Search Results - "Pereira, Dhélio B"

Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America by Fantin, Raianna F, Coelho, Camila H, Berhe, Anne D, Magalhães, Luisa M D, Pereira, Dhélio B, Salinas, Nichole D, Tolia, Niraj H, Amaratunga, Chanaki, Suon, Seila, Sagara, Issaka, Narum, David L, Fujiwara, Ricardo T, Abejon, Claudia, Campos-Neto, Antonio, Duffy, Patrick E, Bueno, Lilian L

“…Plasmodium vivax is a major challenge for malaria control due to its wide geographic distribution, high frequency of submicroscopic infections, and ability to…”
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Caspase-8 mediates inflammation and disease in rodent malaria by Pereira, Larissa M. N., Assis, Patrícia A., de Araújo, Natalia M., Durso, Danielle F., Junqueira, Caroline, Ataíde, Marco Antônio, Pereira, Dhelio B., Lien, Egil, Fitzgerald, Katherine A., Zamboni, Dario S., Golenbock, Douglas T., Gazzinelli, Ricardo T.

“…Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we…”
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New highly antigenic linear B cell epitope peptides from PvAMA-1 as potential vaccine candidates by Fantin, Raianna F, Fraga, Vanessa G, Lopes, Camila A, de Azevedo, Isabella C, Reis-Cunha, João L, Pereira, Dhelio B, Lobo, Francisco P, de Oliveira, Marcela M, Dos Santos, Anderson C, Bartholomeu, Daniela C, Fujiwara, Ricardo T, Bueno, Lilian L

“…Peptide-based vaccines have demonstrated to be an important way to induce long-lived immune responses and, therefore, a promising strategy in the rational of…”
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Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi by Andrade, Alice O, Santos, Najara A C, Bastos, Alessandra S, Pontual, José D C, Araújo, Jéssica E, Silva, Alexia M V, Martinez, Leandro N, Lima, Alzemar A, Aguiar, Anna Caroline C, G Teles, Carolina B, Medeiros, Jansen F, Pereira, Dhelio B, Vinetz, Joseph M, Gazzinelli, Ricardo T, Araújo, Maisa S

“…Malaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world. Several biological…”
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Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria by Pereira, Larissa M. N., Assis, Patrícia A., de Araújo, Natalia M., Durso, Danielle F., Junqueira, Caroline, Ataíde, Marco Antônio, Pereira, Dhelio B., Lien, Egil, Fitzgerald, Katherine A., Zamboni, Dario S., Golenbock, Douglas T., Gazzinelli, Ricardo T.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Proteomic analysis of urine from patients with plasmodium vivax malaria unravels a unique plasmodium vivax protein that is absent from plasmodium falciparum by Fantin, Raianna F., Abeijon, Claudia, Pereira, Dhelio B., Fujiwara, Ricardo T., Bueno, Lilian L., Campos-Neto, Antonio

“…Five species of Plasmodium cause malaria in humans and two of them, P. vivax and P. falciparum, pose the greatest threat. Rapid antigen detection tests (RADT)…”
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Outbreak of Oropouche virus in frontier regions in western Amazon by Moreira, Hillquias Monteiro, Sgorlon, Gabriella, Queiroz, Jackson A S, Roca, Tarcio P, Ribeiro, Jessiane, Teixeira, Karolaine S, Passos-Silva, Ana Maísa, Araújo, Adrhyan, Gasparelo, Nadson Willian Felipe, Dos Santos, Alcione de Oliveira, Lugtenburg, Celina Aparecida Bertoni, Roque, Rosemary Aparecida, Villalobos Salcedo, Juan Miguel, Pereira, Dhelio B, Vieira, Deusilene

“…Oropouche virus (OROV) is characterized as a re-emerging arbovirus of great concern for public health, being responsible for several outbreaks of acute fever…”
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The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia by Santos, Marina L S, Coimbra, Roney S, Sousa, Tais N, Guimarães, Luiz F F, Gomes, Matheus S, Amaral, Laurence R, Pereira, Dhelio B, Fontes, Cor J F, Hawwari, Ibrahim, Franklin, Bernardo S, Carvalho, Luzia H

“…Severe thrombocytopenia can be a determinant factor in the morbidity of , the most widespread human malaria parasite. Although immune mechanisms may drive…”
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Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues by Cortopassi, Wilian A., Gunderson, Emma, Annunciato, Yasmin, Silva, Antony.E.S., dos Santos Ferreira, Amália, Garcia Teles, Carolina Bioni, Pimentel, Andre S., Ramamoorthi, Roopa, Gazarini, Marcos L, Meneghetti, Mario R., Guido, Rafael.V.C., Pereira, Dhelio B., Jacobson, Matthew P., Krettli, Antoniana U., Caroline C Aguiar, Anna

