Efficacy of two endectoparasiticide products combining fipronil and (S)-methoprene or esafoxolaner with eprinomectin and praziquantel against fleas and intestinal helminths in cats naturally infested in Brazil

Eprinomectin and praziquantel, nematodicide and cestodicide compounds, are both combined with the insecticide and acaricide compounds fipronil and (S)-methoprene in Frontline Protect/Broadline , or esafoxolaner in NexGard Combo. These topical feline endectoparasiticide products were tested for effic...

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Bibliographic Details
Published in:	Parasite (Paris) Vol. 29; p. 12
Main Authors:	Cutolo, Andre A, Jardina, Debora T G, De Vito, Gabriela G, Grisi do Nascimento, Cristiano, Heidmann, Maycon Junior, Ferreira Nantes, José Dirceu, Bassetto, Karolyne Vieira, Chagas, Isabella Cristina, Pereira Junior, Edgar Ferreira, de Castro, Bruno Gomes, Tielemans, Eric
Format:	Journal Article
Language:	English
Published:	France EDP Sciences 2022
Subjects:	Acaricides Animals Brazil cat Cat Diseases - drug therapy Cats Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet Dipylidium caninum Domestic animals Ectoparasites efficacy Fipronil flea Flea Infestations - drug therapy Flea Infestations - veterinary frontline® protect/broadline Insecticides Insecticides - therapeutic use intestinal helminth Intestine Ivermectin - analogs & derivatives Ivermectin - therapeutic use Methoprene Methoprene - therapeutic use nexgard® combo Parasites Pesticides Praziquantel Praziquantel - therapeutic use Pyrazoles Siphonaptera Special Issue – NexGard Terrain Toxocara Treatment Outcome Brazil Efficacy NexGard® Combo Intestinal helminth Flea Frontline® Protect/Broadline Cat
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Summary:	Eprinomectin and praziquantel, nematodicide and cestodicide compounds, are both combined with the insecticide and acaricide compounds fipronil and (S)-methoprene in Frontline Protect/Broadline , or esafoxolaner in NexGard Combo. These topical feline endectoparasiticide products were tested for efficacy against fleas and intestinal helminths in a field trial in Brazil. Flea- and/or helminth-infested domestic cats were treated twice at a monthly interval following label instructions: 160 cats with Frontline Protect/Broadline and 165 cats with NexGard Combo. The flea and intestinal helminth infestations were evaluated using comb counts and copromicroscopy, respectively before first treatment for baseline value, then 9 and 30 days after each treatment for fleas, and 9 days after each treatment for helminths. Multiparasitism was very frequent at baseline, as amongst the 325 included cats, 295, 280, 86 and 93 cats were at least infested with Ctenocephalides fleas, Ancylostoma, Toxocara and Dipylidium caninum, respectively. Efficacies were calculated by comparing the geometric means at baseline and at post-treatment timepoints for each parasite genus/species. Inclusive of both products and of all evaluation timepoints, the Ctenocephalides, Ancylostoma, Toxocara and D. caninum efficacies were at least 98.3%, 99.8%, 99.8% and 96.3%, respectively. No adverse reactions were observed, except for a few instances of mild, transient, and self-resolving hypersalivation occurring on the day of treatment in both groups. This field trial demonstrated high-level efficacy of Frontline Protect/Broadline and NexGard Combo against major parasites of cats in Brazil.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1776-1042 1252-607X 1776-1042
DOI:	10.1051/parasite/2022012