Search Results - "Pereira, Sandro L"

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state by Smajić, Semra, Prada-Medina, Cesar A, Landoulsi, Zied, Ghelfi, Jenny, Delcambre, Sylvie, Dietrich, Carola, Jarazo, Javier, Henck, Jana, Balachandran, Saranya, Pachchek, Sinthuja, Morris, Christopher M, Antony, Paul, Timmermann, Bernd, Sauer, Sascha, Pereira, Sandro L, Schwamborn, Jens C, May, Patrick, Grünewald, Anne, Spielmann, Malte

“…Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, but the exact disease aetiology remains largely unknown. To…”
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Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective by Mulica, Patrycja, Grünewald, Anne, Pereira, Sandro L

“…Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative…”
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Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism by Borsche, Max, König, Inke R, Delcambre, Sylvie, Petrucci, Simona, Balck, Alexander, Brüggemann, Norbert, Zimprich, Alexander, Wasner, Kobi, Pereira, Sandro L, Avenali, Micol, Deuschle, Christian, Badanjak, Katja, Ghelfi, Jenny, Gasser, Thomas, Kasten, Meike, Rosenstiel, Philip, Lohmann, Katja, Brockmann, Kathrin, Valente, Enza Maria, Youle, Richard J, Grünewald, Anne, Klein, Christine

“…There is increasing evidence for a role of inflammation in Parkinson's disease. Recent research in murine models suggests that parkin and PINK1 deficiency…”
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PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation by Lind-Holm Mogensen, Frida, Sousa, Carole, Ameli, Corrado, Badanjak, Katja, Pereira, Sandro L, Muller, Arnaud, Kaoma, Tony, Coowar, Djalil, Scafidi, Andrea, Poovathingal, Suresh K, Tziortziou, Maria, Antony, Paul M A, Nicot, Nathalie, Ginolhac, Aurélien, Vogt Weisenhorn, Daniela M, Wurst, Wolfgang, Poli, Aurélie, Nazarov, Petr V, Skupin, Alexander, Grünewald, Anne, Michelucci, Alessandro

“…Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson's disease (PD)…”
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Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency by Rodrigues, Ana Sofia, Correia, Marcelo, Gomes, Andreia, Pereira, Sandro L, Perestrelo, Tânia, Sousa, Maria Inês, Ramalho-Santos, João

“…The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and…”
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Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency by Pereira, Sandro L, Grãos, Mário, Rodrigues, Ana Sofia, Anjo, Sandra I, Carvalho, Rui A, Oliveira, Paulo J, Arenas, Ernest, Ramalho-Santos, João

“…The mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we…”
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Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept by Lüth, Theresa, Wasner, Kobi, Klein, Christine, Schaake, Susen, Tse, Ronnie, Pereira, Sandro L, Laß, Joshua, Sinkkonen, Lasse, Grünewald, Anne, Trinh, Joanne

“…To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected…”
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Mitochondrial Mechanisms of LRRK2 G2019S Penetrance by Delcambre, Sylvie, Ghelfi, Jenny, Ouzren, Nassima, Grandmougin, Léa, Delbrouck, Catherine, Seibler, Philip, Wasner, Kobi, Aasly, Jan O., Klein, Christine, Trinh, Joanne, Pereira, Sandro L., Grünewald, Anne

“…Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes…”
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Comparison of two protocols for the generation of iPSC-derived human astrocytes by Mulica, Patrycja, Venegas, Carmen, Landoulsi, Zied, Badanjak, Katja, Delcambre, Sylvie, Tziortziou, Maria, Hezzaz, Soraya, Ghelfi, Jenny, Smajic, Semra, Schwamborn, Jens, Krüger, Rejko, Antony, Paul, May, Patrick, Glaab, Enrico, Grünewald, Anne, Pereira, Sandro L

“…Abstract Background Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including Parkinson’s…”
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Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells by Rodrigues, Ana Sofia, Pereira, Sandro L, Correia, Marcelo, Gomes, Andreia, Perestrelo, Tânia, Ramalho-Santos, João

“…Pluripotent embryonic stem cells grown under standard conditions (ESC) have a markedly glycolytic profile, which is shared with many different types of cancer…”
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iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease by Badanjak, Katja, Mulica, Patrycja, Smajic, Semra, Delcambre, Sylvie, Tranchevent, Leon-Charles, Diederich, Nico, Rauen, Thomas, Schwamborn, Jens C, Glaab, Enrico, Cowley, Sally A, Antony, Paul M A, Pereira, Sandro L, Venegas, Carmen, Grünewald, Anne

