Search Results - "Pereira, Mirian Claudia DE Souza"
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Acute Chagas disease induces cerebral microvasculopathy in mice
Published in PLoS neglected tropical diseases (01-07-2014)“…Cardiomyopathy is the main clinical form of Chagas disease (CD); however, cerebral manifestations, such as meningoencephalitis, ischemic stroke and cognitive…”
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Differential Role of TGF-β in Extracellular Matrix Regulation During Trypanosoma cruzi -Host Cell Interaction
Published in International journal of molecular sciences (29-09-2019)“…Transforming growth factor beta (TGF-β) is a determinant for inflammation and fibrosis in cardiac and skeletal muscle in Chagas disease. To determine its…”
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Synthesis by Microwave Irradiation, Molecular Structural Analysis and Trypanocidal Activity of Novel Pyrazole-tetrahydropyrimidine Derivatives
Published in Current organic synthesis (01-01-2023)“…A series of new eight 2-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1,4,5,6-tetrahydropyrimidines 1(a-h) were synthesized by microwave irradiation technique. In vitro…”
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4
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins
Published in Parasites & vectors (30-01-2018)“…Cardiac fibrosis is a consequence of chronic chagasic cardiomyopathy (CCC). In other cardiovascular diseases, the protagonist role of fibroblasts in cardiac…”
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Insights into the tracking of the cysteine proteinase B COOH-terminal polypeptide of Leishmania (Leishmania) amazonensis by surface plasmon resonance
Published in Parasitology research (1987) (01-04-2019)“…Leishmania ( Leishmania ) amazonensis has adaptive mechanisms to the host environment that are guided by its proteinases, including cysteine proteinase B…”
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Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi
Published in International journal for parasitology -- drugs and drug resistance (01-12-2016)“…Chagas disease is a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. The current drugs used to treat this disease have limited…”
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Synthesis and Anti- Trypanosoma cruzi Activity of New Pyrazole-Thiadiazole Scaffolds
Published in Molecules (Basel, Switzerland) (01-08-2024)“…Chagas disease, a silent but widespread disease that mainly affects a socioeconomically vulnerable population, lacks innovative safe drug therapy. The…”
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Impact of collaborative actions of Leishmania (Viannia) braziliensis subpopulations on the infection profile
Published in Parasitology (01-10-2022)“…This study focuses on the role of the population structure of Leishmania spp. on the adaptive capacity of the parasite. Herein, we investigate the contribution…”
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9
Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection
Published in Memórias do Instituto Oswaldo Cruz (01-01-2022)“…Angiogenesis has been implicated in tissue injury in several noninfectious diseases, but its role in Chagas disease (CD) physiopathology is unclear. The…”
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In the Acute Phase of Trypanosoma cruzi Infection, Liver Lymphoid and Myeloid Cells Display an Ambiguous Phenotype Combining Pro- and Anti-Inflammatory Markers
Published in Frontiers in immunology (26-05-2022)“…Multiple cell populations, cellular biochemical pathways, and the autonomic nervous system contribute to maintaining the immunological tolerance in the liver…”
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Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models
Published in Biology (Basel, Switzerland) (01-09-2023)“…Chagas disease therapy still relies on two nitroderivatives, nifurtimox and benznidazole (Bz), which have important limitations and serious adverse effects…”
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12
Detection of matrix metallopeptidase-9-like proteins in Trypanosoma cruzi
Published in Experimental parasitology (01-07-2010)“…In this study, the cell-associated and extracellular peptidases of Trypanosoma cruzi grown in modified Roitman’s complex (MRC) medium were analyzed by…”
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4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
Published in PLoS neglected tropical diseases (27-12-2017)“…Chagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is…”
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Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against Trypanosoma cruzi : Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease
Published in Pharmaceutics (05-05-2022)“…Chagas disease, a century-old disease that mainly affects the impoverished population in Latin America, causes high morbidity and mortality in endemic…”
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Trypanosoma janseni n. sp. (Trypanosomatida: Trypanosomatidae) isolated from Didelphis aurita (Mammalia: Didelphidae) in the Atlantic Rainforest of Rio de Janeiro, Brazil: integrative taxonomy and phylogeography within the Trypanosoma cruzi clade
Published in Memórias do Instituto Oswaldo Cruz (01-01-2018)“…Didelphis spp. are a South American marsupial species that are among the most ancient hosts for the Trypanosoma spp. We characterise a new species (Trypanosoma…”
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Natural products from marine red and brown algae against Trypanosoma cruzi
Published in Revista brasileira de farmacognosia (01-11-2019)“…[Display omitted] Various extracts obtained from the red alga Plocamium brasiliense (Greville Howe & Taylor), including a fraction containing crude…”
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Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2'-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment
Published in Molecules (Basel, Switzerland) (10-04-2018)“…Epoxymethoxylawsone is a naphthoquinone derivative promising as drug candidate for the treatment of leishmaniases. In the present work the effectiveness of…”
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18
Leishmania major: Parasite interactions suggesting sexuality
Published in Memórias do Instituto Oswaldo Cruz (01-11-1997)“…In five experiments, Leishmania (Leishmania) major (MRHO/SU/59/P-strain) grew poorly when seeded in FYTS medium supplemented with 15% fetal calf serum, but…”
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TGF-β receptor type II costameric localization in cardiomyocytes and host cell TGF-β response is disrupted by Trypanosoma cruzi infection
Published in Parasitology (01-05-2016)“…Transforming growth factor beta (TGF-β) cytokine is involved in Chagas disease establishment and progression. Since Trypanosoma cruzi can modulate host cell…”
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Trypanosoma cruzi heparin-binding proteins and the nature of the host cell heparan sulfate-binding domain
Published in Microbial pathogenesis (01-04-2008)“…Trypanosoma cruzi invasion is mediated by receptor–ligand recognition between the surfaces of both parasite and target cell. We have previously demonstrated…”
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