal of molecular sciences (16-10-2024)“…Most studies on CTCs have focused on isolating cells that express EpCAM. In this study, we emphasize the presence of EpCAM-negative and EpCAM CTCs, in addition…”
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Single Tumor Cells With Epithelial-Like Morphology Are Associated With Breast Cancer Metastasis
Published in Frontiers in oncology (19-02-2020)“…The identification of tumor cells that can be potential metastatic seeds would reach two key aims-prognosis of metastasis risk and appointment of the optimal…”
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Markers of Cancer Cell Invasion: Are They Good Enough?
Published in Journal of clinical medicine (24-07-2019)“…Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of cancer and the first step towards metastasis. Penetrating to…”
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Integrin-associated transcriptional characteristics of circulating tumor cells in breast cancer patients
Published in PeerJ (San Francisco, CA) (18-01-2024)“…Integrins enable cell communication with the basal membrane and extracellular matrix, activating signaling pathways and facilitating intracellular changes…”
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B Lymphocytes Are a Predictive Marker of Eribulin Response and Overall Survival in Locally Advanced or Metastatic Breast Cancer: A Multicenter, Two-Cohort, Non-Randomized, Open-Label, Retrospective Study
Published in Frontiers in oncology (23-06-2022)“…Triple-negative breast cancer has no specific treatment and unfavorable prognosis. Eribulin is one of the drugs widely used in this cohort of patients. In…”
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Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
Published in Frontiers in oncology (10-11-2021)“…The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi…”
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