Anti-inflammatory actions of herbal medicines in a model of chronic obstructive pulmonary disease induced by cigarette smoke

[Display omitted] •Therapeutic potential of A. lappa, M. glomerata, P major and E. arvense in COPD.•Synergistic anti-inflammatory and protective effects of herbal extracts in COPD.•Reduced leukocytes influx in bronchoalveolar lavage and lung by herbal administration.•Herbal extracts prevented pulmon...

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Published in:	Biomedicine & pharmacotherapy Vol. 99; pp. 591 - 597
Main Authors:	Possebon, Lucas, de Souza Lima Lebron, Isabella, Furlan da Silva, Ligia, Tagliaferri Paletta, Julia, Glad, Bruna Gabrieli, Sant’Ana, Monielle, Iyomasa-Pilon, Melina Mizusaki, Ribeiro Souza, Helena, de Souza Costa, Sara, Pereira da Silva Rodriguesa, Giselda, Pereira, Maria de Lourdes, de Haro Moreno, Andreia, Girol, Ana Paula
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-03-2018
Subjects:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Bronchoalveolar Lavage Fluid - chemistry COPD Disease Models, Animal Drug Synergism Female gamma-Glutamyltransferase - blood Histopathology Inflammatory mediators Male Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plants, Medicinal - chemistry Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Rats Rats, Wistar Smoke - adverse effects Smoking MCP-1 C G Cm L RPM μL GAMMAGT U/L Histopathology ANOVA AnxAA1 Pg Phytotherapy Vs ML PBS ED-1 DAB Inflammatory mediators IL-1β BAL IL-6 IL-10 S.E.M CS p μm CEUA TNF-α NF-kβ Mg CS+phytotherapics HE COPD Smoking
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Summary:	[Display omitted] •Therapeutic potential of A. lappa, M. glomerata, P major and E. arvense in COPD.•Synergistic anti-inflammatory and protective effects of herbal extracts in COPD.•Reduced leukocytes influx in bronchoalveolar lavage and lung by herbal administration.•Herbal extracts prevented pulmonary congestion and tracheal metaplasia.•Herbal mixture decreased inflammatory mediator levels in plasma and lung. The effects of four medicinal herbs (Arctium lappa, Plantago major, Mikania glomerata Spreng and Equisetum arvense) with anti-inflammatory properties were evaluated in a chronic obstructive pulmonary disease (COPD) model. Wistar rats were exposed to cigarette smoke during 8 weeks and one of the groups was orally given a solution containing 4% of each alcoholic herbal extracts during the exposure period. Control group was not exposed to smoke or treated. Histopathological, immunohistochemical and biochemical analyzes were performed. Normal blood plasma levels of gamma glutamyl transferase indicated no toxicity of the administered herbal extracts. The treatment reduced leukocytes influx in bronchoalveolar lavage, mast cell and macrophages numbers in lungs, as well as prevented pulmonary congestion and tracheal metaplasia. Herbal mixture also decreased plasma inflammatory mediator levels and pulmonary expression of annexin A1 and nuclear factor-kβ. Our data indicate synergistic and protective effects of the used herbal medicines in animals exposed to cigarette smoke as a potential therapeutic strategy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2018.01.106