“…Malaria is among the tropical diseases that cause the most deaths in Africa. Around 500,000 malaria deaths are reported yearly among African children under the…”
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The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria by Antonelli, Lis R V, Leoratti, Fabiana M S, Costa, Pedro A C, Rocha, Bruno C, Diniz, Suelen Q, Tada, Mauro S, Pereira, Dhelio B, Teixeira-Carvalho, Andrea, Golenbock, Douglas T, Gonçalves, Ricardo, Gazzinelli, Ricardo T

“…Infection with Plasmodium vivax results in strong activation of monocytes, which are important components of both the systemic inflammatory response and…”
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A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of Plasmodium vivax Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic Plasmodium berghei Parasite by Lima, Luciana C., Marques, Rodolfo F., Gimenez, Alba Marina, Françoso, Katia S., Aliprandini, Eduardo, Camargo, Tarsila M., Aguiar, Anna Caroline C., Pereira, Dhelio B., Renia, Laurent, Amino, Rogerio, Soares, Irene S.

“…Infections with Plasmodium vivax are predominant in the Americas, representing 75% of malaria cases. Previously perceived as benign, malaria vivax is, in fact,…”
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γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis by Junqueira, Caroline, Polidoro, Rafael B., Castro, Guilherme, Absalon, Sabrina, Liang, Zhitao, Sen Santara, Sumit, Crespo, Ângela, Pereira, Dhelio B., Gazzinelli, Ricardo T., Dvorin, Jeffrey D., Lieberman, Judy

“…Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum– infected patients. Although previous…”
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Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax–infected reticulocytes by Junqueira, Caroline, Barbosa, Camila R. R., Costa, Pedro A. C., Teixeira-Carvalho, Andréa, Castro, Guilherme, Sen Santara, Sumit, Barbosa, Rafael P., Dotiwala, Farokh, Pereira, Dhelio B., Antonelli, Lis R., Lieberman, Judy, Gazzinelli, Ricardo T.

“…Plasmodium vivax causes approximately 100 million clinical malaria cases yearly 1 , 2 . The basis of protective immunity is poorly understood and thought to be…”
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The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis by Commons, Robert J, Simpson, Julie A, Thriemer, Kamala, Humphreys, Georgina S, Abreha, Tesfay, Alemu, Sisay G, Añez, Arletta, Anstey, Nicholas M, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Borghini-Fuhrer, Isabelle, Chu, Cindy S, D'Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J, Erhart, Annette, Gomes, Margarete S M, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Heidari, Aliehsan, Hwang, Jimee, Kager, Piet A, Ketema, Tsige, Khan, Wasif A, Lacerda, Marcus V G, Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M, Nosten, Francois, Pereira, Dhelio B, Phan, Giao T, Phyo, Aung P, Rowland, Mark, Saravu, Kavitha, Sibley, Carol H, Siqueira, André M, Stepniewska, Kasia, Sutanto, Inge, Taylor, Walter R J, Thwaites, Guy, Tran, Binh Q, Tran, Hien T, Valecha, Neena, Vieira, José Luiz F, Wangchuk, Sonam, William, Timothy, Woodrow, Charles J, Zuluaga-Idarraga, Lina, Guerin, Philippe J, White, Nicholas J, Price, Ric N

“…Chloroquine remains the mainstay of treatment for Plasmodium vivax malaria despite increasing reports of treatment failure. We did a systematic review and…”
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Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series by Palmer, Michael J, Deng, Xiaoyi, Watts, Shawn, Krilov, Goran, Gerasyuto, Aleksey, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, White, Karen L, Striepen, Josefine, Bath, Jade, Schindler, Kyra A, Yeo, Tomas, Shackleford, David M, Mok, Sachel, Deni, Ioanna, Lawong, Aloysus, Huang, Ann, Chen, Gong, Wang, Wen, Jayaseelan, Jaya, Katneni, Kasiram, Patil, Rahul, Saunders, Jessica, Shahi, Shatrughan P, Chittimalla, Rajesh, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Wittlin, Sergio, Tumwebaze, Patrick K, Rosenthal, Philip J, Cooper, Roland A, Aguiar, Anna Caroline Campos, Guido, Rafael V. C, Pereira, Dhelio B, Mittal, Nimisha, Winzeler, Elizabeth A, Tomchick, Diana R, Laleu, Benoît, Burrows, Jeremy N, Rathod, Pradipsinh K, Fidock, David A, Charman, Susan A, Phillips, Margaret A

