Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS study

To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples. Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV. A total of 1,081 HC2 tests for HR-HPV...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of gynaecological oncology Vol. 29; no. 4; p. 327
Main Authors:	Longatto-Filho, A, Roteli-Martins, C, Hammes, L, Etlinger, D, Pereira, S M Miranda, Erzen, M, Branca, M, Naud, P, Derchain, S F M, Sarian, L O, Matos, J, Gontijo, R, Lima, T, Maeda, M Y S, Tatti, S, Syrjänen, S, Syrjänen, K
Format:	Journal Article
Language:	English
Published:	Italy 2008
Subjects:	Adult Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - prevention & control Cervical Intraepithelial Neoplasia - virology Cohort Studies Female Humans Latin America Mass Screening - methods Middle Aged Papanicolaou Test Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - diagnosis Papillomavirus Infections - virology Predictive Value of Tests Prevalence Prospective Studies Reagent Kits, Diagnostic Self-Examination - methods Sensitivity and Specificity Specimen Handling Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - prevention & control Uterine Cervical Neoplasms - virology Vaginal Smears - methods Latin America
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples. Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV. A total of 1,081 HC2 tests for HR-HPV were performed: 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved: 92.9% and 62.5%, respectively. HC2 specificity for any cervical lesion and for CIN2 or higher were close to 90% in both groups. Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.
ISSN:	0392-2936