Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients

Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients

Background In patients with colorectal cancer, involvement of the lymph nodes is one of the most important prognostic factors. The aim of this study was to determine the independent prognostic value of the lymph node ratio (LNR), that is the relationship between the involved and examined lymph nodes...

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Published in:Techniques in coloproctology Vol. 13; no. 2; pp. 113 - 121
Main Authors: Priolli, D. G., Cardinalli, I. Aparecida, Pereira, J. Aires, Alfredo, C. Helaehil, Margarido, N. Fontana, Martinez, C. A. Real
Format: Journal Article
Language:English
Published: Milan Springer Milan 01-06-2009
Springer Nature B.V
Subjects:
Abdominal Surgery
Adenocarcinoma - mortality
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Cohort Studies
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Colorectal Surgery
Female
Gastroenterology
Humans
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Original Article
Predictive Value of Tests
Proctology
Reproducibility of Results
Retrospective Studies
Surgery
Survival Rate
Survival analysis
Prognosis
Colorectal neoplasms
Survival rate
Lymph nodes
Lymph node excision
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Summary:Background In patients with colorectal cancer, involvement of the lymph nodes is one of the most important prognostic factors. The aim of this study was to determine the independent prognostic value of the lymph node ratio (LNR), that is the relationship between the involved and examined lymph nodes, in patients with colorectal cancer. Methods Included in the study were 113 patients with colorectal adenocarcinoma. The patients were divided into three groups according to the proportion of involved lymph nodes: LNR-0, when there was no lymph node involvement; LNR-1, when there was involvement of up to 20% of the examined lymph nodes, and LNR-2, when there was involvement of 21% or more of the examined nodes. The relationship between lymph node ratio, the number of lymph nodes removed, and the number of lymph nodes involved by cancer was determined. The 5-year survival was evaluated using the Kaplan-Meier test. Results There was a significant difference in 5-year overall between patients in the different LNR groups ( p =0.009). Patients in the LNR-0 group had a 5-year overall survival greater than 80%, while those in the LNR-1 and LNR-2 groups had 5-year overall survival rates less than 60% and 40%, respectively. Multivariate analysis demonstrated that the LNR is an independent prognostic variable in 5-year overall survival ( p =0.009). Conclusion The results showed that the LNR can be considered an independent prognostic variable in overall survival of patients with colorectal cancer.
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ISSN:1123-6337
1128-045X
DOI:10.1007/s10151-009-0467-5