“…Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the majority of patients, who are therefore considered "idiopathic" (IPD). PD…”
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Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity by Scafidi, Andrea, Lind-Holm Mogensen, Frida, Campus, Eleonora, Pailas, Alexandros, Neumann, Katrin, Legrave, Nathalie, Bernardin, François, Pereira, Sandro L., Antony, Paul M.A., Nicot, Nathalie, Mittelbronn, Michel, Grünewald, Anne, Nazarov, Petr V., Poli, Aurélie, Van Dyck, Eric, Michelucci, Alessandro

“…Epidemiological studies suggest that metformin reduces the risk of developing several types of cancer, including gliomas, and improves the overall survival in…”
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Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions by Pereira, Gonçalo C, Branco, Ana F, Matos, Júlio A C, Pereira, Sandro L, Parke, Donna, Perkins, Edward L, Serafim, Teresa L, Sardão, Vilma A, Santos, Maria S, Moreno, Antonio J M, Holy, Jon, Oliveira, Paulo J

“…Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium] is an alkaloid present in plant extracts and has a…”
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Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease by Pereira, Sandro L., Grossmann, Dajana, Delcambre, Sylvie, Hermann, Andreas, Grünewald, Anne

“…Mutations in PRKN cause the second most common genetic form of Parkinson's disease (PD)—a debilitating movement disorder that is on the rise due to population…”
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Metabolic Remodeling During H9c2 Myoblast Differentiation: Relevance for In Vitro Toxicity Studies by Pereira, Sandro L., Ramalho-Santos, João, Branco, Ana F., Sardão, Vilma A., Oliveira, Paulo J., Carvalho, Rui A.

“…H9c2 cells, derived from the ventricular part of an E13 BDIX rat heart, possess a proliferative and relatively undifferentiated phenotype but can be readily…”
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Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation by Wasner, Kobi, Smajic, Semra, Ghelfi, Jenny, Delcambre, Sylvie, Prada‐Medina, Cesar A., Knappe, Evelyn, Arena, Giuseppe, Mulica, Patrycja, Agyeah, Gideon, Rakovic, Aleksandar, Boussaad, Ibrahim, Badanjak, Katja, Ohnmacht, Jochen, Gérardy, Jean‐Jacques, Takanashi, Masashi, Trinh, Joanne, Mittelbronn, Michel, Hattori, Nobutaka, Klein, Christine, Antony, Paul, Seibler, Philip, Spielmann, Malte, Pereira, Sandro L., Grünewald, Anne

“…ABSTRACT Background Mutations in the E3 ubiquitin ligase parkin cause autosomal recessive Parkinson's disease (PD). Together with PTEN‐induced kinase 1…”
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Data on the potential impact of food supplements on the growth of mouse embryonic stem cells by Correia, Marcelo, Sousa, Maria I., Rodrigues, Ana S., Perestrelo, Tânia, Pereira, Sandro L., Ribeiro, Marcelo F., Ramalho-Santos, João

“…The use of new compounds as dietary supplements is increasing, but little is known in terms of possible consequences of their use. Pluripotent stem cells are a…”
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Sirtuins in metabolism, stemness and differentiation by Correia, Marcelo, Perestrelo, Tânia, Rodrigues, Ana S., Ribeiro, Marcelo F., Pereira, Sandro L., Sousa, Maria I., Ramalho-Santos, João

“…Pluripotent stem cells promise innovative approaches for enduring diseases, including disease modeling and drug screens. Accordingly, efforts have been…”
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From gametogenesis and stem cells to cancer: common metabolic themes by Pereira, Sandro L, Rodrigues, Ana Sofia, Sousa, Maria Inês, Correia, Marcelo, Perestrelo, Tânia, Ramalho-Santos, João

“…Both pluripotent stem cells (PSCs) and cancer cells have been described as having similar metabolic pathways, most notably a penchant for favoring glycolysis…”
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Different concentrations of kaempferol distinctly modulate murine embryonic stem cell function by Correia, Marcelo, Rodrigues, Ana S., Perestrelo, Tânia, Pereira, Sandro L., Ribeiro, Marcelo F., Sousa, Maria I., Ramalho-Santos, João

“…Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonoid with several beneficial and protective effects. It has been demonstrated that kaempferol has…”
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