Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review

Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review

Egg yolk constitutes a relevant alternative source of antibodies. It presents some advantages over mammalian serum immunoglobulins regarding productivity, animal welfare and specificity. The main immunoglobulin present in avian blood (IgY) is transmitted to their offspring and accumulates in egg yol...

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Bibliographic Details
Published in:International immunopharmacology Vol. 73; pp. 293 - 303
Main Authors: Pereira, E.P.V., van Tilburg, M.F., Florean, E.O.P.T., Guedes, M.I.F.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-08-2019
Elsevier BV
Subjects:
Animal care
Animal welfare
Animals
Antibodies
Avidity
Bioterrorism
Birds
Diagnostic software
Diagnostic systems
Diagnostics
Egg Yolk - immunology
Food Preservation
Health
Humans
Immune system
Immunoglobulin Y
Immunoglobulins
Immunoglobulins - chemistry
Immunoglobulins - immunology
Immunoglobulins - therapeutic use
Immunotherapy
Infections - diagnosis
Infections - immunology
Mammals
Neoplasms - diagnosis
Neoplasms - immunology
Offspring
Phylogeny
Prophylaxis
Yolk
Birds
Immunoglobulin Y
Diagnostics
Immunotherapy
Prophylaxis
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Summary:Egg yolk constitutes a relevant alternative source of antibodies. It presents some advantages over mammalian serum immunoglobulins regarding productivity, animal welfare and specificity. The main immunoglobulin present in avian blood (IgY) is transmitted to their offspring and accumulates in egg yolks, which enables the non-invasive harvesting of high amounts of antibodies. Moreover, due to structural differences and phylogenetic distance, IgY is more suitable for diagnostic purposes than mammalian antibodies, since it does not react with certain components of the human immune system and displays greater avidity for mammalian conserved proteins. IgY has been extensively used in health researches, as both therapeutic and diagnostic tool. This article aims to review its applications in both human and veterinary health. •IgY-technology is a new frontier for biological products•IgY Abs is a non-invasive technology obtained from egg yolks of immunized hens.•A wide range of IgY applications has been successfully tested in both human and animal health.•IgY technology constitutes a relevant alternative for the mammalian antibodies production.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1567-5769
1878-1705
1878-1705
DOI:10.1016/j.intimp.2019.05.015