Search Results - "Pereira, Humberto"

X-ray structure of the metastable SEPT14-SEPT7 coiled coil reveals a hendecad region crucial for heterodimerization by Cavini, Italo A, Winter, Ashley J, D'Muniz Pereira, Humberto, Woolfson, Derek N, Crump, Matthew P, Garratt, Richard C

“…Septins are membrane-associated, GTP-binding proteins that are present in most eukaryotes. They polymerize to play important roles as scaffolds and/or…”
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Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease by Godoy, Andre Schutzer, Nakamura, Aline Minalli, Douangamath, Alice, Song, Yun, Noske, Gabriela Dias, Gawriljuk, Victor Oliveira, Fernandes, Rafaela Sachetto, Pereira, Humberto D Muniz, Oliveira, Ketllyn Irene Zagato, Fearon, Daren, Dias, Alexandre, Krojer, Tobias, Fairhead, Michael, Powell, Alisa, Dunnet, Louise, Brandao-Neto, Jose, Skyner, Rachael, Chalk, Rod, Bajusz, Dávid, Bege, Miklós, Borbás, Anikó, Keserű, György Miklós, von Delft, Frank, Oliva, Glaucius

“…Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The NSP15 endoribonuclease…”
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Structural Characterization of L-Galactose Dehydrogenase: An Essential Enzyme for Vitamin C Biosynthesis by Vargas, Jhon A, Leonardo, Diego A, D’Muniz Pereira, Humberto, Lopes, Adriana R, Rodriguez, Hicler N, Cobos, Marianela, Marapara, Jorge L, Castro, Juan C, Garratt, Richard C

“…Abstract In plants, it is well-known that ascorbic acid (vitamin C) can be synthesized via multiple metabolic pathways but there is still much to be learned…”
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Structural insights into the Smirnoff-Wheeler pathway for vitamin C production in the Amazon fruit Camu-Camu by Vargas, Jhon A, Sculaccio, Susana A, Pinto, Andressa P A, Pereira, Humberto D'Muniz, Mendes, Luis F S, Flores, Jhoao F, Cobos, Marianela, Castro, Juan C, Garratt, Richard C, Leonardo, Diego A

“…L-Ascorbic acid (AsA, vitamin C) is a pivotal dietary nutrient with multifaceted importance in living organisms. In plants, the Smirnoff-Wheeler (SW) pathway…”
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Structural and thermodynamic characterization of a highly amyloidogenic dimer of transthyretin involved in a severe cardiomyopathy by Martins, Lucas do Amaral, Ferreira, Priscila S., Leitão dos Santos, Otávio Augusto, Martins, Leticia Oliveira, Cabral Fernandes Barroso, Luiz Gabriel, Pereira, Humberto M., Waddington-Cruz, Márcia, Palhano, Fernando Lucas, Foguel, Debora

“…Transthyretin (TTR) is an homotetrameric protein involved in the transport of thyroxine. More than 150 different mutations have been described in the TTR gene,…”
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Revisiting SEPT7 and the slippage of β-strands in the septin family by Brognara, Gabriel, Pereira, Humberto D' Muniz, Brandão-Neto, José, Araujo, Ana Paula Ulian, Garratt, Richard Charles

“…[Display omitted] •The highest resolution structure of a human septin provides unprecedented details.•A structural motif involving an anti-parallel β-bridge…”
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Molecular Recognition at Septin Interfaces: The Switches Hold the Key by Rosa, Higor Vinícius Dias, Leonardo, Diego Antonio, Brognara, Gabriel, Brandão-Neto, José, D'Muniz Pereira, Humberto, Araújo, Ana Paula Ulian, Garratt, Richard Charles

“…The assembly of a septin filament requires that homologous monomers must distinguish between one another in establishing appropriate interfaces with their…”
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Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism by Cassago, Alexandre, Ferreira, Amanda P. S, Ferreira, Igor M, Fornezari, Camila, Gomes, Emerson R. M, Greene, Kai Su, Pereira, Humberto M, Garratt, Richard C, Dias, Sandra M. G, Ambrosio, Andre L. B

“…Glutamine is an essential nutrient for cancer cell proliferation, especially in the context of citric acid cycle anaplerosis. In this manuscript we present…”
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Septin structure and filament assembly by Valadares, Napoleão Fonseca, d’ Muniz Pereira, Humberto, Ulian Araujo, Ana Paula, Garratt, Richard Charles

“…Septins are able to polymerize into long apolar filaments and have long been considered to be a component of the cytoskeleton alongside intermediate filaments…”
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The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs by Torini, Juliana Roberta, Romanello, Larissa, Batista, Fernanda Aparecida Heleno, Serrão, Vitor Hugo Balasco, Faheem, Muhammad, Zeraik, Ana Eliza, Bird, Louise, Nettleship, Joanne, Reddivari, Yamini, Owens, Ray, DeMarco, Ricardo, Borges, Júlio César, Brandão-Neto, José, Pereira, Humberto D'Muniz

“…Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite Schistosoma mansoni as a key enzyme of the purine salvage pathway…”
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Structural characterization of a pathogenicity-related superoxide dismutase codified by a probably essential gene in Xanthomonas citri subsp. citri by Cabrejos, Diego Antonio Leonardo, Alexandrino, André Vessoni, Pereira, Camila Malvessi, Mendonça, Deborah Cezar, Pereira, Humberto D'Muniz, Novo-Mansur, Maria Teresa Marques, Garratt, Richard Charles, Goto, Leandro Seiji

“…Citrus canker is a plant disease caused by the bacteria Xanthomonas citri subsp. citri that affects all domestic varieties of citrus. Some annotated genes from…”
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An atomic model for the human septin hexamer by cryo-EM by Mendonça, Deborah C., Guimarães, Samuel L., Pereira, Humberto D'Muniz, Pinto, Andressa A., de Farias, Marcelo A., de Godoy, Andre S., Araujo, Ana P.U., van Heel, Marin, Portugal, Rodrigo V., Garratt, Richard C.

