Search Results - "Perelman, Sofya S"

Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA by Miller, Jason B., Zhang, Shuyuan, Kos, Petra, Xiong, Hu, Zhou, Kejin, Perelman, Sofya S., Zhu, Hao, Siegwart, Daniel J.

“…CRISPR/Cas is a revolutionary gene editing technology with wide‐ranging utility. The safe, non‐viral delivery of CRISPR/Cas components would greatly improve…”
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Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection by Perelman, Sofya S, Abrams, Michael E, Eitson, Jennifer L, Chen, Didi, Jimenez, Alyssa, Mettlen, Marcel, Schoggins, John W, Alto, Neal M

“…The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less…”
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Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death by Shahi, Ifrah, Llaneras, Cristina N, Perelman, Sofya S, Torres, Victor J, Ratner, Adam J

“…Pore-forming toxins (PFTs) are commonly produced by pathogenic bacteria, and understanding them is key to the development of virulence-targeted therapies…”
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A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB by Liu, Zixu, Mar, Katrina B., Hanners, Natasha W., Perelman, Sofya S., Kanchwala, Mohammed, Xing, Chao, Schoggins, John W., Alto, Neal M.

“…The non-canonical NF-κB signalling cascade is essential for lymphoid organogenesis, B cell maturation, osteoclast differentiation, and inflammation in mammals…”
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Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol by Abrams, Michael E., Johnson, Kristen A., Perelman, Sofya S., Zhang, Li-shu, Endapally, Shreya, Mar, Katrina B., Thompson, Bonne M., McDonald, Jeffrey G., Schoggins, John W., Radhakrishnan, Arun, Alto, Neal M.

“…Cholesterol 25-hydroxylase ( CH25H ) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC…”
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Unlatching of the stem domains in the Staphylococcus aureus pore-forming leukocidin LukAB influences toxin oligomerization by Ilmain, Juliana K., Perelman, Sofya S., Panepinto, Maria C., Irnov, Irnov, Coudray, Nicolas, Samhadaneh, Nora, Pironti, Alejandro, Ueberheide, Beatrix, Ekiert, Damian C., Bhabha, Gira, Torres, Victor J.

“…Staphylococcus aureus (S. aureus) is a serious global pathogen that causes a diverse range of invasive diseases. S. aureus utilizes a family of pore-forming…”
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Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA by Miller, Jason B., Zhang, Shuyuan, Kos, Petra, Xiong, Hu, Zhou, Kejin, Perelman, Sofya S., Zhu, Hao, Siegwart, Daniel J.

“…CRISPR/Cas is a revolutionary gene editing technology with wide‐ranging utility. The safe, non‐viral delivery of CRISPR/Cas components would greatly improve…”
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The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia by Langouët-Astrié, Christophe, Oshima, Kaori, McMurtry, Sarah A., Yang, Yimu, Kwiecinski, Jakub M., LaRivière, Wells B., Kavanaugh, Jeffrey S., Zakharevich, Igor, Hansen, Kirk C., Shi, Deling, Zhang, Fuming, Boguslawski, Kristina M., Perelman, Sofya S., Su, Gouwei, Torres, Victor J., Liu, Jian, Horswill, Alexander R., Schmidt, Eric P.

“…Influenza infection is substantially worsened by the onset of secondary pneumonia caused by bacteria, such as methicillin-resistant Staphylococcus aureus…”
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Genetic variation of staphylococcal LukAB toxin determines receptor tropism by Perelman, Sofya S., James, David B. A., Boguslawski, Kristina M., Nelson, Chase W., Ilmain, Juliana K., Zwack, Erin E., Prescott, Rachel A., Mohamed, Adil, Tam, Kayan, Chan, Rita, Narechania, Apurva, Pawline, Miranda B., Vozhilla, Nikollaq, Moustafa, Ahmed M., Kim, Sang Y., Dittmann, Meike, Ekiert, Damian C., Bhabha, Gira, Shopsin, Bo, Planet, Paul J., Koralov, Sergei B., Torres, Victor J.

“…Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence…”
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A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-[kappa]B by Liu, Zixu, Mar, Katrina B, Hanners, Natasha W, Perelman, Sofya S, Kanchwala, Mohammed, Xing, Chao, Schoggins, John W

“…The non-canonical NF-[kappa]B signalling cascade is essential for lymphoid organogenesis, B cell maturation, osteoclast differentiation, and inflammation in…”
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A NIK-SIX signaling axis controls inflammation by targeted silencing of noncanonical NF-κB by Liu, Zixu, Mar, Katrina B., Hanners, Natasha W., Perelman, Sofya S., Kanchwala, Mohammed, Xing, Chao, Schoggins, John W., Alto, Neal M.

“…The non-canonical NF-κB signaling cascade is essential for lymphoid organogenesis, B-cell maturation, osteoclast differentiation, and inflammation in mammals 1…”
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