“…Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate…”
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Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis by Commons, Robert J, Rajasekhar, Megha, Edler, Peta, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Chu, Cindy S, Cui, Liwang, Daher, André, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Lidia, Kartini, Llanos-Cuentas, Alejandro, Longley, Rhea J, Pereira, Dhelio B, Pasaribu, Ayodhia P, Pukrittayakamee, Sasithon, Rijal, Komal R, Sutanto, Inge, Taylor, Walter R J, Thanh, Pham V, Thriemer, Kamala, Vieira, José Luiz F, Watson, James A, Zuluaga-Idarraga, Lina M, White, Nicholas J, Guerin, Philippe J, Simpson, Julie A, Price, Ric N

“…Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal dosing regimen remains unclear. We undertook a systematic review and individual…”
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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 by de Vries, Laura E., Jansen, Patrick A. M., Barcelo, Catalina, Munro, Justin, Verhoef, Julie M. J., Pasaje, Charisse Flerida A., Rubiano, Kelly, Striepen, Josefine, Abla, Nada, Berning, Luuk, Bolscher, Judith M., Demarta-Gatsi, Claudia, Henderson, Rob W. M., Huijs, Tonnie, Koolen, Karin M. J., Tumwebaze, Patrick K., Yeo, Tomas, Aguiar, Anna C. C., Angulo-Barturen, Iñigo, Churchyard, Alisje, Baum, Jake, Fernández, Benigno Crespo, Fuchs, Aline, Gamo, Francisco-Javier, Guido, Rafael V. C., Jiménez-Diaz, María Belén, Pereira, Dhelio B., Rochford, Rosemary, Roesch, Camille, Sanz, Laura M., Trevitt, Graham, Witkowski, Benoit, Wittlin, Sergio, Cooper, Roland A., Rosenthal, Philip J., Sauerwein, Robert W., Schalkwijk, Joost, Hermkens, Pedro H. H., Bonnert, Roger V., Campo, Brice, Fidock, David A., Llinás, Manuel, Niles, Jacquin C., Kooij, Taco W. A., Dechering, Koen J.

“…Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a…”
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Active surveillance and early detection of community transmission of SARS‐CoV‐2 Mu variant (B.1.621) in the Brazilian Amazon by Oliveira, Gabriella S., Silva‐Flannery, Luciana, Silva, Juliana F., Siza, Charlene, Esteves, Roberto J., Marston, Barbara J., Morgan, Juliette, Plucinski, Mateusz, Roca, Tárcio P., Silva, Ana M. P., Pereira, Soraya S., Salcedo, Juan M. V., Pereira, Dhelio B., Naveca, Felipe G., Vieira Dall'Acqua, Deusilene S.

“…Through active surveillance and contact tracing from outpatients, we aimed to identify and characterize SARS‐CoV‐2 variants circulating in Porto…”
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The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis by Commons, Robert J, Simpson, Julie A, Thriemer, Kamala, Chu, Cindy S, Douglas, Nicholas M, Abreha, Tesfay, Alemu, Sisay G, Añez, Arletta, Anstey, Nicholas M, Aseffa, Abraham, Assefa, Ashenafi, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Borghini-Fuhrer, Isabelle, D'Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J, Erhart, Annette, Gomes, Margarete S M, Grigg, Matthew J, Hwang, Jimee, Kager, Piet A, Ketema, Tsige, Khan, Wasif A, Lacerda, Marcus V G, Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M, Pereira, Dhelio B, Phan, Giao T, Phyo, Aung P, Rowland, Mark, Saravu, Kavitha, Sibley, Carol H, Siqueira, André M, Stepniewska, Kasia, Taylor, Walter R J, Thwaites, Guy, Tran, Binh Q, Hien, Tran T, Vieira, José Luiz F, Wangchuk, Sonam, Watson, James, William, Timothy, Woodrow, Charles J, Nosten, Francois, Guerin, Philippe J, White, Nicholas J, Price, Ric N

“…Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency…”
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Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production by Costa, Pedro A. C., Leoratti, Fabiana M. S., Figueiredo, Maria M., Tada, Mauro S., Pereira, Dhelio B., Junqueira, Caroline, Soares, Irene S., Barber, Daniel L., Gazzinelli, Ricardo T., Antonelli, Lis R. V.

“…The function and regulation of the immune response triggered during malaria is complex and poorly understood, and there is a particular paucity of studies…”
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