“…[Display omitted] •We provide a first cryo-EM structure of a human septin oligomer as a free particle.•The NC-interface between SEPT6 and SEPT7 houses a large…”
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Evaluation of future estuarine floods in a sea level rise context by Lopes, Carina Lurdes, Sousa, Magda Catarina, Ribeiro, Américo, Pereira, Humberto, Pinheiro, João Pedro, Vaz, Leandro, Dias, João Miguel

“…Reliable predictions of future inundation extent within estuaries require a precise evaluation of future extreme sea levels and the application of accurate…”
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A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly by Marques da Silva, Rafael, Christe dos Reis Saladino, Giovanna, Antonio Leonardo, Diego, D'Muniz Pereira, Humberto, Andréa Sculaccio, Susana, Paula Ulian Araujo, Ana, Charles Garratt, Richard

“…[Display omitted] •The first crystal structure of a yeast septin heterodimer (Cdc3-Cdc10) provides important insights into their structural…”
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Correction: Structural characterization of a pathogenicity-related superoxide dismutase codified by a probably essential gene in Xanthomonas citri subsp. citri by Cabrejos, Diego Antonio Leonardo, Alexandrino, André Vessoni, Pereira, Camila Malvessi, Mendonça, Deborah Cezar, Pereira, Humberto D'Muniz, Novo-Mansur, Maria Teresa Marques, Garratt, Richard Charles, Goto, Leandro Seiji

“…[This corrects the article DOI: 10.1371/journal.pone.0209988.]…”
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Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus by Scorsato, Valéria, Lima, Tatiani B., Righetto, Germanna L., Zanchin, Nilson I. T., Brandão-Neto, José, Sandy, James, Pereira, Humberto D’Muniz, Ferrari, Állan J. R., Gozzo, Fabio C., Smetana, Juliana H. C., Aparicio, Ricardo

“…TOR signaling pathway regulator-like (TIPRL) is a regulatory protein which inhibits the catalytic subunits of Type 2A phosphatases. Several cellular contexts…”
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Engineering the catalytic activity of an Antarctic PET‐degrading enzyme by loop exchange by Blázquez‐Sánchez, Paula, Vargas, Jhon A., Furtado, Adriano A., Griñen, Aransa, Leonardo, Diego A., Sculaccio, Susana A., Pereira, Humberto D'Muniz, Sonnendecker, Christian, Zimmermann, Wolfgang, Díez, Beatriz, Garratt, Richard C., Ramírez‐Sarmiento, César A.

“…Several hydrolases have been described to degrade polyethylene terephthalate (PET) at moderate temperatures ranging from 25°C to 40°C. These mesophilic PET…”
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Structural Insights into Ciona intestinalis Septins: Complexes Suggest a Mechanism for Nucleotide-dependent Interfacial Cross-talk by Mendonça, Deborah C., Morais, Sinara T.B., Ciol, Heloísa, Pinto, Andressa P.A., Leonardo, Diego A., Pereira, Humberto D’Muniz, Valadares, Napoleão F., Portugal, Rodrigo V., Klaholz, Bruno P., Garratt, Richard C., Araujo, Ana P.U.

“…[Display omitted] •Septin complexes in Ciona intestinalis.•Cryo-EM visualization of the octamer, hexamer, and a tetrameric sub-complex.•Septin polymerization…”
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Orientational Ambiguity in Septin Coiled Coils and its Structural Basis by Leonardo, Diego A., Cavini, Italo A., Sala, Fernanda A., Mendonça, Deborah C., Rosa, Higor V.D., Kumagai, Patricia S., Crusca Jr, Edson, Valadares, Napoleão F., Marques, Ivo A., Brandão-Neto, José, Munte, Claudia E., Kalbitzer, Hans R., Soler, Nicolas, Usón, Isabel, André, Ingemar, Araujo, Ana P.U., D'Muniz Pereira, Humberto, Garratt, Richard C.

“…[Display omitted] •The first structures of septin coiled coils are described.•Two overlapping helical interfaces permit both parallel and antiparallel…”
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Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL) by Romanello, Larissa, Serrão, Vitor Hugo Balasco, Torini, Juliana Roberta, Bird, Louise E., Nettleship, Joanne E., Rada, Heather, Reddivari, Yamini, Owens, Ray J., DeMarco, Ricardo, Brandão-Neto, José, Pereira, Humberto D’Muniz

“…•Crystal Structure of Adenylosuccinate Lyase Apo form and in complex with AMP from Schistosoma mansoni..•Analysis of the dimer interface and structural…”
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