Search Results - "Perelman, S"

Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA by Miller, Jason B., Zhang, Shuyuan, Kos, Petra, Xiong, Hu, Zhou, Kejin, Perelman, Sofya S., Zhu, Hao, Siegwart, Daniel J.

“…CRISPR/Cas is a revolutionary gene editing technology with wide‐ranging utility. The safe, non‐viral delivery of CRISPR/Cas components would greatly improve…”
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Severe hyperhomocysteinemia and peripheral neuropathy as side effects of nitrous oxide in two patients with sickle cell disease by Neveu, J., Perelman, S., Suisse, G., Monpoux, F.

“…Nitrous oxide (N2O) is a widely used anesthetic agent. We report two patients with sickle cell disease (SCD) who presented with complications following the use…”
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Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection by Perelman, Sofya S, Abrams, Michael E, Eitson, Jennifer L, Chen, Didi, Jimenez, Alyssa, Mettlen, Marcel, Schoggins, John W, Alto, Neal M

“…The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less…”
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Detecting deception via eyeblink frequency modulation by Perelman, Brandon S

“…To assess the efficacy of using eyeblink frequency modulation to detect deception about a third party, 32 participants were sent on a mission to deliver a…”
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Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death by Shahi, Ifrah, Llaneras, Cristina N, Perelman, Sofya S, Torres, Victor J, Ratner, Adam J

“…Pore-forming toxins (PFTs) are commonly produced by pathogenic bacteria, and understanding them is key to the development of virulence-targeted therapies…”
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Cross-Scale Vegetation Patterns of Flooding Pampa Grasslands by Perelman, S. B., León, R. J. C., Oesterheld, M.

“…1 The spatial pattern of vegetation heterogeneity across different scales may indicate the major environmental controls on vegetation structure, and thus guide…”
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Biosecurity assessment of Argentinian pig farms by Alarcón, L.V., Monterubbianesi, M., Perelman, S., Sanguinetti, H.R., Perfumo, C.J., Mateu, E., Allepuz, A.

“…The pig industry is growing very fast in Argentina with an increasing need for replacement animals, feedstuff and transportation of animals. One of the main…”
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Systemic Oversimplification Limits the Potential for Human-AI Partnership by Metcalfe, Jason S., Perelman, Brandon S., Boothe, David L., Mcdowell, Kaleb

“…The modern world is evolving rapidly, especially with respect to the development and proliferation of increasingly intelligent, artificial intelligence (AI)…”
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OP15.04: Simulator‐based obstetric ultrasound training: a prospective randomised single‐blinded study by Ronzoni, S., Rosen, H., Lee, Y., Gotha, L., Perelman, S., Windrim, R.

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Local and regional long-term diversity changes and biotic homogenization in two temperate grasslands by Puhl, L. E., Perelman, S. B., Batista, W. B., Burkart, S. E., León, R. J. C.

“…Questions: Are there losses in species richness due to extinctions? Is the input of new species lower in environments with strong resource limitation? Is there…”
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Weed and arthropod communities in soyabean as related to crop productivity and land use in the Rolling Pampa, Argentina by DE LA FUENTE, E B, PERELMAN, S, GHERSA, C M

“…de la Fuente EB, Perelman S & Ghersa CM (2010). Weed and arthropod communities in soyabean as related to crop productivity and land use in the Rolling Pampa,…”
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In situ simulation and its effects on patient outcomes: a systematic review by Goldshtein, Daniel, Krensky, Cole, Doshi, Sachin, Perelman, Vsevolod S.

“…BackgroundThe use of in situ simulation has previously been shown to increase confidence, teamwork and practical skills of trained professionals. However, a…”
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A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB by Liu, Zixu, Mar, Katrina B., Hanners, Natasha W., Perelman, Sofya S., Kanchwala, Mohammed, Xing, Chao, Schoggins, John W., Alto, Neal M.

“…The non-canonical NF-κB signalling cascade is essential for lymphoid organogenesis, B cell maturation, osteoclast differentiation, and inflammation in mammals…”
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Achieving Competency in Fiber-Optic Intubation Among Resident Physicians After Higher- Versus Lower-Fidelity Task Training: A Randomized Controlled Study by Melvin, Martina T., Siddiqui, Naveed T., Wild, Evan, Parotto, Matteo, Perelman, Vsevolod S., You-Ten, Kong Eric

“…The high-fidelity ORSIM (Airway Simulation Ltd) and the low-fidelity wooden-block fiber-optic task trainers allow users to familiarize themselves with the…”
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Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA by Miller, Jason B., Zhang, Shuyuan, Kos, Petra, Xiong, Hu, Zhou, Kejin, Perelman, Sofya S., Zhu, Hao, Siegwart, Daniel J.

“…CRISPR/Cas is a revolutionary gene editing technology with wide‐ranging utility. The safe, non‐viral delivery of CRISPR/Cas components would greatly improve…”
Get full text

Sterile versus nonsterile gloves for repair of uncomplicated lacerations in the emergency department: A randomized controlled trial by Perelman, Vsevolod S., Francis, Gregory J., Rutledge, Tim, Foote, John, Martino, Frank, Dranitsaris, George

“…Although sterile technique for laceration management continues to be recommended, studies supporting this practice are lacking. Using clean nonsterile gloves…”
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Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol by Abrams, Michael E., Johnson, Kristen A., Perelman, Sofya S., Zhang, Li-shu, Endapally, Shreya, Mar, Katrina B., Thompson, Bonne M., McDonald, Jeffrey G., Schoggins, John W., Radhakrishnan, Arun, Alto, Neal M.

“…Cholesterol 25-hydroxylase ( CH25H ) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC…”
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Unlatching of the stem domains in the Staphylococcus aureus pore-forming leukocidin LukAB influences toxin oligomerization by Ilmain, Juliana K., Perelman, Sofya S., Panepinto, Maria C., Irnov, Irnov, Coudray, Nicolas, Samhadaneh, Nora, Pironti, Alejandro, Ueberheide, Beatrix, Ekiert, Damian C., Bhabha, Gira, Torres, Victor J.

“…Staphylococcus aureus (S. aureus) is a serious global pathogen that causes a diverse range of invasive diseases. S. aureus utilizes a family of pore-forming…”
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Effects of prior exposure to a visual airway cognitive aid on decision-making in a simulated airway emergency: A randomised controlled study by Zasso, Fabricio B., Perelman, Vsevolod S., Ye, Xiang Y., Melvin, Martina, Wild, Evan, Tavares, Walter, You-Ten, Kong Eric

“…Decision-making deficits in airway emergencies have led to adverse patient outcomes. A cognitive aid would assist clinicians through critical decision-making…”
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The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia by Langouët-Astrié, Christophe, Oshima, Kaori, McMurtry, Sarah A., Yang, Yimu, Kwiecinski, Jakub M., LaRivière, Wells B., Kavanaugh, Jeffrey S., Zakharevich, Igor, Hansen, Kirk C., Shi, Deling, Zhang, Fuming, Boguslawski, Kristina M., Perelman, Sofya S., Su, Gouwei, Torres, Victor J., Liu, Jian, Horswill, Alexander R., Schmidt, Eric P.

“…Influenza infection is substantially worsened by the onset of secondary pneumonia caused by bacteria, such as methicillin-resistant Staphylococcus aureus…”
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